“…This was based on a fixed-dose nanocombination of praziquantel and miltefosine, an antischistosomal repurposing candidate, co-loaded at reduced doses into lipid nanocapsules, for single dose oral therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The reference analytical performances and the relatively low cost of ICP-MS, accompanied by the advantageous cost of a single sweat chloride assay, make this technology the best candidate to provide a top reference method for the quantification of chloride in sweat. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the constructed lncRNA–miRNA–mRNA regulatory network revealed tenascin R (TNR), cystic fibrosis transmembrane conductance regulator (CFTR), ATP-binding cassette sub-family A member 12 (ABCA12), and collagen 9A2 (COL9A2) as the candidate targets of LINC00515 and RP11-388P9.2. CONCLUSIONS: In summary, we revealed the profiles of lncRNA and mRNA in OP. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transcriptomics studies reveal that candidate chemoreceptor proteins include variant Ionotropic Receptors (IRs) including both co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, additional studies as the sequencing of C. violaceum genome and the potential toxins secreted will provide useful information render it a potential candidate for the biological control strategies of malaria and other disease vectors.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study aimed to identify serum microRNA (miRNA) candidates that could differentiate between posterior circulation stroke and peripheral vertigo, among patients presenting with acute vertigo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Subsequently, bioinformatics analysis showed KSR2 as a potential candidate for SF3B1-mediated functions in endometrial cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Considering all reported factors, promising candidates to be recommended for implementation in a Nordic municipality context are ‘Senior meetings’, ‘preventive home visits’ and ‘exercise interventions’ on its own or combined with other components.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: A genome-wide association mapping was performed on a set of 253 non-glutinous rice accessions consisting of 83 indica and 170 japonica cultivated rice varieties through phenotyping for 11 ECQ traits in two consecutive years and genotyping with 210 polymorphic SSR and candidate-gene markers. These markers amplified 747 alleles with an average of 3.57 alleles per locus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This might explain the high prevalence of certain disorders; however, genomic data provide no evidence for fixed coding variants that explain these predispositions. The list of candidate causative variants for polyneuropathy needs to be further evaluated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through performing exosomal miRNA sequencing in HCC cells with different metastatic potentials (MHCC-97H and 97hm), many significantly different miRNA candidates were found. Among these miRNAs, miR-92a-3p was the most abundant miRNA in the exosomes of highly metastatic HCC cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study improves our knowledge of thermotolerance mechanisms in native grasses, and also provides candidate genes for potential applications in the genetic improvement of grasses.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…With this work, we hope (i) to assist the fast-paced biomedical research efforts to combat the virus by critically summarizing current knowledge on the potential role of host genetics, and (ii) to help guide current genetics and genomics research towards candidate gene variants that warrant further investigation in larger studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on its antiviral, anti-inflammatory and immunoregulatory activity in acute lung injury, SFJDC might be a promising candidate for the treatment of COVID-19. PURPOSE: To evaluate the antiviral and anti-inflammatory properties and to discover the mechanism of action of SFJDC as a potential drug for the treatment of COVID-19. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that A. euchroma candidate targets were significantly associated with several apoptosis and inflammation-related biological pathways, such as MAPK signaling, PI3K-Akt signaling, IL-17 signaling, and T cell receptor signaling pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We report here that δ-catenin, which is encoded by CTNND2, an autism candidate gene, directly interacts with the Ank domain of Shank3 at postsynaptic sites through its Armadillo-repeat domain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As a proof of principle of a future vector saliva-based pan-Leishmania vaccine, we engineered through a reverse vaccinology approach that maximizes translation to humans, a fusion protein consisting of immunogenic portions of PdSP15 and LJL143, sand fly salivary proteins demonstrated as potential vaccine candidates against cutaneous and visceral leishmaniasis, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our results indicated that BCYRN1 exerted tumor suppressor potential and might be a candidate in the diagnosis and treatment of glioma.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AJSAF might be a safe and efficacious adjuvant candidate for H9N2 avian influenza vaccine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12917-020-02648-1.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Several hormones such as apelin, glucagon, insulin, aldosterone, the gonadotrophin releasing hormone and the thyroid hormone were also identified, and these should be tested in future studies as candidate biomarkers for feed efficiency. CONCLUSIONS: The combination of network and pathway analyses at the sequence level led to the identification of both common and specific mechanisms that are involved in RFI, RG and FE, and to a better understanding of the genetic determinism underlying these three criteria. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso