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1181“…BACKGROUND: Although most of the current disease candidate gene identification and prioritization methods depend on functional annotations, the coverage of the gene functional annotations is a limiting factor. …”
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1182por Quaye, L, Song, H, Ramus, S J, Gentry-Maharaj, A, Høgdall, E, DiCioccio, R A, McGuire, V, Wu, A H, Van Den Berg, D J, Pike, M C, Wozniak, E, Doherty, J A, Rossing, M A, Ness, R B, Moysich, K B, Høgdall, C, Blaakaer, J, Easton, D F, Ponder, B A J, Jacobs, I J, Menon, U, Whittemore, A S, Krüger-Kjaer, S, Pearce, C L, Pharoah, P D P, Gayther, S AEnlace del recurso
Publicado 2009
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1183“…Slc22a4 and another candidate, Xrcc5, have human orthologs that map to genomic regions associated with human ethanol sensitivity in genetic linkage studies. …”
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1184por Veerapathran, Anandharaman, Dakshinamoorthy, Gajalakshmi, Gnanasekar, Munirathinam, Reddy, Maryada Venkata Rami, Kalyanasundaram, Ramaswamy“…Since GSTs produced by parasites appear to be critical for the survival of parasites in the host, several studies evaluated the potential of parasite GSTs as vaccine candidates especially against schistosomiasis, fascioliasis and Seteria cervi. …”
Publicado 2009
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1186por Cummins, Scott F, Erpenbeck, Dirk, Zou, Zhihua, Claudianos, Charles, Moroz, Leonid L, Nagle, Gregg T, Degnan, Bernard M“…CONCLUSION: The novel rhodopsin G-protein coupled receptor-like gene subfamilies identified here do not have closely related identifiable orthologs in other metazoans, suggesting that they arose by a lineage-specific expansion as has been observed in chemosensory receptor families in other bilaterians. These candidate chemosensory receptors are expressed and often restricted to rhinophores and oral tentacles, lending support to the notion that water-borne chemical detection in Aplysia involves species- or lineage-specific families of chemosensory receptors.…”
Publicado 2009
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1187por Meyer, Michelle M, Ames, Tyler D, Smith, Daniel P, Weinberg, Zasha, Schwalbach, Michael S, Giovannoni, Stephen J, Breaker, Ronald R“…To identify additional candidate structured RNAs, we examined other IGRs with similar characteristics from 'Cand. …”
Publicado 2009
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1188por Cristina, Óvilo, Oliver, Angels, Noguera, José Luis, Clop, Alex, Barragán, Carmen, Varona, Luis, Rodríguez, Carmen, Toro, Miguel, Sánchez, Armand, Pérez-Enciso, Miguel, Silió, Luis“…This work was done to study the effect of two positional candidate genes on these traits: H-FABP and LEPR genes. …”
Publicado 2002
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1191“…The database contains 943 genes and genetic markers involved in mammary gland development and function, representing candidates for further functional studies. The candidate loci were drawn on a genetic map to reveal positional overlaps. …”
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1192por Capelle, Valérie, Remoué, Carine, Moreau, Laurence, Reyss, Agnès, Mahé, Aline, Massonneau, Agnès, Falque, Matthieu, Charcosset, Alain, Thévenot, Claudine, Rogowsky, Peter, Coursol, Sylvie, Prioul, Jean-Louis“…Among all the identified candidates, aquaporins and members of the Responsive to ABA gene family appeared better candidates than NCEDs and ZEPs.…”
Publicado 2010
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1195por Sun, Jingchun, Jia, Peilin, Fanous, Ayman H., van den Oord, Edwin, Chen, Xiangning, Riley, Brien P., Amdur, Richard L., Kendler, Kenneth S., Zhao, Zhongming“…METHODOLOGY/PRINCIPAL FINDINGS: We selected a list of schizophrenia candidate genes (SZGenes) using a multi-dimensional evidence-based approach. …”
Publicado 2010
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1196por Pointon, Jennifer J, Harvey, David, Karaderi, Tugce, Appleton, Louise H., Farrar, Claire, Stone, Millicent A., Sturrock, Roger D., Brown, Matthew A., Wordsworth, B. Paul“…CARD9 is a plausible candidate for AS given its central role in the innate immune response.…”
Publicado 2010
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1197por Isokpehi, Raphael D., Cohly, Hari H.P., Anyanwu, Matthew N., Rajnarayanan, Rajendram V., Tchounwou, Paul B., Udensi, Udensi K., Graham-Evans, Barbara E.“…In addition to the identified candidate nsSNPs for increased or reduced arsenic responsiveness, we observed i) a nsSNP that results in the breakage of a disulfide bond, as candidate marker for reduced arsenic responsiveness of KLK7, a secreted serine protease participate in normal shedding of the skin; and ii) 6 pairs of vicinal cysteines in KLK7 protein that could be binding sites for arsenic. …”
Publicado 2010
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1198por Wang, Guiping, Ye, Yun, Yang, Xiaoqin, Liao, Hongying, Zhao, Canguo, Liang, Shuang“…METHODOLOGY/PRINCIPAL FINDINGS: The candidate therapeutic compounds were identified in a two-step process. …”
Publicado 2011
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1199por Kelley, Rowena Y, Gresham, Cathy, Harper, Jonathan, Bridges, Susan M, Warburton, Marilyn L, Hawkins, Leigh K, Pechanova, Olga, Peethambaran, Bela, Pechan, Tibor, Luthe, Dawn S, Mylroie, J E, Ankala, Arunkanth, Ozkan, Seval, Henry, W B, Williams, W P“…RESULTS: In order to maximize the usage of different data sets in new studies, including association mapping, we have constructed a relational database with web interface integrating the results of gene expression, proteomic (both gel-based and shotgun), Quantitative Trait Loci (QTL) genetic mapping studies, and sequence data from the literature to facilitate selection of candidate genes for continued investigation. The Corn Fungal Resistance Associated Sequences Database (CFRAS-DB) (http://agbase.msstate.edu/) was created with the main goal of identifying genes important to aflatoxin resistance. …”
Publicado 2010
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1200por Sarup, Pernille, Sørensen, Jesper G., Kristensen, Torsten N., Hoffmann, Ary A., Loeschcke, Volker, Paige, Ken N., Sørensen, Peter“…Whole genome transcriptomic studies can point to potential candidate genes for organismal traits. However, the importance of potential candidates is rarely followed up through functional studies and/or by comparing results across independent studies. …”
Publicado 2011
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