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  1. 2141
  2. 2142
    “…BACKGROUND & OBJECTIVES: Search for candidate genes for alcohol dependence (AD) has been inconsistent and inconclusive. …”
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  3. 2143
    por Newman, David J., Cragg, Gordon M.
    Publicado 2017
    “…We also added small discussion sections on candidates that are still at the preclinical stage, including a derivative of diazonamide that has an unusual interaction with tubulin (DZ-23840), which may also be a potential warhead in the future.…”
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  4. 2144
    “…MOTIVATION: We have developed geneAttribution, an R package that assigns candidate causal gene(s) to a risk variant identified by a genetic association study such as a GWAS. …”
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  5. 2145
    “…Differentially expressed genes (DEGs) were sorted and candidate genes and pathways enrichment were analyzed. …”
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  6. 2146
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  8. 2148
    “…Homologs of this gene contribute to pigmentation in other insects, and results thus represent a strong candidate for investigating the genetic basis of pigment variation in B. bifarius and other bumble bee mimicry complexes.…”
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  9. 2149
  10. 2150
    “…Our results suggest that the Cryptosporidium lipid kinase PI(4)K (phosphatidylinositol-4-OH kinase) is a target for pyrazolopyridines and that KDU731 warrants further preclinical evaluation as a drug candidate for the treatment of cryptosporidiosis. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature22337) contains supplementary material, which is available to authorized users.…”
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  11. 2151
  12. 2152
    “…Recent studies have proposed menahydroquinone-4 1,4-bis-N,N-dimethylglycinate hydrochloride (MKH-DMG), a prodrug of menahydroquinone-4 (MKH), as a promising candidate for HCC treatment including the inhibition of recurrence; MKH-DMG has been shown to achieve good selective accumulation of MKH in tumor cells, resulting in satisfactory inhibition of cell proliferation in des-γ-carboxyl prothrombin (DCP)-positive and DCP-negative HCC cell lines. …”
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  13. 2153
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  16. 2156
    “…BACKGROUND: The Candidate Phyla Radiation (CPR) is a recently described expansion of the tree of life that represents more than 15% of all bacterial diversity and potentially contains over 70 different phyla. …”
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  17. 2157
    por Zhang, Kefeng, Gao, Jianwen, Ni, Yong
    Publicado 2017
    “…In addition, copy number alterations of these DEGs, including ATAD2, CDK4, ARHGAP9 and HLA-DOA, may also contribute to OS progression. These DEGs may be candidate targets for the diagnosis and treatment of this disease.…”
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  18. 2158
    “…It also added novel candidate T6SS effectors and useful detailed information about the T6SS in R. solanacearum.…”
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  19. 2159
    “…The low-frequency variants association study was used and highlighted several strong candidate genes MUC4, MUC6, COL4A4, MYO7A, AKAP12, COL11A1, DSPP, ESPN, GPR98, PCDH15, BSN, CACNA1D, TPRN, and USH1C for microtia (P = 2.51 × 10(−4)). …”
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