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  1. 28321
    “…METHODS: This double-blind, placebo-controlled, phase 2a trial was done at both private and academic dermatology outpatient research clinics across the United States and Canada (n = 40). Patient eligibility criteria included age 18–75 years, physician-documented diagnosis of prurigo nodularis minimum 6 months duration of prurigo nodularis, presence of at least 10 pruritic nodules approximately 0.5–2 cm in size on at least two different anatomical locations (excluding face and scalp) and involving the extremities, and presence of normal-appearing skin between nodules; atopic dermatitis as a comorbidity was exclusionary. …”
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    Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a study
  2. 28322
    “…BACKGROUND: Canada is currently on target to reach the 2030 WHO goal of hepatitis C virus (HCV) elimination. …”
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    A11 NEXT STEPS IN MICRO-ELIMINATION: PEER POINT OF CARE HEPATITIS C TESTING IN VICTORIA, BRITISH COLUMBIA
  3. 28323
    “…CONCLUSIONS: Rapid molecular tests were associated with both high sensitivity and specificity, while rapid antigen tests were mainly associated with high specificity, according to the minimum performance requirements by WHO and Health Canada. Our rapid review was limited to English, peer-reviewed published results of commercial tests, and study risk of bias was not assessed. …”
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    Rapid antigen-based and rapid molecular tests for the detection of SARS-CoV-2: a rapid review with network meta-analysis of diagnostic test accuracy studies
  4. 28324
    “…SETTING: Specialty ambulatory clinics in central Canada. PARTICIPANTS: People with inflammatory arthritis (n=78; 77% rheumatoid arthritis), systemic autoimmune rheumatic diseases (n=84; 57% lupus), inflammatory bowel disease (n=93; 43% Crohn’s) and multiple sclerosis (n=72; 71% relapsing-remitting) (female 79.4%, white 84.7%, mean (SD) age 56.0 (14.3) years) received COVID-19 vaccinations between March 2021 and September 2022. …”
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    Immunogenicity and safety of mixed COVID-19 vaccine regimens in patients with immune-mediated inflammatory diseases: a single-centre prospective cohort study
  5. 28325
    “…The original METS study was funded by 10.13039/501100000024Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, 10.13039/501100000226Ontario Ministry of Health and Long-Term Care, 10.13039/501100003400Ontario Ministry of Research, Innovation and Science, UK National Institute of Academic Anaesthesia, 10.13039/100011417UK Clinical Research Collaboration, 10.13039/501100001136Australian and New Zealand College of Anaesthetists, and 10.13039/501100001779Monash University.…”
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    Sex-related differences in functional capacity and its implications in risk stratification before major non-cardiac surgery: a post hoc analysis of the international METS study
  6. 28326
    “…FUNDING: Fonds de recherche du Québec—Santé, Digital Research Alliance of Canada, Bill & Melinda Gates Foundation.…”
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    Potential population-level effectiveness of one-dose HPV vaccination in low-income and middle-income countries: a mathematical modelling analysis
  7. 28327
    “…DESIGN, SETTING, AND PARTICIPANTS: This cohort study used datalogs collected from children with cochlear implants during clinical visits to a tertiary pediatric hospital in Toronto, Ontario, Canada, from January 1, 2018, to November 11, 2021. …”
