Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O(2ˉ)· production in cancer cells

por Cordani, Marco, Butera, Giovanna, Dando, Ilaria, Torrens-Mas, Margalida, Butturini, Elena, Pacchiana, Raffaella, Oppici, Elisa, Cavallini, Chiara, Gasperini, Sara, Tamassia, Nicola, Nadal-Serrano, Mercedes, Coan, Michela, Rossi, Davide, Gaidano, Gianluca, Caraglia, Michele, Mariotto, Sofia, Spizzo, Riccardo, Roca, Pilar, Oliver, Jordi, Scupoli, Maria Teresa, Donadelli, Massimo
Publicado 2018

An IL13Rα2 peptide exhibits therapeutic activity against metastatic colorectal cancer

por Bartolomé, Rubén A., Jaén, Marta, Casal, J. Ignacio
Publicado 2018

Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

por Gerber, David E., Beg, M. Shaalan, Fattah, Farjana, Frankel, Arthur E., Fatunde, Oluwatomilade, Arriaga, Yull, Dowell, Jonathan E., Bisen, Ajit, Leff, Richard D., Meek, Claudia C., Putnam, William C., Kallem, Raja Reddy, Subramaniyan, Indhumathy, Dong, Ying, Bolluyt, Joyce, Sarode, Venetia, Luo, Xin, Xie, Yang, Schwartz, Brian, Boothman, David A.
Publicado 2018

Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells

por Chakraborty, Souvik, Jiang, Chang, Gau, David, Oddo, Michael, Ding, Zhijie, Vollmer, Laura, Joy, Marion, Schiemann, William, Stolz, Donna Beer, Vogt, Andreas, Ghosh, Sujoy, Roy, Partha
Publicado 2018

Statins attenuate outgrowth of breast cancer metastases

por Beckwitt, Colin H., Clark, Amanda M., Ma, Bo, Whaley, Diana, Oltvai, Zoltán N., Wells, Alan
Publicado 2018

A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours

por Maity, Amit, Mick, Rosemarie, Huang, Alexander C., George, Sangeeth M., Farwell, Michael D., Lukens, John N., Berman, Abigail T., Mitchell, Tara C., Bauml, Josh, Schuchter, Lynn M., O’Hara, Mark, Lin, Lilie L., Demichele, Angela, Christodouleas, John P., Haas, Naomi B., Patsch, Dana M., Hahn, Stephen M., Minn, Andy J., Wherry, E. John, Vonderheide, Robert H.
Publicado 2018

Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data

por Trinh, Anne, Lädrach, Claudia, Dawson, Heather E., ten Hoorn, Sanne, Kuppen, Peter J. K., Reimers, Marlies S., Koopman, Miriam, Punt, Cornelis J. A., Lugli, Alessandro, Vermeulen, Louis, Zlobec, Inti
Publicado 2018

Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis

por Qian, Jing, Tikk, Kaja, Weigl, Korbinian, Balavarca, Yesilda, Brenner, Hermann
Publicado 2018

Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

por Tibaldi, Carmelo, Camerini, Andrea, Tiseo, Marcello, Mazzoni, Francesca, Barbieri, Fausto, Vittimberga, Isabella, Brighenti, Matteo, Boni, Luca, Baldini, Editta, Gilli, Annalisa, Honeywell, Richard, Chartoire, Myriam, Peters, Godefridus J., Giovannetti, Elisa
Publicado 2018

Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival

por Losada, Alejandro, Muñoz-Alonso, María José, Martínez-Díez, Marta, Gago, Federico, Domínguez, Juan Manuel, Martínez-Leal, Juan Fernando, Galmarini, Carlos M.
Publicado 2018

North American population-based validation of the National Comprehensive Cancer Network Practice Guideline Recommendations for locoregional lymph node and bone imaging in prostate...

por Preisser, Felix, Mazzone, Elio, Nazzani, Sebastiano, Marchioni, Michele, Bandini, Marco, Tian, Zhe, Saad, Fred, Soulières, Denis, Shariat, Shahrokh F., Montorsi, Francesco, Huland, Hartwig, Graefen, Markus, Tilki, Derya, Karakiewicz, Pierre I.
Publicado 2018

