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131921“…Thus there is an indispensable need for exploration of novel natural products as antitumor drug candidates. The present work supports the mammalian proteasomes inhibiting activity of WA along with elucidation of its possible mode of action. …”
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131922por Ueno, Saneyoshi, Le Provost, Grégoire, Léger, Valérie, Klopp, Christophe, Noirot, Céline, Frigerio, Jean-Marc, Salin, Franck, Salse, Jérôme, Abrouk, Michael, Murat, Florent, Brendel, Oliver, Derory, Jérémy, Abadie, Pierre, Léger, Patrick, Cabane, Cyril, Barré, Aurélien, de Daruvar, Antoine, Couloux, Arnaud, Wincker, Patrick, Reviron, Marie-Pierre, Kremer, Antoine, Plomion, Christophe“…The EST catalogue was examined for putative homologs of candidate genes involved in bud phenology, cuticle formation, phenylpropanoids biosynthesis and cell wall formation. …”
Publicado 2010
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131923por Catena, Fausto, Di Saverio, Salomone, Kelly, Michael D, Biffl, Walter L, Ansaloni, Luca, Mandalà, Vincenzo, Velmahos, George C, Sartelli, Massimo, Tugnoli, Gregorio, Lupo, Massimo, Mandalà, Stefano, Pinna, Antonio D, Sugarbaker, Paul H, Van Goor, Harry, Moore, Ernest E, Jeekel, Johannes“…These patients are good candidates for Water Soluble Contrast Medium (WSCM) with both diagnostic and therapeutic purposes. …”
Publicado 2011
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131924por Gonzalez, Ana Maria, Podvin, Sonia, Lin, Shuh-Yow, Miller, Miles C, Botfield, Hannah, Leadbeater, Wendy E, Roberton, Andrew, Dang, Xitong, Knowling, Stuart E, Cardenas-Galindo, Elena, Donahue, John E, Stopa, Edward G, Johanson, Conrad E, Coimbra, Raul, Eliceiri, Brian P, Baird, Andrew“…Together with ventricular ependymal cells, these CPe relay homeostatic signals throughout the central nervous system (CNS) and regulate CSF hydrodynamics. One new candidate signal is augurin, a newly recognized 14 kDa protein that is encoded by esophageal cancer related gene-4 (Ecrg4), a putative tumor suppressor gene whose presence and function in normal tissues remains unexplored and enigmatic. …”
Publicado 2011
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131925por Chai, Yubo, Lee, Hyo-Jeong, Shaik, Ahmad Ali, Nkhata, Katai, Xing, Chengguo, Zhang, Jinhui, Jeong, Soo-Jin, Kim, Sung-Hoon, Lü, Junxuan“…CONCLUSIONS: Our in vitro and in vivo data support PGG as a potential drug candidate for breast cancer with novel targeting actions, especially for a triple negative BCa xenograft model.…”
Publicado 2010
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131926por Altenburg, Jeffrey D, Bieberich, Andrew A, Terry, Colin, Harvey, Kevin A, VanHorn, Justin F, Xu, Zhidong, Jo Davisson, V, Siddiqui, Rafat A“…BACKGROUND: Breast cancer is a collection of diseases in which molecular phenotypes can act as both indicators and mediators of therapeutic strategy. Therefore, candidate therapeutics must be assessed in the context of multiple cell lines with known molecular phenotypes. …”
Publicado 2011
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131927por Yang, Jennie HM, Downes, Kate, Howson, Joanna MM, Nutland, Sarah, Stevens, Helen E, Walker, Neil M, Todd, John A“…Here, we have conducted association analysis of this candidate gene region, and then investigated potential correlations between the most T1D-associated variant and RNA expression of the SLC11A1 gene and its splice isoform. …”
Publicado 2011
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131928por Hensley, Monica R, Emran, Farida, Bonilla, Sylvia, Zhang, Liyun, Zhong, Wenxuan, Grosu, Paul, Dowling, John E, Leung, Yuk Fai“…Hence, the significant genes from the microarray study are good candidates for cell-type specific markers and will aid further investigation of retinal differentiation.…”
Publicado 2011
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131929por Giessen, Clemens, von Weikersthal, Ludwig Fischer, Hinke, Axel, Stintzing, Sebastian, Kullmann, Frank, Vehling-Kaiser, Ursula, Mayerle, Julia, Bangerter, Markus, Denzlinger, Claudio, Sieber, Markus, Teschendorf, Christian, Freiberg-Richter, Jens, Schulz, Christoph, Modest, Dominik Paul, Moosmann, Nicolas, Aubele, Philipp, Heinemann, Volker“…CONCLUSION: The AIO KRK 0110 trial is designed for patients with disseminated, but asymptomatic mCRC who are not potential candidates for surgical resection of metastasis. Two bevacizumab-based strategies are compared: one starting as single-agent chemotherapy (Cape-Bev) allowing escalation to CAPIRI-Bev and another starting with combination chemotherapy (CAPIRI-Bev) and allowing de-escalation to Cape-Bev and subsequent re-escalation if necessary. …”
Publicado 2011
