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761por Yonova-Doing, Ekaterina, Hysi, Pirro G., Venturini, Cristina, Williams, Katie M., Nag, Abhishek, Beatty, Stephen, Liew, S.H. Melissa, Gilbert, Clare E., Hammond, Christopher J.“…To this end we conducted an association study in 310 subjects from the TwinsUK cohort between variants in 8 candidate genes and serum lutein and retinal macular pigment optical density (MPOD) levels before and after supplementation. …”
Publicado 2013
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762por Liu, Jiyan, Jiang, Tingting, Wei, Liliang, Yang, Xiuyun, Wang, Chong, Zhang, Xing, Xu, Dandan, Chen, Zhongliang, Yang, Fuquan, Li, Ji-Cheng“…A classification model was established by Biomarker Pattern Software (BPS). Candidate protein biomarkers were purified by reverse phase-high performance liquid chromatography (RP-HPLC), identified by MALDI-TOF MS, LC-MS/MS and validated using enzyme-linked immunosorbent assay (ELISA). …”
Publicado 2013
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764“…Among them is the question of what constitutes best practice for the extraction of prioritized lists of candidate biomarkers from smaller studies that are ‘hypothesis generating’ in nature. …”
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765por Venu, R. C., Ma, Jianbing, Jia, Yulin, Liu, Guangjie, Jia, Melissa H., Nobuta, Kan, Sreerekha, M. V., Moldenhauer, Karen, McClung, Anna M., Meyers, Blake C., Wang, Guo-LiangEnlace del recurso
Publicado 2014
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766“…Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities. …”
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768por Aoude, Lauren G., Xu, Mai, Zhao, Zhen Zhen, Kovacs, Michael, Palmer, Jane M., Johansson, Peter, Symmons, Judith, Trent, Jeffrey M., Martin, Nicholas G., Montgomery, Grant W., Brown, Kevin M., Hayward, Nicholas K.“…The PALB2/BRCA2 protein interaction, as well as the increased melanoma risk observed in families harbouring BRCA2 mutations, makes PALB2 a candidate for melanoma susceptibility. In order to assess PALB2 as a melanoma predisposition gene, we sequenced the entire protein-coding sequence of PALB2 in probands from 182 melanoma families lacking pathogenic mutations in known high penetrance melanoma susceptibility genes: CDKN2A, CDK4, and BAP1. …”
Publicado 2014
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769por Pallavan, Bakthavatchalam, Ramesh, Venkatapathy, Dhanasekaran, Balamurali Pennagaram, Oza, Nirima, indu, Sudip, Govindarajan, Vasupradha“…RESULTS: A statistically significant increase in the candidal colonization was observed in diabetic patients as compared to normal individuals. …”
Publicado 2014
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770por Nounou, Mohamed IsmailEnlace del recurso
Publicado 2014
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771por Fukuda, Kazumasa, Yatera, Kazuhiro, Ogawa, Midori, Kawanami, Toshinori, Yamasaki, Kei, Noguchi, Shingo, Murphy, Robert S., Mukae, Hiroshi, Taniguchi, Hatsumi“…Two main conclusions were reached: (1) IOLA is a novel bacteria-like microorganism that, interestingly, possesses features of eukaryotic mitochondria. (2) IOLA is a novel pathogen candidate, and it may be the causative agent of human lung or airway disease. …”
Publicado 2014
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772por Weise, William J., Hermance, Meghan E., Forrester, Naomi, Adams, A. Paige, Langsjoen, Rose, Gorchakov, Rodion, Wang, Eryu, Alcorn, Maria D. H., Tsetsarkin, Konstantin, Weaver, Scott C.“…Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.…”
Publicado 2014
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773por Alves, Eduardo, Salman, Ahmed, Janse, Chris, Khan, Shahid, Hill, Adrian, Reyes-Sandoval, ArturoEnlace del recurso
Publicado 2014
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774por Wollenberg Valero, Katharina C., Pathak, Rachana, Prajapati, Indira, Bankston, Shannon, Thompson, Aprylle, Usher, Jaytriece, Isokpehi, Raphael D.“…We here used a bioinformatics genome-mining approach to predict and identify functions for suitable candidate markers for thermal adaptation in the chicken. …”
Publicado 2014
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775por Padden, Juliet, Megger, Dominik A., Bracht, Thilo, Reis, Henning, Ahrens, Maike, Kohl, Michael, Eisenacher, Martin, Schlaak, Jörg F., Canbay, Ali E., Weber, Frank, Hoffmann, Andreas-Claudius, Kuhlmann, Katja, Meyer, Helmut E., Baba, Hideo A., Sitek, Barbara“…The aim of this study was the identification of novel biomarker candidates for the diagnosis of cholangiocellular carcinoma (CCC) and its immunohistochemical differentiation from benign liver and bile duct cells. …”
Publicado 2014
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777por Tuupanen, S, Hänninen, U A, Kondelin, J, von Nandelstadh, P, Cajuso, T, Gylfe, A E, Katainen, R, Tanskanen, T, Ristolainen, H, Böhm, J, Mecklin, J-P, Järvinen, H, Renkonen-Sinisalo, L, Andersen, C L, Taipale, M, Taipale, J, Vahteristo, P, Lehti, K, Pitkänen, E, Aaltonen, L A“…CONCLUSIONS: This work reveals a variety of new recurrent candidate oncogene mutations to be further scrutinised as potential therapeutic targets.…”
Publicado 2014
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778por Neto, Osorio Abath, Tassy, Olivier, Biancalana, Valérie, Zanoteli, Edmar, Pourquié, Olivier, Laporte, Jocelyn“…We show an example of how the ranked lists can be used to help analyze high-throughput sequencing data to identify candidate genes, and highlight the best candidate genes matching genomic regions linked to myopathies without known causative genes. …”
Publicado 2014
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779por Long, Ji-Rong, Zhao, Lan-Juan, Liu, Peng-Yuan, Lu, Yan, Dvornyk, Volodymyr, Shen, Hui, Liu, Yong-Jun, Zhang, Yuan-Yuan, Xiong, Dong-Hai, Xiao, Peng, Deng, Hong-Wen“…RESULTS: We examined the patterns of LD and haplotype distribution in eight candidate genes for osteoporosis and/or obesity using 31 SNPs in 1,873 subjects. …”
Publicado 2004
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780por Romero-Saavedra, Felipe, Laverde, Diana, Wobser, Dominique, Michaux, Charlotte, Budin-Verneuil, Aurélie, Bernay, Benoit, Benachour, Abdellah, Hartke, Axel, Huebner, Johannes“…Due to their close relationship with the peptidoglycan, we chose PBP5, LysM, DdcP and PpiC to test their potential as vaccine candidates. These putative surface-exposed proteins were overexpressed in Escherichia coli and purified. …”
Publicado 2014
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