Efficacy of nivolumab in pre-treated non-small-cell lung cancer patients harbouring KRAS mutations

por Passiglia, Francesco, Cappuzzo, Federico, Alabiso, Oscar, Bettini, Anna Cecilia, Bidoli, Paolo, Chiari, Rita, Defferrari, Carlotta, Delmonte, Angelo, Finocchiaro, Giovanna, Francini, Guido, Gelsomino, Francesco, Giannarelli, Diana, Giordano, Monica, Illiano, Alfonso, Livi, Lorenzo, Martelli, Olga, Natoli, Clara, Puppo, Gianfranco, Ricevuto, Enrico, Roca, Elisa, Turci, Daniele, Galetta, Domenico
Publicado 2018

Pharmacogenetic clinical randomised phase II trial to evaluate the efficacy and safety of FOLFIRI with high-dose irinotecan (HD-FOLFIRI) in metastatic colorectal cancer patients ac...

por Páez, David, Tobeña, María, Fernández-Plana, Julen, Sebio, Ana, Virgili, Anna C., Cirera, Lluís, Barnadas, Agustí, Riera, Pau, Sullivan, Ivana, Salazar, Juliana
Publicado 2018

Long-term risk of screen-detected and interval breast cancer after false-positive results at mammography screening: joint analysis of three national cohorts

por Román, Marta, Hofvind, Solveig, von Euler-Chelpin, My, Castells, Xavier
Publicado 2018

Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma

por Mazzaferro, Vincenzo, El-Rayes, Bassel F., Droz dit Busset, Michele, Cotsoglou, Christian, Harris, William P., Damjanov, Nevena, Masi, Gianluca, Rimassa, Lorenza, Personeni, Nicola, Braiteh, Fadi, Zagonel, Vittorina, Papadopoulos, Kyriakos P., Hall, Terence, Wang, Yunxia, Schwartz, Brian, Kazakin, Julia, Bhoori, Sherrie, de Braud, Filippo, Shaib, Walid L.
Publicado 2018

Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer

por Lee, Chee Khoon, Scott, Clare, Lindeman, Geoffrey J., Hamilton, Anne, Lieschke, Elizabeth, Gibbs, Emma, Asher, Rebecca, Badger, Heath, Paterson, Robin, Macnab, Lauren, Kwan, Edmond Michael, Francis, Prudence A., Boyle, Frances, Friedlander, Michael
Publicado 2019

Prognostic impact of CD8 and programmed death-ligand 1 expression in patients with resectable non-small cell lung cancer

por Kim, Seok-Hyun, Go, Se-Il, Song, Dae Hyun, Park, Sung Woo, Kim, Hye Ree, Jang, Inseok, Kim, Jong Duk, Lee, Jong Sil, Lee, Gyeong-Won
Publicado 2019

Synergistic antitumour activity of HDAC inhibitor SAHA and EGFR inhibitor gefitinib in head and neck cancer: a key role for ΔNp63α

por Citro, Simona, Bellini, Alice, Miccolo, Claudia, Ghiani, Lavinia, Carey, Thomas E., Chiocca, Susanna
Publicado 2019

MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial

por Maille, Elodie, Brosseau, Solenn, Hanoux, Vincent, Creveuil, Christian, Danel, Claire, Bergot, Emmanuel, Scherpereel, Arnaud, Mazières, Julien, Margery, Jacques, Greillier, Laurent, Audigier-Valette, Clarisse, Moro-Sibilot, Denis, Molinier, Olivier, Corre, Romain, Monnet, Isabelle, Gounant, Valérie, Langlais, Alexandra, Morin, Franck, Levallet, Guénaëlle, Zalcman, Gérard
Publicado 2019

Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study

por Perkins, Geraldine, Svrcek, Magali, Bouchet-Doumenq, Cecile, Voron, Thibault, Colussi, Orianne, Debove, Clotilde, Merabtene, Fatiha, Dumont, Sylvie, Sauvanet, Alain, Hammel, Pascal, Cros, Jerome, André, Thierry, Bachet, Jean-Baptiste, Bardier, Armelle, Douard, Richard, Meatchi, Tchao, Peschaud, Frederique, Emile, Jean-Francois, Cojean-Zelek, Isabelle, Laurent-Puig, Pierre, Taieb, Julien
Publicado 2019