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  1. 131261
    “…Conclusion: SHD plays a critical role in anti-inflammation and anti-apoptosis via inhibiting the NF-κB signaling pathway and activating PI3K/AKT anti-apoptosis pathway, indicating that SHD is a candidate herbal drug for further investigation in treating cisplatin-induced AKI.…”
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    Network pharmacology, molecular docking, and experimental verification reveal the mechanism of San-Huang decoction in treating acute kidney injury
  2. 131262
    “…METHODS: In a double-blind, randomized, placebo-controlled trial, we enrolled 143 patients (82% men, 58 ± 11 years) with stable CAD and not candidates for complete CABG. They received 100 million BMC (n = 77) or placebo (n = 66) injected into ischemic non-revascularized segments during CABG. …”
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    Additional improvement in regional myocardial ischemia after intracardiac injection of bone marrow cells during CABG surgery
  3. 131263
    “…Metabolomic profiling was performed on the plasma of those patients and healthy volunteers to select candidate metabolomic biomarkers. A novel diagnostic model for AFP negative HCC was established based on Random forest analysis, and prognostic biomarkers were also identified. …”
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    Metabolomic biomarkers for the diagnosis and post-transplant outcomes of AFP negative hepatocellular carcinoma
  4. 131264
    “…Although further analyses are necessary to properly elucidate the molecular mechanisms, our results suggest that these two bacterial isolates are potential candidates as sources for bioproducts, contributing to a more sustainable agriculture.…”
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    Bacterial volatile organic compounds (VOCs) promote growth and induce metabolic changes in rice
  5. 131265
    “…RESULTS: We nominate 11 strong candidate LAM TFs shared across human and mouse networks (BHLHE41, HIF1A, ID2, JUNB, MAF, MAFB, MEF2A, MEF2C, NACA, POU2F2 and SPI1). …”
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    BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues
  6. 131266
    “…At variance, variants in putative candidate genes did not exhibit a functional effect, with the exception of a CFHR5 variant. …”
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    An ex vivo test to investigate genetic factors conferring susceptibility to atypical haemolytic uremic syndrome
  7. 131267
    “…Taken together, the present results reinforce the leishmanicidal and immunomodulatory effects of Brazilian green propolis, and demonstrate promising potential for the EPP-AF(®) propolis gel formulation as a candidate for adjuvant therapy in the treatment of Cutaneous Leishmaniasis.…”
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    Leishmanicidal and immunomodulatory properties of Brazilian green propolis extract (EPP-AF(®)) and a gel formulation in a pre-clinical model
  8. 131268
    “…In this context, the use of other therapeutic strategies such as liver transplantation in selected candidates, locoregional treatments or new chemotherapy schemes based on immunotherapy or targeted therapies may contribute in improving the overall survival of patients with CCA. …”
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    New Challenges in the Management of Cholangiocarcinoma: The Role of Liver Transplantation, Locoregional Therapies, and Systemic Therapy
  9. 131269
    “…These findings indicate that HNRNPA2B1-m6A RNA modification-derived MicroRNA-92a upregulation and section from the local CRC acts a candidate noninvasive serum biomarker in colorectal cancer. …”
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    HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer
  10. 131270
    “…ABSTRACT: Objective: Circulating tumor DNA (ctDNA) is a candidate biomarker of cancer with practice-changing potential in the detection of both early and residual disease. …”
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    Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer
  11. 131271
    “…Our study aimed to investigate abnormal exosomal miRNA patterns via microarray analysis and identify candidate biomarkers for CSVD. METHODS: We isolated exosomes from the plasma of all subjects and identified exosomes via currently universally accepted methods. …”
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    Exosomal miR-320e as a Novel Potential Biomarker for Cerebral Small Vessel Disease
  12. 131272
    “…Vitis vinifera leaf extract is an interesting potential candidate for an alternative treatment approach. Our study examined the pharmacological potential of VVLE and its effects on E. papillata oocyst sporulation by investigating its ability to inhibit the sporulation of coccidian oocysts in vitro and in mice. …”
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    The Anticoccidial Effect of Alcoholic Vitis vinifera Leaf Extracts on Eimeria papillate Oocysts Isolated in Mice In Vitro and In Vivo
  13. 131273
    “…Therefore, Diospyros villosa leaves, stem bark and nanoparticles synthesized showed high potential for being considered as a candidate for an anti-cancer regimen.…”
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    Cytotoxic Potential of Diospyros villosa Leaves and Stem Bark Extracts and Their Silver Nanoparticles
  14. 131274
    “…The optimal cutoff points for candidate risk factors for predicting eGFR(6m) <60 occurrence were determined using the Youden index. …”
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    Association of Pre- and Post-Donation Renal Function with Midterm Estimated Glomerular Filtration Rate in Living Kidney Donors: A Retrospective Study
  15. 131275
    “…Hence, those enrolling in such an exercise program should be monitored frequently for changes in BP over time for any timely intervention appropriate for the candidate. However, being a small-scale study, the result of this study would be validated by further observing the underlying causes of the increment of systolic blood pressure.…”
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    Effect of Three-Month Weight Training Program on Resting Heart Rate and Blood Pressure in Healthy Young Adult Males
  16. 131276
    “…Bivariate analysis was done and variables with a p value<0.2 were taken as a candidate for multilevel multivariable logistic regression. …”
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    Spatial distribution and determinants of newborn care within 2 days of postpartum period among women with at least one antenatal care visit in Ethiopia: Mixed effect multilevel analysis
  17. 131277
    “…Based on the alignment of flanking SNP markers to the Clementine reference genome, the candidate gene for seedlessness hovered in a ~ 6.0 Mb region between 3.97 Mb (AX-160906995) to 10.00 Mb (AX-160536283). …”
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    Construction of a high density genetic linkage map to define the locus conferring seedlessness from Mukaku Kishu mandarin
  18. 131278
    “…Thus, MAST4 variants should be considered the potential candidate gene in patients with neurodevelopmental disorders clinically marked by infantile spasms.…”
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    De novo variants in MAST4 related to neurodevelopmental disorders with developmental delay and infantile spasms: Genotype-phenotype association
  19. 131279
    “…Signals were used by programs when selecting candidates to interview. MAIN OUTCOMES AND MEASURES: The main outcome of interest was the association of signaling with interview selection. …”
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    Interview Invitations for Otolaryngology Residency Positions Across Demographic Groups Following Implementation of Preference Signaling
  20. 131280
    “…The extracellular e1 sequence of KCNJ10, the inwardly rectifying potassium channel 4.1, has been subject to fierce debate for its role as a candidate autoantigen in multiple sclerosis. Inwardly rectifying potassium channel 4.1 is expressed in the central nervous system but also in peripheral tissues, raising concerns about the central nervous system-specificity of such autoreactivity. …”
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    Aglycosylated extracellular loop of inwardly rectifying potassium channel 4.1 (KCNJ10) provides a target for autoimmune neuroinflammation
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