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701por Hefti, Franz F“…The path from lead to clinical drug candidate represents the most idiosyncratic segment of drug discovery and development. …”
Publicado 2008
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702
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703
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704“…Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. …”
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705por Ma, Yueyun, Qi, Xiaofei, Du, Jianjun, Song, Shaojun, Feng, Dongyun, Qi, Jia, Zhu, Zhidong, Zhang, Xin, Xiao, Huasheng, Han, Zeguang, Hao, XiaokeEnlace del recurso
Publicado 2009
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706por Kulkarni, Swati A, Hicks, David G, Watroba, Nancy L, Murekeyisoni, Christine, Hwang, Helena, Khoury, Thaer, Beck, Rodney A, Ring, Brian Z, Estopinal, Noel C, Schreeder, Marshall T, Seitz, Robert S, Ross, Douglas T“…METHODS: A dataset of immunohistochemistry stains in 411 patients was mined to identify potential markers of response. TLE3 emerged as a candidate marker for T response. To test the association with T sensitivity, an independent 'triple-negative' (TN) validation cohort was stained with anti-TLE3 antibody. …”
Publicado 2009
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707“…To help selecting appropriate candidate genes from QTLs associated with type 2 diabetes models in rat, we have developed a web tool called Candidate Gene Capture (CGC), specifically adopted for this disorder. …”
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708
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709por Leal-Bertioli, Soraya CM, José, Ana Carolina VF, Alves-Freitas, Dione MT, Moretzsohn, Márcio C, Guimarães, Patrícia M, Nielen, Stephan, Vidigal, Bruna S, Pereira, Rinaldo W, Pike, Jodie, Fávero, Alessandra P, Parniske, Martin, Varshney, Rajeev K, Bertioli, David J“…RESULTS: In this work we identified candidate genome regions that control disease resistance. …”
Publicado 2009
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710“…Based on our results, we propose the sequences “-(G/A)-G-(A/T)-(A/T)-A-T-T-T-” as HMGA1a-binding candidate sequences. Furthermore, these candidate sequences bound native human HMGA1a from SK-N-SH cells. …”
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711por Klimenko, Irina, Razgulayeva, Nadejda, Gau, Mitsuru, Okumura, Kenji, Nakaya, Akihiro, Tabata, Satoshi, Kozlov, Nicolay N., Isobe, Sachiko“…A total of 10 and 23 candidate QTL regions for plant persistency were identified in the 272 × WF1680 and the HR × R130 mapping populations, respectively. …”
Publicado 2010
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712“…CONCLUSIONS: In this report we evaluate sarcospan as a candidate gene for CFEOM1. We have found that it is highly unlikely that sarcospan is involved in the pathogenesis of this disease. …”
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713por Muscarella, Lucia A, Guarnieri, Vito, Sacco, Roberto, Curatolo, Paolo, Manzi, Barbara, Alessandrelli, Riccardo, Giana, Grazia, Militerni, Roberto, Bravaccio, Carmela, Lenti, Carlo, Saccani, Monica, Schneider, Cindy, Melmed, Raun, D'Agruma, Leonardo, Persico, Antonio MEnlace del recurso
Publicado 2010
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714“…The cysteine protease inhibitor cystatin C has recently gained interest as a candidate diagnostic biomarker for ALS, but further studies are required to fully characterize its biomarker utility. …”
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715
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716por Kaess, Bernhard M., Tomaszewski, Maciej, Braund, Peter S., Stark, Klaus, Rafelt, Suzanne, Fischer, Marcus, Hardwick, Robert, Nelson, Christopher P., Debiec, Radoslaw, Huber, Fritz, Kremer, Werner, Kalbitzer, Hans Robert, Rose, Lynda M., Chasman, Daniel I., Hopewell, Jemma, Clarke, Robert, Burton, Paul R., Tobin, Martin D., Hengstenberg, Christian, Samani, Nilesh J.“…Genotypes were 49,094 SNPs in >2,100 cardiometabolic candidate genes/loci as represented on the HumanCVD BeadChip version 2. …”
Publicado 2011
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717
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718por Pavelko, Kevin D., Girtman, Megan A., Mitsunaga, Yoshihiro, Mendez-Fernandez, Yanice V., Bell, Michael P., Hansen, Michael J., Allen, Kathleen S., Rodriguez, Moses, Pease, Larry R.“…We propose that epitope-modified TMEV is an excellent candidate for further development as a human T-cell vaccine for use in immunotherapy.…”
Publicado 2011
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719por Olliaro, Piero, Seiler, Jürg, Kuesel, Annette, Horton, John, Clark, Jeffrey N., Don, Robert, Keiser, Jennifer“…METHODOLOGY: We searched the literature and the animal health marketed products and pipeline for potential drug development candidates. Recently registered veterinary products offer advantages in that they have undergone extensive and rigorous animal testing, thus reducing the risk, cost and time to approval for human trials. …”
Publicado 2011
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720“…We identified potential candidates through protein-protein interaction predictions made using various protein interaction resources. …”
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