Mostrando 701 - 720 Resultados de 135,033 Para Buscar '"Candide"', tiempo de consulta: 0.46s Limitar resultados
  1. 701
    por Hefti, Franz F
    Publicado 2008
    “…The path from lead to clinical drug candidate represents the most idiosyncratic segment of drug discovery and development. …”
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  2. 702
  3. 703
  4. 704
    “…Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. …”
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  5. 705
  6. 706
    “…METHODS: A dataset of immunohistochemistry stains in 411 patients was mined to identify potential markers of response. TLE3 emerged as a candidate marker for T response. To test the association with T sensitivity, an independent 'triple-negative' (TN) validation cohort was stained with anti-TLE3 antibody. …”
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  7. 707
    “…To help selecting appropriate candidate genes from QTLs associated with type 2 diabetes models in rat, we have developed a web tool called Candidate Gene Capture (CGC), specifically adopted for this disorder. …”
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  8. 708
  9. 709
  10. 710
    “…Based on our results, we propose the sequences “-(G/A)-G-(A/T)-(A/T)-A-T-T-T-” as HMGA1a-binding candidate sequences. Furthermore, these candidate sequences bound native human HMGA1a from SK-N-SH cells. …”
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  11. 711
    “…A total of 10 and 23 candidate QTL regions for plant persistency were identified in the 272 × WF1680 and the HR × R130 mapping populations, respectively. …”
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  12. 712
    “…CONCLUSIONS: In this report we evaluate sarcospan as a candidate gene for CFEOM1. We have found that it is highly unlikely that sarcospan is involved in the pathogenesis of this disease. …”
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  13. 713
  14. 714
    “…The cysteine protease inhibitor cystatin C has recently gained interest as a candidate diagnostic biomarker for ALS, but further studies are required to fully characterize its biomarker utility. …”
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  15. 715
  16. 716
  17. 717
  18. 718
  19. 719
    “…METHODOLOGY: We searched the literature and the animal health marketed products and pipeline for potential drug development candidates. Recently registered veterinary products offer advantages in that they have undergone extensive and rigorous animal testing, thus reducing the risk, cost and time to approval for human trials. …”
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  20. 720
    “…We identified potential candidates through protein-protein interaction predictions made using various protein interaction resources. …”
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