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  1. 131421
    “…Patients’ demographics, medical history, clinical and laboratory records on admission were extracted from the electronic medical records. Candidate predictors of AKI were screened in the group-LASSO (gLASSO) regression, and then they were incorporated into BNs analysis for further interrelationship modeling and disease prediction. …”
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    Application of group LASSO regression based Bayesian networks in risk factors exploration and disease prediction for acute kidney injury in hospitalized patients with hematologic malignancies
  2. 131422
    “…Furthermore, as these molecules can be used for in vivo imaging, they pose as attractive candidates for theranostic approaches.…”
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    Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
  3. 131423
    “…CONCLUSIONS: Our study suggested that VRTN insertion may not be a strong or the only candidate causal mutation for the QTL on SSC7 for teat number in the analyzed Duroc pig populations. …”
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    Genome-wide association analyses identify known and novel loci for teat number in Duroc pigs using single-locus and multi-locus models
  4. 131424
    “…TRIAL REGISTRATION: The study was registered at Netherlands Trial Register http://www.trialregister.nl. Candidate number: 23527, NTR number: NTR5541, NL number: NL5425 (https://www.trialregister.nl/trial/5424), Retrospectively registered: NTR: 22 December 2015.…”
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    Clinical impact of endemic NDM-producing Klebsiella pneumoniae in intensive care units of the national referral hospital in Jakarta, Indonesia
  5. 131425
    “…CONCLUSIONS: Our findings suggest that both NVP-AEW541 and GSK-J4 could be potentially repurposed as candidate drugs against T. gondii infection. [Image: see text]…”
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    Two old drugs, NVP-AEW541 and GSK-J4, repurposed against the Toxoplasma gondii RH strain
  6. 131426
    “…The difference analysis of the three groups suggested that none of the above-mentioned variables can be used as potential prognostic candidates. On the other hand, high SCC cows exhibited higher blood neutrophil to lymphocyte ratio (NLR, P < 0.01) and platelet to lymphocyte ratio (PLR, P < 0.01) than low SCC cows, with a higher NLR (P < 0.01) in middle SCC than in low SCC cows. …”
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    Prognostic potential of pre-partum blood biochemical and immune variables for postpartum mastitis risk in dairy cows
  7. 131427
    “…PMV and PMCS might therefore aid to identify patients who are poor candidates for FLR augmentation using PVE alone. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00270-020-02416-6) contains supplementary material, which is available to authorized users.…”
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    Correlation Between Sarcopenia and Growth Rate of the Future Liver Remnant After Portal Vein Embolization in Patients with Colorectal Liver Metastases
  8. 131428
    “…Our results describe the biological characteristics of five hPMSCs and provide insights to aide in the selection process of candidates for MSCs treatment. Overall, UC- and CV-MSCs appear to be ideal sources of primary MSCs for clinical treatment and future research.…”
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    Comparative separation methods and biological characteristics of human placental and umbilical cord mesenchymal stem cells in serum-free culture conditions
  9. 131429
    “…Significant SNPs mapped in introns of candidate genes (45%), in intergenic regions (36%), were 0–5 kb upstream or downstream of the closest gene (14%) or were synonymous substitutions (5%). …”
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    Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats
  10. 131430
    “…Sixteen genes responsible for bone and cartilage formation were downregulated in BCO-affected broilers being strong candidate genes to trigger this disorder.…”
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    RNA-seq reveals downregulated osteochondral genes potentially related to tibia bacterial chondronecrosis with osteomyelitis in broilers
  11. 131431
    “…The overlapping work of some of the teams involves continuing animal research whilst entering vaccine candidates into Phase I trials alongside planning their Phase II trials. …”
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    From COVID-19 research to vaccine application: why might it take 17 months not 17 years and what are the wider lessons?
  12. 131432
    “…CpG methylation sites serve as relevant biomarker candidates to monitor and diagnose LC, providing new insight into the immune mechanisms understanding the progression of HBV-related liver fibrosis and cirrhosis.…”
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    The signature of HBV-related liver disease in peripheral blood mononuclear cell DNA methylation
  13. 131433
    “…Thermus thermophilus contains an easily manipulable genome and is therefore among the best candidate microbes for a “hot” expression system. We previously identified a strong and inducible promoter that was active in T. thermophilus under supersaturated silica conditions. …”
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    Development of a new gene expression vector for Thermus thermophilus using a silica-inducible promoter
  14. 131434
    “…METHODS: The expression of miR-363 in ccRCC tissues compared with adjacent normal renal tissues was detected by quantitative real-time polymerase chain reaction, and the association between miR-363 levels and prognosis of ccRCC patients was analyzed. The candidate target gene of miR-363 was determined by in silico analysis and luciferase reporter assays. …”
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    miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1
  15. 131435
    “…Serine hydrolases (n = 30) were identified by mass spectrometry in subclinical and clinical rejection patients with 4 non-overlapping candidates between the two groups (i.e. ABHD14B, LTF, PR3/PRTN3 and PRSS12). …”
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    Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
  16. 131436
    “…Malaria vaccination could substantially reduce malaria episodes and deaths. One vaccine candidate is the whole sporozoite PfSPZ Vaccine, consisting of irradiated cryopreserved sporozoites administered by direct venous inoculation (DVI). …”
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    Caregiver and community perceptions and experiences participating in an infant malaria prevention trial of PfSPZ Vaccine administered by direct venous inoculation: a qualitative study in Siaya County, western Kenya
  17. 131437
    “…In the present study, we have produced a bivalent therapeutic vaccine candidate consisting of the human EDA (hEDA) fused to E7 proteins from HPV16 and HPV18 (hEDA-HPVE7-16/18) and evaluate its potential as a therapeutic vaccine against cervical cancer. …”
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    Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens
  18. 131438
    “…This study further helps to identify candidate pathways and targets for effective clinical intervention and may help to inform clinical trials in the future.…”
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    IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism
  19. 131439
    “…METHODS: Genome-wide methylome and RNA sequencing data from a set of ccRCC and normal tissue samples from The Cancer Genome Atlas (TCGA) database were integrated to identify candidate CpG loci involved in cancer onset. MiR-30a-5p expression and promoter methylation were quantitatively assessed by PCR in a tissue set (Cohort #1) and urine sets (Cohorts #2 and 3) from IPOPorto and Homburg University Hospital. …”
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    MicroRNA-30a-5p(me): a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples
  20. 131440
    “…We illustrate a software package, InteractionTransformer, which embeds logistic regression with advanced model building capacity by using machine learning algorithms to extract candidate interaction features from a random forest model for inclusion in the model. …”
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    Don’t dismiss logistic regression: the case for sensible extraction of interactions in the era of machine learning
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