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  1. 131181
    “…IMPORTANCE: There is substantial controversy with regards to the adequacy and use of noncontrast head computed tomography (NCCT) for late-window acute ischemic stroke in selecting candidates for mechanical thrombectomy. OBJECTIVE: To assess clinical outcomes of patients with acute ischemic stroke presenting in the late window who underwent mechanical thrombectomy stratified by NCCT admission in comparison with selection by CT perfusion (CTP) and diffusion-weighted imaging (DWI). …”
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    Association of Noncontrast Computed Tomography and Perfusion Modalities With Outcomes in Patients Undergoing Late-Window Stroke Thrombectomy
  2. 131182
    “…In addition, further analysis of the top five pathways enriched by KEGG, nine key candidate genes (including SLC18A2, SNAP25, CACNA1B, GABRG2, DRD3, CAMK2A, NR5A1, and STAR) were identified, which could play a crucial role in the formation of semen. …”
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    Comparative Transcriptome Analysis Provided a New Insight into the Molecular Mechanisms of Epididymis Regulating Semen Volume in Drakes
  3. 131183
    “…A rumen microbial predictor consisting of an unclassified genus in the candidate division SR1 (numerator) and an unclassified genus in the order Bacteroidales (denominator) accurately distinguished the two feeding schemes. …”
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    Rumen Microbial Predictors for Short-Chain Fatty Acid Levels and the Grass-Fed Regimen in Angus Cattle
  4. 131184
    “…Next, we identified some candidate proteins via various approaches to reveal the potential mechanism among these m7G-related clusters. …”
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    A Novel m7G-Related Genes-Based Signature with Prognostic Value and Predictive Ability to Select Patients Responsive to Personalized Treatment Strategies in Bladder Cancer
  5. 131185
    “…Background: Phase 1 clinical trials represent a critical phase of drug development because new candidate therapeutic agents are tested for the first time on humans. …”
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    Trends of Phase I Clinical Trials in the Latest Ten Years across Five European Countries
  6. 131186
    “…WINNER users can use this new tool to robustly evaluate a list of candidate genes, proteins, or metabolites produced from high-throughput biology experiments, as long as there is available gene/protein/metabolic network information.…”
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    WINNER: A network biology tool for biomolecular characterization and prioritization
  7. 131187
    “…Our results have shown that in accordance with heparin and LMWH, fondaparinux can also be a candidate for “drug repurposing” in COVID-19 therapy, not only because of their anticoagulant but also possible antiviral effects.…”
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    Promising Drug Fondaparinux for the Treatment of COVID-19: an In Silico Analysis of Low Molecular Weight Heparin, Direct Oral Anticoagulant, and Antiplatelet Drug Interactions with Host Protease Furin
  8. 131188
    “…Since the eye is easily accessible to local administration, eye diseases may be excellent candidates to evaluate novel therapeutic approaches. …”
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    Insights and future directions for the application of perinatal derivatives in eye diseases: A critical review of preclinical and clinical studies
  9. 131189
    “…The present study examined the in vitro effects of allicin and alcoholic garlic extract at different concentrations as natural disinfectant candidates compared with KOH 5% as a chemical disinfectant against Eimeria tenella oocysts and the in vivo infectivity of these treated oocysts in chickens. …”
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    Comparative Effect of Allicin and Alcoholic Garlic Extract on the Morphology and Infectivity of Eimeria tenella Oocysts in Chickens
  10. 131190
    “…At the end, the results of ADMET studies confirmed these derivatives as drug like candidates. Conclusively, the current study suggested substituted oxadiazoles as the potential anticancer compounds which exhibited more selectivity towards VEGFR2 in comparison to EGFR. …”
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    Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies
  11. 131191
    “…Couples where the males were normozoospermic were placed in the control group (15 participants), while couples where males had teratozoospermia were placed in the study group (13 participants). Thirteen candidate miRNAs were selected for qPCR analysis, based on our literature search. …”
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    Association between Sperm Morphology and Altered Sperm microRNA Expression
  12. 131192
    “…We identified the putative candidate genes for QTLs namely Q.iari.dt.chl.1, Q.iari.dt.sdw.16, Q.iari.dt.sdw.9 and Q.iari.dt.tpc.1 which are potentially involved in the mechanism regulating phosphorus use efficiency through improved P absorption due to improved root architectural traits and better mobilization such as sulfotransferase involved in postembryonic root development, WALLS ARE THIN1 (WAT1), a plant-specific protein that facilitates auxin export; lectin receptor-like kinase essentially involved in plant development, stress response during germination and lateral root development and F-box component of the SKP-Cullin-F box E3 ubiquitin ligase complex and strigolactone signal perception. …”
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    Genome-wide association studies reveal putative QTLs for physiological traits under contrasting phosphorous conditions in wheat (Triticum aestivum L.)
  13. 131193
    “…This study reveals that (Y(0.2)Dy(0.2)Ho(0.2)Er(0.2)Yb(0.2))(3)Al(5)O(12) is a promising candidate for the future generation of thermal barrier materials.…”
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    A Promising High-Entropy Thermal Barrier Material with the Formula (Y(0.2)Dy(0.2)Ho(0.2)Er(0.2)Yb(0.2))(3)Al(5)O(12)
  14. 131194
    “…Blood samples were collected and sequenced by next generation sequencing and Candidate pathogenic variants were identified using Sanger sequencing in all family members. …”
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    Genotype and phenotype spectrum of 10 children with STXBP1 gene-related encephalopathy and epilepsy
  15. 131195
    “…Finally, subsequent phylogenetic and immunohistochemical analysis for the PITX2, the identified DEGs in the RNA-seq, was helpful to further elucidate the transcriptional regulatory mechanism of candidate genes. In conclusion, the current results are of considerable importance in enriching our understanding of the intrinsic relationship between the skin derivatives and lifestyles of newborn Alligator sinesis.…”
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    RNA-Sequencing Analysis of Gene-Expression Profiles in the Dorsal Gland of Alligator sinensis at Different Time Points of Embryonic and Neonatal Development
  16. 131196
    “…All of the aforementioned analyses concluded that the designed vaccine molecule as a good candidate to be used in experimental studies to disclose its immune protective efficacy in animal models.…”
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    Computational Design of a Chimeric Vaccine against Plesiomonas shigelloides Using Pan-Genome and Reverse Vaccinology
  17. 131197
    “…Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis.…”
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    In silico and in vitro analysis of microRNAs with therapeutic potential in atherosclerosis
  18. 131198
    “…Our findings suggested that FLaAN/C could be a promising candidate for MS therapy.…”
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    Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway
  19. 131199
    “…Our findings illustrated the genetic evolution characteristics of the emerging genotype and the pathogenic mechanism and antigenic diversity of different genotype strains, These findings also provided an excellent vaccine candidate strain and a suitable BVDV challenge strain for the comprehensive prevention and control of BVDV.…”
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    Isolation of BVDV-1a, 1m, and 1v strains from diarrheal calf in china and identification of its genome sequence and cattle virulence
  20. 131200
    “…Due to his age and additional medical issues, the patient was not a candidate for surgical valve replacement. We decided to try medical therapy with a fluoroquinolone antibiotic since the bacteria was susceptible to it. …”
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    ‘TAVR Infected Pseudomonas Endocarditis’: a case report
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