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2041por Olley, Ryan, Xavier, Guilherme M., Seppala, Maisa, Volponi, Ana A., Geoghegan, Fin, Sharpe, Paul T., Cobourne, Martyn T.“…Here, we have investigated expression of three candidate regulators for human successional tooth formation; the Fibroblast Growth Factor-antagonist SPROUTY2, the Hedgehog co-receptor GAS1 and the RUNT-related transcription factor RUNX2. …”
Publicado 2014
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2042“…We also present a list of candidate sites that show high probability of having undergone a classic sweep in the modern human lineage since the split from Neanderthals and Denisovans.…”
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2043por Moreno, Miguel Angel, Alonso, Ana, Alcolea, Pedro Jose, Abramov, Ariel, de Lacoba, Mario García, Abendroth, Jan, Zhang, Sunny, Edwards, Thomas, Lorimer, Don, Myler, Peter John, Larraga, Vicente“…All the data obtained support that LiTAT is a good target candidate for the development of new anti-leishmanial drugs.…”
Publicado 2014
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2044por Venkatesan, Aravind, Tripathi, Sushil, Sanz de Galdeano, Alejandro, Blondé, Ward, Lægreid, Astrid, Mironov, Vladimir, Kuiper, Martin“…We show how a combination of specific query definitions and additional selection criteria derived from gene expression data and prior knowledge concerning candidate proteins can be used to retrieve a set of proteins that constitute valid candidates for regulatory network extensions. …”
Publicado 2014
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2045por Salvat, Regina S., Parker, Andrew S., Choi, Yoonjoo, Bailey-Kellogg, Chris, Griswold, Karl E.“…These results represent the first systematic and rigorous assessment of the functional penalty that must be paid for pursuing progressively more deimmunized biotherapeutic candidates. Given this capacity to rapidly assess and design for tradeoffs between protein immunogenicity and functionality, these algorithms may prove useful in augmenting, accelerating, and de-risking experimental deimmunization efforts.…”
Publicado 2015
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2046
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2047“…Next-generation sequencing is an efficient and high-throughput technique that allows the identification of candidate genes involved in secondary metabolism. PRINCIPAL FINDINGS: To identify the components involved in CPP biosynthesis, a transcriptome library, prepared using root and other tissues, was assembled with the help of Illumina sequencing. …”
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2048
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2049“…Validation by western blot showed increased levels of Alpha-actinin-1 and Moesin in the UUO 1-week group, indicating that they may serve as candidate biomarkers of renal tubular injury, and significantly increased levels of Vimentin, Annexin A1 and Clusterin in the UUO 3-week group, indicating that they may serve as candidate biomarkers of interstitial fibrosis.…”
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2050
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2051por Thervet, EricEnlace del recurso
Publicado 2012
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2052
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2053
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2054por Pangilinan, Faith, Molloy, Anne M, Mills, James L, Troendle, James F, Parle-McDermott, Anne, Kay, Denise M, Browne, Marilyn L, McGrath, Emily C, Abaan, Hatice Ozel, Sutton, Marie, Kirke, Peadar N, Caggana, Michele, Shane, Barry, Scott, John M, Brody, Lawrence C“…Low maternal folate is the strongest known contributing factor, making variants in genes in the folate metabolic pathway attractive candidates for NTD risk. Multiple studies have identified nominally significant allelic associations with NTDs. …”
Publicado 2014
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2055por Monterrubio-López, Gloria P., González-Y-Merchand, Jorge A., Ribas-Aparicio, Rosa María“…Finally, we selected six novel vaccine candidates, EsxL, PE26, PPE65, PE_PGRS49, PBP1, and Erp, from M. tuberculosis that can be used to improve or design new TB vaccines.…”
Publicado 2015
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2056“…RESULTS: We validated 295 SNPs in the 90 candidate genes surveyed for association with glycogen content, 86 of were ultimately genotyped in all 144 experimental individuals from Jiaonan (JN). …”
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2057por Valverde, Guido, Zhou, Hang, Lippold, Sebastian, de Filippo, Cesare, Tang, Kun, López Herráez, David, Li, Jing, Stoneking, Mark“…We resequenced ~1.5 Mb surrounding the candidate region and identified strong signals of positive selection in the highland populations. …”
Publicado 2015
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2058“…Among the described compounds, several seem to be promising drug candidates, while others may serve as a valuable inspiration in the search for new effective therapies for AD.…”
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2059
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2060por Arbore, Roberto, Sekii, Kiyono, Beisel, Christian, Ladurner, Peter, Berezikov, Eugene, Schärer, Lukas“…To overcome the limitation of sparse functional annotation, we have performed a positional RNA-Seq analysis on different body fragments in order to identify organ-specific candidate transcripts. We then performed gene expression (in situ hybridization) and gene function (RNAi) analyses on 23 candidate transcripts, both to evaluate the predictive potential of this approach and to obtain preliminary functional characterizations of these candidate genes. …”
Publicado 2015
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