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  1. 131761
    “…Finally, five ginsenosides candidates with high inhibition potency were screened from the natural chemical library to be used as TMPRSS2 inhibitors. …”
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    Ginsenosides, potential TMPRSS2 inhibitors, a trade-off between the therapeutic combination for anti-PD-1 immunotherapy and the treatment of COVID-19 infection of LUAD patients
  2. 131762
    “…These findings reinforce the importance of inherited nucleotide variants involved in cisplatin metabolism as candidate variables for predictive models of adverse events. …”
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    Association of Clinical Aspects and Genetic Variants with the Severity of Cisplatin-Induced Ototoxicity in Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study
  3. 131763
    “…Thus, isolate B. flexus is a highly promising candidate for the production of industrial-size quantities of PHB from agricultural wastes and is capable of removing the environmental concerns associated with synthetic plastics from the industrial production process. …”
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    Characterization and Process Optimization for Enhanced Production of Polyhydroxybutyrate (PHB)-Based Biodegradable Polymer from Bacillus flexus Isolated from Municipal Solid Waste Landfill Site
  4. 131764
    “…Herein, we revealed novel candidate genes that influence pGCs apoptosis and cell cycle and provided new insights into the role of CDKN1A in pGCs during apoptosis and cell cycle arrest.…”
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    2,5-Hexanedione Affects Ovarian Granulosa Cells in Swine by Regulating the CDKN1A Gene: A Transcriptome Analysis
  5. 131765
    “…Bubble wrap, with very lightweight and waterproofing, could be a good candidate for mattress replacement. This study aimed to investigate the improvement in body pressure distribution and pressure-sensing area when using bubble wrap. …”
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    Comparison of body pressure distribution in healthy subjects between bubble wrap and an emergency mattress laid on a cardboard bed: a randomized controlled crossover trial
  6. 131766
    “…Weighted gene co-expression network analysis was performed to identify the most relevant ferroptosis-related and immune-related gene modules, which facilitated the identification of 327 ferroptosis gene and 306 immune gene candidates. A 4-gene (WAS, CORT, WNT16, and GLB1L2) signature was constructed and valuation using the least absolute shrinkage and selection operator-Cox regression models to effectively predict OS prognosis. …”
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    Integrative analyses of ferroptosis and immune related biomarkers and the osteosarcoma associated mechanisms
  7. 131767
    “…The further TIDE analysis indicated that high-risk patients had a lower TIDE score than that of low-risk patients, indicating that high-risk patients may be appropriate candidates for immunotherapy. CONCLUSIONS: For the first time, this study constructed and validated a prognostic predictive signature of LUAD patients based on TNF-related lncRNAs, and the signature showed good performance to predict immunotherapy response. …”
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    Tumor necrosis factor-related lncRNAs predict prognosis and immunotherapy response for patients with lung adenocarcinoma
  8. 131768
    “…More than 80% of breast cancer patients have an HR+ phenotype and are candidates for ET, but approximately half discontinue or become non-adherent by five years. …”
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    Motivational Interviewing Counseling to Increase Endocrine Therapy Adherence in Diverse Patients
  9. 131769
    “…CONCLUSIONS: Given that the subjects with SZ or SAD, along with most other diagnostic groups examined, had lower postsurgical mortality than PD subjects, it is reasonable to apply existing ethical and clinical guidelines to identify appropriate surgical candidates for inclusion of these patient populations in DBS clinical trials.…”
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    Postsurgical morbidity and mortality favorably informs deep brain stimulation for new indications including schizophrenia and schizoaffective disorder
  10. 131770
    “…Furthermore, the analysis of drug-hub gene interactions predicted TIPLASININ, CARLUMAB and BINDARIT as candidate drugs for SSc.…”
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    Bioinformatics-integrated screening of systemic sclerosis-specific expressed markers to identify therapeutic targets
  11. 131771
    “…Therefore, glucosylated Rhodanines may be useful as potential therapeutic candidates against cancer because of their topoisomerase II and DNA intercalation activity.…”
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    Design, Synthesis, Computational Investigations, and Antitumor Evaluation of N-Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells
  12. 131772
    “…Reconstruction parameter sets with the smallest RMSE and RC values within 10% bias were identified as the best candidate for harmonization. The coefficient of variation of the mean value of RCs (CV(MRC)) shows a remarkable reduction of about 28%, 26%, 32%, and 19% in harmonized reconstruction settings for MRC(max), MRC(ISO-50), MRC(peak), and MRC(10V), respectively. …”
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    Multicenter quantitative (18)F-fluorodeoxyglucose positron emission tomography performance harmonization: use of hottest voxels towards more robust quantification
  13. 131773
    “…The mixed ligand complexes having imidazole as secondary ligand displayed relatively high FCsp(3), indicating their potential as lead candidates. [Zn(C(8)H(9)N(3)OS)(PPh(3))(2)(SO(4))] and [Cu(C(8)H(9)N(3)OS)(im)(2)(SO(4))] exhibited appreciable binding affinity against the selected proteins. …”
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    Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone as Primary Ligand
  14. 131774
    “…This study identified 10 potential known miRNAs, namely, ccr-miR-10b, ccr-miR-122, ccr-miR-143, ccr-miR-146a, ccr-miR-155, ccr-miR-16c, ccr-miR-200a, ccr-miR-29a, ccr-miR-34, and ccr-miR-375, as candidates participating in modulating the liver insulin resistance. …”
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    Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio) fed with a high-starch diet
  15. 131775
    “…Our objective was to develop updated percentiles, based on substantially larger samples than previous norms, to more finely discriminate age- and sex-specific UPSIT performance among ≥50-year-old adults who may be candidates for studies of prodromal neurodegenerative diseases. …”
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    Updated Percentiles for the University of Pennsylvania Smell Identification Test in Adults 50 Years of Age and Older
  16. 131776
    “…Here, we highlight vaccine candidates that apply these approaches against SARS-CoV-2 in different ways. …”
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    Application of Traditional Vaccine Development Strategies to SARS-CoV-2
  17. 131777
    “…ABSTRACT: Paraplegic patients have always been ideal candidates for physiotherapy due to their body’s inability to recover on its own. …”
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    Recovery of Spinal Walking in Paraplegic Dogs Using Physiotherapy and Supportive Devices to Maintain the Standing Position
  18. 131778
    “…In this study, to modify the optimum pH of BsNox, fifteen relevant candidates of site-directed mutations were selected based on surface charge rational design. …”
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    N20D/N116E Combined Mutant Downward Shifted the pH Optimum of Bacillus subtilis NADH Oxidase
  19. 131779
    “…Such haplotypes, in which each individual variant alone is considered a benign polymorphism, are potential candidates for other hereditary diseases with causes of missing genetic defects.…”
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    Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism
  20. 131780
    “…CONCLUSION: This study demonstrated that candidates who successfully match into an orthopaedic surgery residency program achieve high academic performance, regardless of whether the program was affiliated with an allopathic medical school. …”
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    Diversity in Orthopaedic Surgery Residencies Based on Allopathic Medical School Affiliation
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