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    Exposure to Spoken Communication During the COVID-19 Pandemic Among Children With Cochlear Implants
  8. 28328
    por Sharmin, Sifat, Roos, Izanne, Simpson-Yap, Steve, Malpas, Charles, Sánchez, Marina M, Ozakbas, Serkan, Horakova, Dana, Havrdova, Eva K, Patti, Francesco, Alroughani, Raed, Izquierdo, Guillermo, Eichau, Sara, Boz, Cavit, Zakaria, Magd, Onofrj, Marco, Lugaresi, Alessandra, Weinstock-Guttman, Bianca, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Terzi, Murat, Amato, Maria Pia, Karabudak, Rana, Grand’Maison, Francois, Khoury, Samia J, Grammond, Pierre, Lechner-Scott, Jeannette, Buzzard, Katherine, Skibina, Olga, van der Walt, Anneke, Butzkueven, Helmut, Turkoglu, Recai, Altintas, Ayse, Maimone, Davide, Kermode, Allan, Shalaby, Nevin, Pesch, Vincent V, Butler, Ernest, Sidhom, Youssef, Gouider, Riadh, Mrabet, Saloua, Gerlach, Oliver, Soysal, Aysun, Barnett, Michael, Kuhle, Jens, Hughes, Stella, Sa, Maria J, Hodgkinson, Suzanne, Oreja-Guevara, Celia, Ampapa, Radek, Petersen, Thor, Ramo-Tello, Cristina, Spitaleri, Daniele, McCombe, Pamela, Taylor, Bruce, Prevost, Julie, Foschi, Matteo, Slee, Mark, McGuigan, Chris, Laureys, Guy, Hijfte, Liesbeth V, de Gans, Koen, Solaro, Claudio, Oh, Jiwon, Macdonell, Richard, Aguera-Morales, Eduardo, Singhal, Bhim, Gray, Orla, Garber, Justin, Wijmeersch, Bart V, Simu, Mihaela, Castillo-Triviño, Tamara, Sanchez-Menoyo, Jose L, Khurana, Dheeraj, Al-Asmi, Abdullah, Al-Harbi, Talal, Deri, Norma, Fragoso, Yara, Lalive, Patrice H, Sinnige, L G F, Shaw, Cameron, Shuey, Neil, Csepany, Tunde, Sempere, Angel P, Moore, Fraser, Decoo, Danny, Willekens, Barbara, Gobbi, Claudio, Massey, Jennifer, Hardy, Todd, Parratt, John, Kalincik, Tomas
    Publicado 2023
    “…At the country-level, patients in Oman, Tunisia, Iran and Canada had higher risks of secondary progressive multiple sclerosis relative to the other studied regions. …”
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    The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
  9. 28329
    por Bärnighausen, Till, Bloom, David E
    Publicado 2009
    “…The remaining studies evaluated programs in Japan (five studies), Canada (two), New Zealand (one) and South Africa (one). …”
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    Financial incentives for return of service in underserved areas: a systematic review
  10. 28330
    por Tardif, Jean-Claude, Ballantyne, Christie M., Barter, Philip, Dasseux, Jean-Louis, Fayad, Zahi A., Guertin, Marie-Claude, Kastelein, John J. P., Keyserling, Constance, Klepp, Heather, Koenig, Wolfgang, L'Allier, Philippe L., Lespérance, Jacques, Lüscher, Thomas F., Paolini, John F., Tawakol, Ahmed, Waters, David D., Pfeffer, M., Brown, V., Rouleau, J., Watkins, P., Wei, L.J., Gosselin, G., Chayer, C., Lanthier, S., Pelletier, G.B., Racine, N., Agarwal, H., Brilakis, E., Cannon, L., Carrié, D., Corbelli, J., Coste, P., de Winter, R., Diaz, A., Eisenberg, S., Ennis, B., Fajadet, J., Fam, N., Fortuin, D., Gessler, C., Grines, C., Guerra, D., Gum, H., Haldis, T., Heestermans, T., Herrman, J.P., Huynh, T., Kedhi, E., Koren, M., Kouz, S., Krolick, M., Kumkumian, G., Lavi, S., Li, R.J., Masud, ARZ, McAlhany, C., McGrew, F.A., O'Shaughnessy, C., Oude Ophuis, A.J.M., Parr, K., Penny, W., Pesant, Y., Post, H., Robinson, S., Rodes-Cabau, J., Roy, A., Schulman, S., Spence, F., Stouffer, G., Stys, T., Sussex, B., Tahirkheli, N., Tardif, J-C., Grégoire, J., ten Berg, J., van Boven, A.J., von Birgelen, C., Weinstein, D.
    Publicado 2014
    “…DESIGN AND SETTING: A prospective, double-blinded, randomized trial was conducted at 51 centres in the USA, the Netherlands, Canada, and France. Intravascular ultrasonography and QCA were performed to assess coronary atherosclerosis at baseline and 3 (2–5) weeks after the last study infusion. …”
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    Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial(†)
  11. 28331
    “…SETTING: A large population-based cohort identified from the provincial laboratory registry in Alberta, Canada. PARTICIPANTS: Adults aged ≥30 years who had outpatient measures of serum creatinine and albuminuria between May 1, 2002 and March 31, 2008. …”
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    Kidney function, albuminuria and life expectancy
  12. 28332
    “…BACKGROUND: Trauma is the most common cause of mortality among people between the ages of 1 and 45 years, costing Canadians 19.8 billion dollars a year (2004 data), yet half of all patients with major traumatic injuries do not receive evidence-based care, and significant regional variation in the quality of care across Canada exists. Accordingly, our goal is to lead a research project in which stakeholders themselves will adapt evidence-based trauma care knowledge tools to their own varied institutional contexts and cultures. …”
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    Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care: The WikiTrauma Interrupted Time Series Protocol
  13. 28333
    por Braithwaite, Bruce, Cheshire, Nicholas J., Greenhalgh, Roger M., Grieve, Richard, Hassan, Tajek B., Hinchliffe, Robert, Howell, Simon, Moore, Fionna, Nicholson, Anthony A., Soong, Chee V., Thompson, Matt M., Thompson, Simon G., Ulug, Pinar, Heatley, Francine, Anjum, Aisha, Kalinowska, Gosia, Sweeting, Michael J., Thompson, Simon G., Gomes, Manuel, Grieve, Richard, Powell, Janet T., Ashleigh, Ray, Gomes, Manuel, Greenhalgh, Roger M., Grieve, Richard, Hinchliffe, Robert, Sweeting, Michael, Thompson, Matt M., Thompson, Simon G., Ulug, Pinar, Roberts, Ian, Bell, Peter R. F., Cheetham, Anne, Stephany, Jenny, Warlow, Charles, Lamont, Peter, Moss, Jonathan, Tijssen, Jan, Braithwaite, Bruce, Nicholson, Anthony A., Thompson, Matthew, Ashleigh, Ray, Thompson, Luke, Cheshire, Nicholas J., Boyle, Jonathan R., Serracino-Inglott, Ferdinand, Thompson, Matt M., Hinchliffe, Robert J., Bell, Rachel, Wilson, Noel, Bown, Matt, Dennis, Martin, Davis, Meryl, Ashleigh, Ray, Howell, Simon, Wyatt, Michael G., Valenti, Domenico, Bachoo, Paul, Walker, Paul, MacSweeney, Shane, Davies, Jonathan N., Rittoo, Dynesh, Parvin, Simon D., Yusuf, Waquar, Nice, Colin, Chetter, Ian, Howard, Adam, Chong, Patrick, Bhat, Raj, McLain, David, Gordon, Andrew, Lane, Ian, Hobbs, Simon, Pillay, Woolagasen, Rowlands, Timothy, El-Tahir, Amin, Asquith, John, Cavanagh, Steve, Dubois, Luc, Forbes, Thomas L., Ashworth, Emily, Baker, Sara, Barakat, Hashem, Brady, Claire, Brown, Joanne, Bufton, Christine, Chance, Tina, Chrisopoulou, Angela, Cockell, Marie, Croucher, Andrea, Dabee, Leela, Dewhirst, Nikki, Evans, Jo, Gibson, Andy, Gorst, Siobhan, Gough, Moira, Graves, Lynne, Griffin, Michelle, Hatfield, Josie, Hogg, Florence, Howard, Susannah, Hughes, Cían, Metcalfe, David, Lapworth, Michelle, Massey, Ian, Novick, Teresa, Owen, Gareth, Parr, Noala, Pintar, David, Spencer, Sarah, Thomson, Claire, Thunder, Orla, Wallace, Tom, Ward, Sue, Wealleans, Vera, Wilson, Lesley, Woods, Janet, Zheng, Ting
    Publicado 2015
