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  1. 131161
    “…A clinical database of 360 samples was established, including the subjects’ demographic information, miRNA expression profiles and cellular experimental results. Two candidate miRNAs, miR-27a-3p, and miR-30b-5p, were identified by a high-throughput sequencing screen and validated by qRT–PCR assays. …”
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    MiR-27a-3p and miR-30b-5p inhibited-vitamin D receptor involved in the progression of tuberculosis
  2. 131162
    “…This study characterizes a safer LAIV candidate in two mouse models mimicking infants and severely immunocompromised patients and proposes a simple attenuation strategy that could broaden LAIV application and reduce influenza burden in high-risk populations. …”
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    Optimizing the Live Attenuated Influenza A Vaccine Backbone for High-Risk Patient Groups
  3. 131163
    “…Hence, bta-miR-148a and KLF6 are potential candidates for increased milk synthesis and the production of valuable milk components in dairy cattle through marker-assisted selection in molecular breeding. …”
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    Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells
  4. 131164
    “…Our study provides data suggesting that 17D-IRES, with its prominent advantages, could be a vaccine candidate against YF. Moreover, this IRES-based bicistronic technology platform represents a promising strategy for developing other live attenuated vaccines against emerging viruses.…”
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    Development of a Bicistronic Yellow Fever Live Attenuated Vaccine with Reduced Neurovirulence and Viscerotropism
  5. 131165
    “…New powerful antimicrobial agents against Gram-positives are needed, since antibiotics like vancomycin fail to cure vancomycin-intermediate resistant S. aureus (VISA) and vancomycin-resistant enterococci (VRE) infections. One candidate substance with promising activity against these organisms is cervimycin, which is an antibiotic complex with a yet unknown mode of action. …”
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    Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes
  6. 131166
    “…The results indicated that PeLOX4 may be a candidate gene involved in fruit ripeness and the formation of volatile aroma compounds, with the increase in fruit ripening, the expression level of PeLOX4 increased and the LOX enzyme activity increased accordingly, thereby promoting the synthesis of volatile esters in fruit pulp. …”
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    Genome-Wide Association and Expression Analysis of the Lipoxygenase Gene Family in Passiflora edulis Revealing PeLOX4 Might Be Involved in Fruit Ripeness and Ester Formation
  7. 131167
    “…The SN-38-loaded pH-sensitive lipid nanoparticles represent a promising candidate for delivering the potent drug SN-38 to tumour sites. …”
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    Novel pH-Responsive Cubosome and Hexosome Lipid Nanocarriers of SN-38 Are Prospective for Cancer Therapy
  8. 131168
    “…Bi-variable binary logistic regression for the selection of potential candidate variables at p-value < 0.25 for multivariable analysis and multivariable binary logistic regression to identify the association between homebirth preference and independent variables were carried out. …”
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    Preference of homebirth and associated factors among pregnant women in Arba Minch health and demographic surveillance site, Southern Ethiopia
  9. 131169
    “…Recently, our group showed that antibody-derived immunopeptides (encoding complementarity-determining regions, CDRs) provide attractive glaucoma medication candidates and directly interfere its pathogenic mechanisms by different modes of action. …”
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    Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1
  10. 131170
    “…CONCLUSION: Invasive right atrium pressure may act as a potential candidate for TR evaluation and procedural guidance. …”
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    Hemodynamics of transcatheter tricuspid valve replacement with Lux-Valve
  11. 131171
    “…The anti-proliferative actions of some of these oxysterols especially the cholesterol 3,5,6-triol (#5) as established on selected cancer cell lines in this study support our previous studies and make them candidates for research for human application.…”
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    Oxysterols in catfish skin secretions (Arius bilineatus, Val.) exhibit anti-cancer properties
  12. 131172
    “…Also, we have selected 24 Gallus gallus candidate reference genes from NCBI, and total RNA was isolated from the broiler, improved Aseel embryo tissues, and their expression profiles were studied by real-time quantitative PCR (qPCR). …”
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    Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens
  13. 131173
    “…The TWA strategy embedded in MOALNS-SA assigns appropriate candidate time windows to customers. The proposed MOALNS-SA produces results that are comparable with the CPLEX solver and those of the self-learning non-dominated sorting genetic algorithm-II, multi-objective ant colony algorithm, and multi-objective particle swarm optimization algorithm for 2E-EVRPTWA. …”
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    Emergency logistics network optimization with time window assignment
  14. 131174
    “…CONCLUSION: Metformin might be a candidate drug for the treatment of NAFLD which exhibits therapeutic effect on NAFLD patients associated with ALT, AST, TG, TC and IR while was not correlated with BMI. …”
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    Effect of metformin on nonalcoholic fatty liver based on meta-analysis and network pharmacology
  15. 131175
    “…CONCLUSION: We recommend that patients with metastases from their neuroendocrine tumor who develop hypoglycemia be evaluated for insulinoma and if found should be treated with diazoxide and if not surgical candidates to consider hepatic artery embolization. …”
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    ODP315 Hypoglycemia: Neuroendocrine Tumor of the Pancreas with Liver Metastasis and Transformation to Insulinoma
  16. 131176
    “…Dioscorea nipponica Makino is an optimal candidate to develop the diosgenin industry in North China. …”
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    In vitro regeneration and its histological characteristics of Dioscorea nipponica Makino
  17. 131177
    “…The role of pre-donation sociopsychological evaluation of the donor candidate is as important to the success of the procedure as is the medical assessment. …”
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    Quality of life, depression and anxiety in potential living liver donors for pediatric recipients: A retrospective single center experience
  18. 131178
    “…Others with altered gene structure are considered gene candidates. The amino acid side chains at many of the polymorphic positions in MHCY class I are directed away rather than into the antigen-binding groove as is typical of peptide-binding major histocompatibility complex class I molecules. …”
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    The Gallus gallus RJF reference genome reveals an MHCY haplotype organized in gene blocks that contain 107 loci including 45 specialized, polymorphic MHC class I loci, 41 C-type lectin-like loci, and other loci amid hundreds of transposable elements
  19. 131179
    “…Due to their potent regulatory roles in molecular pathways, microRNAs are among the novel candidates for the diagnosis and treatment of diseases like SSc. …”
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    MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosis
  20. 131180
    “…BACKGROUND: Multiple COVID-19 vaccines have now been licensed for human use, with other candidate vaccines in different stages of development. …”
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    COVID-19 vaccine acceptance and its socio-demographic and emotional determinants: A multi-country cross-sectional study
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