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  1. 131881
    “…We expect this model to enable long-sought investigations into cALD mechanisms and accelerate development of candidate therapies for lesion prevention, cessation, and remyelination.…”
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    A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis
  2. 131882
    “…IGF-1/IGF-1R axis has been proposed as a therapeutic candidate against the pathophysiological progress of diabetic cardiomyopathy (DCM). …”
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    Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
  3. 131883
    “…CONCLUSIONS: This newly obtained isolate was found to be new a strain based on comparative genomic analysis and it was also observed as a potential candidate for PHA biosynthesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s43141-023-00578-7.…”
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    De novo assembly and comparative genome analysis for polyhydroxyalkanoates-producing Bacillus sp. BNPI-92 strain
  4. 131884
    “…CONCLUSION: The developed nomogram_CHS had satisfactory prognostic accuracy in NPC patients and may individualize risk estimation to facilitate the identification of suitable IC candidates.…”
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    A Novel Prognostic Model Predicts Outcomes in Non-Metastatic Nasopharyngeal Carcinoma Based on Inflammation, Nutrition, and Coagulation Signature
  5. 131885
    “…These results highlight the need for health system-level surveillance and can guide discussion regarding administration of candidate RSV vaccines and immunoprophylaxis and assessment of their impact. …”
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    2643. Seasonality of infant respiratory syncytial virus associated bronchiolitis around the US since the onset of COVID-19: Results from four US health systems 2016-2023
  6. 131886
    “…BACKGROUND: Invasive meningococcal disease (IMD) serogroups A, B, C, W, Y are commonly prevented by MenACWY and MenB vaccines. MenABCWY candidate vaccines could potentially provide benefits as less injections, simplified schedules, and increased uptake. …”
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    1150. Invasive meningococcal disease vaccination – a targeted literature review of adolescents and parents/caregivers’ preferences
  7. 131887
    “…The subjective feedback was positive, highlighting the overall usefulness of the course and that the tailored complexity of each simulation scenario was appropriate to each candidate's prior level of experience. Trainees also reported feeling more confident in starting their anesthesia on-calls. …”
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    Perioperative Pain Management Simulation Course: Improving Anesthesia Trainees’ Confidence in the Management of Perioperative Pain and the Associated Critical Incidents
  8. 131888
    “…This study demonstrated that CD8(+) T cells specific for large numbers of HIV-1 epitopes were maintained in an epitope-dependent fashion under long-term cART and implied that some HIV-1-specific T cells are still candidates as effector cells for curative treatment. …”
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    Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8(+) T cells
  9. 131889
    “…In our search for a better dengue vaccine candidate, live attenuated strains were followed by non-infectious virus-like particles or the plasmids that generate these particles upon injection into the body. …”
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    Heterologous prime-boost immunization induces protection against dengue virus infection in cynomolgus macaques
  10. 131890
    “…Binary logistic regression was used to select candidate variables for multivariate analysis. Multivariate analysis was performed to identify associations between the dependent and independent factors. …”
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    Completion of the Maternal Health Care Continuum—Barriers and Facilitators Among Pregnant Women in Jimma Zone, Southwest Ethiopia: A Prospective Study
  11. 131891
    “…We propose that future studies should (a) investigate the mechanisms that underlie the apparent link between physiological adaptation and gene expression and (b) use the genes profiled in this paper as candidates for population genetic studies.…”
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    Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans
  12. 131892
    “…It gives additional information to better define a candidate region involved in the regulation of CD8+ T-lymphocyte numbers. …”
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    A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload
  13. 131893
    “…We did not identify methodological research that addressed this question, but based on logical arguments and the experience of other organisations we recommend that as many relevant stakeholder groups as practical should be consulted to identify suitable candidates with an appropriate mix of perspectives, technical skills and expertise, as well as to obtain a balanced representation with respect to regions and gender. …”
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    Improving the use of research evidence in guideline development: 3. Group composition and consultation process
  14. 131894
    “…BACKGROUND: The ease by which the Internet is able to distribute information to geographically-distant users on a wide variety of computers makes it an obvious candidate for a technological solution for electronic patient record systems. …”
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    Internet Patient Records: new techniques
  15. 131895
    “…In the presence of NK(1)R, Nkx2-5 _01 was significantly correlated with 36 transcripts which included several candidates for mediating bladder development (FGF) and inflammation (PAR-3, IL-1R, IL-6, α-NGF, TSP2). …”
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    Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements
  16. 131896
    “…ERβ2/ERβcx acts as a dominant negative inhibitor of ERα and expression of ERβ2 mRNA has been proposed as a candidate marker for outcome in primary breast cancer following adjuvant endocrine therapy. …”
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    Association of oestrogen receptor beta 2 (ERβ2/ERβcx) with outcome of adjuvant endocrine treatment for primary breast cancer – a retrospective study
  17. 131897
    “…Of the various genes mapping to the commonly deleted sequence, the best candidate as a 'target' seems to be the p53 antioncogene. …”
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    Increased p53 protein content of colorectal tumours correlates with poor survival.
  18. 131898
    “…In the analysis of selected candidate genes, SNP associations (FBAT or GEE p-value < 0.01) were identified for age at death in or near the following genes: FOXO1A, GAPDH, KL, LEPR, PON1, PSEN1, SOD2, and WRN. …”
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    Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
  19. 131899
    “…Polymorphisms within 28 of 163 candidate genes for stroke, AD and memory impairment were associated with the endophenotypes studied at p < 0.001. …”
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    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study
  20. 131900
    “…In relating 100K SNPs to known candidate genes, we identified two SNPs (rs1582055, rs4897475) in erythrocyte membrane protein band 4.1-like 2 (EPB41L2) associated with hematological phenotypes (GEE p < 10(-3)). …”
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    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
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