    “…METHODS AND RESULTS: This pragmatic multicentre (29 UK and 1 Canada) trial randomized 613 patients with a clinical diagnosis of ruptured aneurysm; 316 to an endovascular first strategy (if aortic morphology is suitable, open repair if not) and 297 to open repair. …”
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    Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial
  14. 28334
    “…METHODS: ICON7 was an international, phase 3, open-label, randomised trial undertaken at 263 centres in 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult women with newly diagnosed ovarian cancer that was either high-risk early-stage disease (International Federation of Gynecology and Obstetrics [FIGO] stage I–IIa, grade 3 or clear cell histology) or more advanced disease (FIGO stage IIb–IV), with an Eastern Cooperative Oncology Group performance status of 0–2, were enrolled and randomly assigned in a 1:1 ratio to standard chemotherapy (six 3-weekly cycles of intravenous carboplatin [AUC 5 or 6] and paclitaxel 175 mg/m(2) of body surface area) or the same chemotherapy regimen plus bevacizumab 7·5 mg per kg bodyweight intravenously every 3 weeks, given concurrently and continued with up to 12 further 3-weekly cycles of maintenance therapy. …”
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    Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial
  15. 28335
    “…METHODS: This study will be conducted in a mixed surgical and medical ICU at Hôtel-Dieu de Lévis, Quebec, Canada. We plan to involve all 5 intensivists and recruit at least 20 alert and oriented patients admitted to the ICU and their family members if available. …”
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    Development of a Decision Aid for Cardiopulmonary Resuscitation Involving Intensive Care Unit Patients' and Health Professionals' Participation Using User-Centered Design and a Wiki Platform for Rapid Prototyping: A Research Protocol
  16. 28336
    por Wang, Qianyi, Afshin, Ashkan, Yakoob, Mohammad Yawar, Singh, Gitanjali M., Rehm, Colin D., Khatibzadeh, Shahab, Micha, Renata, Shi, Peilin, Mozaffarian, Dariush, Mozaffarian, Dariush, Micha, Renata, Shi, Peilin, Ezzati, Majid, Fahimi, Saman, Khatibzadeh, Shahab, Powles, John, Elmadfa, Ibrahim, Rao, Mayuree, Wirojratana, Pattra, Lim, Stephen S., Engell, Rebecca E., Andrews, Kathryn G., Abbott, Pamela A., Abdollahi, Morteza, Abeyá Gilardon, Enrique O., Ahsan, Habibul, Al Nsour, Mohannad Abed Alfattah, Al‐Hooti, Suad N., Arambepola, Carukshi, Barennes, Hubert, Barquera, Simon, Baylin, Ana, Becker, Wulf, Bjerregaard, Peter, Bourne, Lesley T., Calleja, Neville, Castetbon, Katia, Chang, Hsing‐Yi, Cowan, Melanie J., De Henauw, Stefaan, Ding, Eric L., Duante, Charmaine A., Duran, Pablo, Elmadfa, Ibrahim, Barbieri, Heléne Enghardt, Farzadfar, Farshad, Fernando, Dulitha N., Hadziomeragic, Aida Filipovic, Fisberg, Regina M., Forsyth, Simon, Garriguet, Didier, Gaspoz, Jean‐Michel, Gauci, Dorothy, Ginnela, Brahmam N. V., Guessous, Idris, Hadden, Wilbur, Hoffman, Daniel J., Houshiar‐Rad, Anahita, Huybrechts, Inge, Hwalla, Nahla C., Ibrahim, Hajah Masni, Inoue, Manami, Jackson, Maria D., Johansson, Lars, Keinan‐Boker, Lital, Kim, Cho‐il, Koksal, Eda, Lee, Hae‐Jeung, Li, Yanping, Lipoeto, Nur Indrawaty, Ma, Guansheng, Mangialavori, Guadalupe L., Matsumura, Yasuhiro, McGarvey, Stephen T., Fen, Chan Mei, Monge‐Rojas, Rafael A., Musaiger, Abdulrahman Obaid, Nagalla, Balakrishna, Naska, Androniki, Ocke, Marga C., Oltarzewski, Maciej, Orfanos, Philippos, Ovaskainen, Marja‐Leena, Pan, Wen‐Harn, Panagiotakos, Demosthenes B., Pekcan, Gulden Ayla, Petrova, Stefka, Piaseu, Noppawan, Pitsavos, Christos, Posada, Luz Gladys, Riley, Leanne M., Sánchez‐Romero, Luz Maria, Selamat, Rusidah B. T., Sharma, Sangita, Sibai, Abla Mehio, Sichieri, Rosely, Simmala, Chansimaly, Steingrimsdottir, Laufey, Swan, Gillian, Sygnowska, Elżbieta Halina, Szponar, Lucjan, Tapanainen, Heli, Templeton, Robert, Thanopoulou, Anastasia, Thorgeirsdóttir, Holmfridur, Thorsdottir, Inga, Trichopoulou, Antonia, Tsugane, Shoichiro, Turrini, Aida, Vaask, Sirje, van Oosterhout, Coline, Veerman, J Lennert, Verena, Nowak, Waskiewicz, Anna, Zaghloul, Sahar, Zajkás, Gábor
