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2501por Fang, Jiansong, Zhang, Pengyue, Wang, Quan, Chiang, Chien-Wei, Zhou, Yadi, Hou, Yuan, Xu, Jielin, Chen, Rui, Zhang, Bin, Lewis, Stephen J., Leverenz, James B., Pieper, Andrew A., Li, Bingshan, Li, Lang, Cummings, Jeffrey, Cheng, FeixiongEnlace del recurso
Publicado 2022
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2502por Shu, Yang, He, Lingling, Gao, Meixin, Xiao, Fan, Yang, Junru, Wang, Shiwei, Wei, Herui, Zhang, Fuyang, Wei, HongshanEnlace del recurso
Publicado 2022
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2503“…The loss of the ability of the virus to mutate and cause disease, the fact that those who become immunized by having the disease in the society reach a critical rate and create social immunity (herd immunity), and the provision of social immunity with effective vaccination can be counted as some of these situations.Candidate vaccines in the clinical phase among RNA-based vaccines: This review aimed to examine COVID-19 vaccine candidates using RNA technology and compile its current data. …”
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2504por Prendergast, Andrew, Ziganshin, Bulat A., Papanikolaou, Dimitra, Zafar, Mohammad A., Nicoli, Stefania, Mukherjee, Sandip, Elefteriades, John A.“…Visualized abnormalities included hemorrhage (peri-aortic and cranial), cardiomegaly, reduced diameter of the aorta and intersegmental vessels, lower aortic cell counts, and scoliosis (often extremely severe). (4) Conclusion: This pilot study suggests that candidate genes arising in clinical practice may be rapidly assessed via zebrafish mutants—thus permitting evidence-based decisions about pathogenicity. …”
Publicado 2022
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2505“…Genes that are part of integrated regulatory networks may represent candidate targets for MM treatment.…”
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2506
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2507“…To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. …”
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2508
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2509por Antona, Annamaria, Varalda, Marco, Roy, Konkonika, Favero, Francesco, Mazzucco, Eleonora, Zuccalà, Miriam, Leo, Giovanni, Soggia, Giulia, Bettio, Valentina, Tosi, Martina, Gaggianesi, Miriam, Riva, Beatrice, Reano, Simone, Genazzani, Armando, Manfredi, Marcello, Stassi, Giorgio, Corà, Davide, D’Alfonso, Sandra, Capello, DanielaEnlace del recurso
Publicado 2022
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2510por Abd-Rahman, Azrin N., Zaloumis, Sophie, McCarthy, James S., Simpson, Julie A., Commons, Robert J.“…New antimalarial compounds were evaluated as monotherapy (28 studies, 14 drug candidates) and combination therapy (9 studies, 10 candidates). …”
Publicado 2022
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2511por Ragotte, Robert J., Pulido, David, Lias, Amelia M., Quinkert, Doris, Alanine, Daniel G. W., Jamwal, Abhishek, Davies, Hannah, Nacer, Adéla, Lowe, Edward D., Grime, Geoffrey W., Illingworth, Joseph J., Donat, Robert F., Garman, Elspeth F., Bowyer, Paul W., Higgins, Matthew K., Draper, Simon J.“…The leading blood-stage malaria vaccine candidate, CyRPA, is essential for invasion of Plasmodium falciparum into human erythrocytes. …”
Publicado 2022
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2512por Rabea, Sameh, Yassin, Aymen S., Mohammed, Aly Fahmy, Salem-Bekhit, Mounir M., Alanazi, Fars K., Esmail, Eman Amin, Moneib, Nayera A., Hashem, Abd Elgawad M.“…CONCLUSIONS: The bacterial ghosts of Salmonella enterica serovar Typhimurium that prepared by Tween 80 Protocol showed an effective vaccine candidate that protected animals, eliminated the virulence in feces and liver. …”
Publicado 2022
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2514por Méar, Loren, Com, Emmanuelle, Fathallah, Khadija, Guillot, Laetitia, Lavigne, Régis, Guével, Blandine, Fauconnier, Arnaud, Vialard, François, Pineau, Charles“…Here, we aimed to compare the eutopic endometrium from women with or without endometriosis to identify proteins that may be considered as potential biomarker candidates. Eutopic endometrium was collected from patients with endometriosis (n = 4) and women without endometriosis (n = 5) during a laparoscopy surgery during the mid-secretory phase of their menstrual cycle. …”
Publicado 2022
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2515“…Cryo-electron microscopy became crucial in providing three-dimensional (3D) structures and creating candidates eliciting T and B cell-mediated immunity. …”
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2516por Gomez-Muñoz, Laia, Perna-Barrull, David, Caroz-Armayones, Josep M., Murillo, Marta, Rodriguez-Fernandez, Silvia, Valls, Aina, Vazquez, Federico, Perez, Jacobo, Corripio, Raquel, Castaño, Luis, Bel, Joan, Vives-Pi, Marta“…Although our preliminary study needs further validation, these candidate biomarkers could be useful for the immunological characterization of the PR phase, the stratification of patients with better disease prognosis, and a more personalized therapeutic management.…”
Publicado 2022
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2517“…PURPOSE: This study aimed to identify candidate gene markers that may facilitate chronic obstructive pulmonary disease (COPD) diagnosis and treatment. …”
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2518Organ-specific or personalized treatment for COVID-19: rationale, evidence, and potential candidates“…Besides, some FDA-approved drugs were proposed as the potential therapeutic candidates for each infected cell line. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10142-022-00841-z.…”
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2519“…While the question of mandating COVID-19 vaccine for adult transplant candidates has garnered attention in the lay and academic press, these discussions have not explicitly addressed children who may be otherwise eligible for kidney transplants. …”
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2520por Avorio, Federica, Sparacia, Gianvincenzo, Russelli, Giovanna, Seidita, Aurelio, Mamone, Giuseppe, Alduino, Rossella, Tuzzolino, Fabio, Gruttadauria, Salvatore, Miraglia, Roberto, Bulati, Matteo, Lo Re, Vincenzina“…This would encourage a more appropriate multicenter prospective study that will definitely confirm if a neurological screening in old age liver transplant candidates is appropriate.…”
Publicado 2022
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