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131930por Cole, John B, Wiggans, George R, Ma, Li, Sonstegard, Tad S, Lawlor, Thomas J, Crooker, Brian A, Van Tassell, Curtis P, Yang, Jing, Wang, Shengwen, Matukumalli, Lakshmi K, Da, Yang“…RESULTS: Genome-wide association analysis identified a number of candidate genes and chromosome regions associated with 31 dairy traits in contemporary U.S. …”
Publicado 2011
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131931por Harvard, Chansonette, Strong, Emma, Mercier, Eloi, Colnaghi, Rita, Alcantara, Diana, Chow, Eva, Martell, Sally, Tyson, Christine, Hrynchak, Monica, McGillivray, Barbara, Hamilton, Sara, Marles, Sandra, Mhanni, Aziz, Dawson, Angelika J, Pavlidis, Paul, Qiao, Ying, Holden, Jeanette J, Lewis, Suzanne ME, O'Driscoll, Mark, Rajcan-Separovic, Evica“…Here we described the consequences of the 1q21.1 CNV on genome-wide gene expression and function of selected candidate genes within 1q21.1 using cell lines from clinically well described subjects. …”
Publicado 2011
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131932“…Some of these genes may be candidates for improving NUE. These findings will help to provide a detailed understanding of NUE mechanisms, and also provide a basis for breeding soybean varieties that are tolerant to low-N conditions.…”
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131933por Fortes, Ana M, Agudelo-Romero, Patricia, Silva, Marta S, Ali, Kashif, Sousa, Lisete, Maltese, Federica, Choi, Young H, Grimplet, Jerome, Martinez- Zapater, José M, Verpoorte, Robert, Pais, Maria S“…Some of these genes were annotated as receptors, transcription factors, and kinases and constitute good candidates for functional analysis in order to establish a model for ripening control of a non-climacteric fruit.…”
Publicado 2011
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131934por Shackleford, Terry J, Zhang, Qingxiu, Tian, Ling, Vu, Thuy T, Korapati, Anita L, Baumgartner, Angela M, Le, Xiao-Feng, Liao, Warren S, Claret, Francois X“…INTRODUCTION: The c-Jun coactivator, Jun activation-domain binding protein 1 (Jab1) also known as the fifth component of the COP9 signalosome complex (CSN5), is a novel candidate oncogene whose aberrant expression contributes to the progression of breast carcinoma and other human cancers. …”
Publicado 2011
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131935por Pontifex, Eliza K, Gerlag, Danielle M, Gogarty, Martina, Vinkenoog, Marjolein, Gibbs, Adrian, Burgman, Ilse, Fearon, Ursula, Bresnihan, Barry, Tak, Paul Peter, Gibney, Robin G, Veale, Douglas J, FitzGerald, Oliver“…This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, which has established guidelines for biomarker validation. To seek a candidate synovial biomarker of treatment response in psoriatic arthritis (PsA), we determined whether changes in immunohistochemical markers of synovial inflammation correlate with changes in disease activity scores assessing 28 joints (ΔDAS28) or magnetic resonance imaging synovitis scores (ΔMRI) in patients with PsA treated with a biologic agent. …”
Publicado 2011
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131936por Muranen, Taru A, Greco, Dario, Fagerholm, Rainer, Kilpivaara, Outi, Kämpjärvi, Kati, Aittomäki, Kristiina, Blomqvist, Carl, Heikkilä, Päivi, Borg, Åke, Nevanlinna, Heli“…Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. …”
Publicado 2011
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131937por Palma, Marco, Lopez, Lissett, García, Margarita, de Roja, Nuria, Ruiz, Tamara, García, Julita, Rosell, Elisabet, Vela, Carmen, Rueda, Paloma, Rodriguez, María-Jose“…BACKGROUND: Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 (NFE2L3) may be useful biomarker candidates for the diagnosis of colorectal cancer (CRC) since they have shown an increase messenger RNA transcripts (mRNA) expression level in adenomas and colorectal tumours when compared to normal tissues. …”
Publicado 2012
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131938por Xu, Xiaoming, Jin, Huiying, Liu, Yafang, Liu, Li, Wu, Qiong, Guo, Yaxiong, Yu, Lina, Liu, Zhijing, Zhang, Ting, Zhang, Xiaowei, Dong, Xueyan, Quan, Chengshi“…BACKGROUND: Claudin-6 is a candidate tumor suppressor gene in breast cancer, and has been shown to be regulated by DNA methylation and histone modification in breast cancer lines. …”
Publicado 2012
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131939por Falconar, Andrew K I“…PAbs generated against the dengue type-2 virus (DENV-2) nonstructural-1 (NS1) glycoprotein candidate vaccine also reacted with both DENV envelope (E) glycoproteins and blood-clotting proteins. …”
Publicado 2012
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131940por Nitta, Takayuki, Lee, Sangouk, Ha, Dat, Arias, Maribel, Kozak, Christine A, Fan, Hung“…Comparison of hAPOBEC3 isoforms expressed in different cell lines indicated that hA3B was the most likely candidate for a restrictive hA3. However over-expression of hA3B showed no enhanced restriction of infection by XMRV compared to MXMRV. …”
Publicado 2012
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