    Publicado 2016
    “…Tropical oil–consuming countries were estimated to have the highest proportional n‐6 PUFA– and SFA‐attributable CHD mortality, whereas Egypt, Pakistan, and Canada were estimated to have the highest proportional TFA‐attributable CHD mortality. …”
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    Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease
  17. 28337
    por Schlander, Michael, Holm, Søren, Nord, Erik, Richardson, Jeff, Garattini, Silvio, Kolominsky-Rabas, Peter, Marshall, Deborah, Persson, Ulf, Postma, Maarten, Simoens, Steven, de Solà Morales, Oriol, Tolley, Keith, Toumi, Mondher, Telser, Harry, Bonham, James R, Hintner, Helmut, Diem, Anja, Laimer, Martin, Hébert, Réjean, Dasgupta, Nabarun, Pierce, Carrie E., Jordan, Melissa, Bori, Barbara, Fors, Mohanad, Prazakova, Emilie, Day, Simon, Croce, Thomas J., Fransson, Jonas, Wood, Philip, Lauridsen, Anne-Grethe, Higgs, Joanne, Aleksovska, Vesna Stojmirova, Olsen, Christina, Head, Ritchie, Asero, Antonio, Papa, Vincenzo, van Kan, Christa, Favennec, Loic, Venturella, Silvana, Salvador, Michela, Krol, Alan, Nielsen, Stephanie J., Holm, Birthe B., Lewi, Daniel, Durão, Patricia, Band, Heather, West, Andrea, Hammann, Marinda J. A., Effing-Boele, Marije C., Dekker, Hanka K., Hunter, Amy, Simpson, Amy, Liu, Gumei, Needleman, Katherine, Lewis, Debra, Rao, Gayatri, Simpson, Amy, Hunter, Amy, Whitaker, Martin J., Castro, Raquel
    Publicado 2016
    “…Helmut Hintner, Anja Diem, Martin Laimer O4 Taking Integrated Care Forward: Experiences from Canada to inspire service provision for people living with rare disease in Europe Réjean Hébert O5 Listening to the patient’s voice: social media listening for safety and benefits in rare diseases Nabarun Dasgupta, Carrie E. …”
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    8th European Conference on Rare Diseases & Orphan Products (ECRD 2016): Edinburgh, UK. 26-28 May 2016
  18. 28338
    “…Participants were pregnant (≤13 weeks and 6 days' gestation) or planning pregnancy from 31 hospitals in Canada, England, Scotland, Spain, Italy, Ireland, and the USA. …”
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    Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial
  19. 28339
    “…SETTING: The study was performed at 3 adult kidney transplant and dialysis centers in Ontario, Canada. PATIENTS: A total of 82 KT candidate subjects were recruited (39 to the KT group and 43 to the dialysis group). …”
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    Determinants of Left Ventricular Characteristics Assessed by Cardiac Magnetic Resonance Imaging and Cardiovascular Biomarkers Related to Kidney Transplantation
  20. 28340
    “…Eleven trials, conducted between 2002 and 2010, were identified as eligible, with five trials being from the United States, two from Canada, and one each from Australia and New Zealand, Finland, India, and the United Kingdom. …”
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    Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis
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