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1981por UMENE, KIYOKO, BANNO, KOUJI, KISU, IORI, YANOKURA, MEGUMI, NOGAMI, YUYA, TSUJI, KOSUKE, MASUDA, KENTA, UEKI, ARISA, KOBAYASHI, YUSUKE, YAMAGAMI, WATARU, TOMINAGA, EIICHIRO, SUSUMU, NOBUYUKI, AOKI, DAISUKE“…In this study, we review the background and early clinical evidence for these agents as new therapeutic candidates for endometrial cancer.…”
Publicado 2013
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1982“…Besides, sanguinarine was identified as a potential therapeutic drug candidate capable of targeting osteoporosis. CONCLUSION: Although candidate agents identified by our approach may be premature for clinical trials, it is clearly a direction that warrants additional consideration.…”
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1983por Turyagyenda, Laban F., Kizito, Elizabeth B., Ferguson, Morag, Baguma, Yona, Agaba, Morris, Harvey, Jagger J. W., Osiru, David S. O.“…This study was carried out to identify candidate drought-tolerance genes and expression-based markers of drought stress in cassava. …”
Publicado 2013
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1984por Yu, Xiaoqing, Bai, Guihua, Liu, Shuwei, Luo, Na, Wang, Ying, Richmond, Douglas S., Pijut, Paula M., Jackson, Scott A., Yu, Jianming, Jiang, Yiwei“…Plant drought tolerance is a complex trait that is controlled by multiple genes. Candidate gene association mapping provides a powerful tool for dissection of complex traits. …”
Publicado 2013
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1985“…For this reason, our purpose was to develop a multiplex assay that allows the genotyping of candidate single nucleotide polymorphisms (SNPs) in innate immune genes. …”
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1986Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites“…Here we show that a Pumilio/FBF (Puf) family RNA-binding protein, PfPuf2, is required for the translation repression of a number of transcripts in gametocytes including two genes encoding the transmission-blocking vaccine candidates Pfs25 and Pfs28. Whereas studies to date support a paradigm of Puf-mediated translation regulation through 3′ untranslated regions (UTRs) of target mRNAs, this study, for the first time, identifies a functional Puf-binding element (PBE) in the 5′UTR of pfs25. …”
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1987
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1988“…The candidate gene approach has been a pioneer in the field of genetic epidemiology, identifying risk alleles and their association with clinical traits. …”
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1989“…In this study, the expected number of candidate single-nucleotide variants (SNVs) in exome data for autosomal dominant or recessive Mendelian disorders was investigated under the assumption of “no genetic heterogeneity.” …”
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1990por Li, Yongqiang, Qin, Yaoguo, Yang, Na, Sun, Yufeng, Yang, Xinling, Sun, Ranfeng, Wang, Qingmin, Ling, YunEnlace del recurso
Publicado 2013
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1991
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1992
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1993“…In this sense, the most pleiotropic candidate genes were CG34460, Lsd-2 and Spn. Our analyses also revealed extensive genetic variation for all the characters mostly indicated by strong GEIs. …”
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1994por Hall, Alison M, Poole, Lee AL, Renton, Bryan, Wozniak, Alexa, Fisher, Michael, Neal, Timothy, Halloran, Christopher M, Cox, Trevor, Hampshire, Peter A“…INTRODUCTION: Patients with severe acute pancreatitis are at risk of candidal infections carrying the potential risk of an increase in mortality. …”
Publicado 2013
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1995por Bream, Elise N.A., Leppellere, Cara R., Cooper, Margaret E., Dagle, John M., Merrill, David C., Christensen, Kaare, Simhan, Hyagriv N., Fong, Chin-To, Hallman, Mikko, Muglia, Louis J., Marazita, Mary L., Murray, Jeffrey C.“…BACKGROUND: To identify genetic variants contributing to preterm birth using a linkage candidate gene approach. METHODS: We studied 99 single nucleotide polymorphisms for 33 genes in 257 families with preterm births segregating. …”
Publicado 2012
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1996por Tarigo, Jaime L., Scholl, Elizabeth H., Bird, David McK., Brown, Corrie C., Cohn, Leah A., Dean, Gregg A., Levy, Michael G., Doolan, Denise L., Trieu, Angela, Nordone, Shila K., Felgner, Philip L., Vigil, Adam, Birkenheuer, Adam J.“…In particular, alignments with the bovine parasite Theileria parva revealed that a C. felis gene, cf76, is syntenic to p67 (the leading vaccine candidate for bovine theileriosis), despite a lack of significant sequence similarity. …”
Publicado 2013
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1997
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1998por Peak, Ian R., Srikhanta, Yogitha N., Weynants, Vincent E., Feron, Christiane, Poolman, Jan T., Jennings, Michael P.“…The protein is surface exposed and its expression in a wide range of meningococcal strains suggests it is a promising vaccine candidate. In addition, immunization of mice with outer membrane vesicles of strains that overexpress NhhA in conjunction with one of TbpA, Omp85 or NspA results in synergistic bactericidal responses. …”
Publicado 2013
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1999Assessing the Validity of Asthma Associations for Eight Candidate Genes and Age at Diagnosis Effectspor Pino-Yanes, María, Corrales, Almudena, Cumplido, José, Poza, Paloma, Sánchez-Machín, Inmaculada, Sánchez-Palacios, Anselmo, Figueroa, Javier, Acosta-Fernández, Orlando, Buset, Nisa, García-Robaina, José Carlos, Hernández, Mariano, Villar, Jesús, Carrillo, Teresa, Flores, Carlos“…BACKGROUND: Before the advent of genome-wide association studies (GWAS), ADAM33, ADRB2, CD14, MS4A2 (alias FCER1B), IL13, IL4, IL4R, and TNF constituted the most replicated non-HLA candidate genes with asthma and related traits. However, except for the IL13-IL4 region, none of these genes have been found in close proximity of genome-wide significant hits among GWAS for asthma or related traits. …”
Publicado 2013
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2000por Keyvani, Hossein, Bokharaei-Salim, Farah, Monavari, Seyed Hamidreza, Esghaei, Maryam, Nassiri Toosi, Mohssen, Fakhim, Shahin, Sadigh, Zohreh Azita, Alavian, Seyed Moayed“…CONCLUSIONS: This study found that 8.9 % of the Iranian candidates for liver transplant with cryptogenic cirrhosis had occult HCV infection. …”
Publicado 2013
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