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1301por Butler, Merlin G., Rafi, Syed K., Hossain, Waheeda, Stephan, Dietrich A., Manzardo, Ann M.“…Heritability is estimated as high as 90% for ASD with a recently reported compilation of 629 clinically relevant candidate and known genes. We chose to undertake a descriptive next generation whole exome sequencing case study of 30 well-characterized Caucasian females with autism (average age, 7.7 ± 2.6 years; age range, 5 to 16 years) from multiplex families. …”
Publicado 2015
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1302por Delfani, Somayeh, Imani Fooladi, Abbas Ali, Mobarez, Ashraf Mohabati, Emaneini, Mohammad, Amani, Jafar, Sedighian, Hamid“…RESULTS: The proteins encoded by these genes were useful as vaccine candidates against S. aureus infections. CONCLUSION: In silico tools are highly suited to study, design, and evaluate vaccine strategies.…”
Publicado 2015
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1303
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1304“…Given the high variability in disease onset and progression, multiple factors could contribute to the pathogenesis of FSHD. Among the FSHD candidate genes are double homeobox 4 (DUX4), encoded by the most telomeric D4Z4 unit, and FSHD region gene 1 (FRG1). …”
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1306por Bulman, Christina A., Bidlow, Chelsea M., Lustigman, Sara, Cho-Ngwa, Fidelis, Williams, David, Rascón, Jr, Alberto A., Tricoche, Nancy, Samje, Moses, Bell, Aaron, Suzuki, Brian, Lim, K. C., Supakorndej, Nonglak, Supakorndej, Prasit, Wolfe, Alan R., Knudsen, Giselle M., Chen, Steven, Wilson, Chris, Ang, Kean-Hooi, Arkin, Michelle, Gut, Jiri, Franklin, Chris, Marcellino, Chris, McKerrow, James H., Debnath, Anjan, Sakanari, Judy A.Enlace del recurso
Publicado 2015
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1307por Frainais, Christophe, Kannengiesser, Caroline, Albert, Martine, Molina-Gomes, Denise, Boitrelle, Florence, Bailly, Marc, Grandchamp, Bernard, Selva, Jacqueline, Vialard, François“…These genes are therefore good candidates for explaining impairments in spermatogenesis. …”
Publicado 2014
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1308“…In this review we will describe advantages and limitations of the S-ICD and point-out how to select the “ideal candidate” for the implantation.…”
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1309por Pappou, Ioannis, Cammisa, Frank, Papadopoulos, Elias, Frelinghuysen, Peter, Girardi, Federico“…The purpose of this study was to ascertain what percentage of patients treated surgically for degenerative disc disease with other surgical procedures would have been candidates for nuclear replacement implantation. METHODS: The charts and films of 85 consecutive patients with failed conservative management for LBP treated surgically with fusion, disc replacement, or annuloplasty were retrospectively reviewed. …”
Publicado 2008
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1310“…Expression levels of candidate odorant receptors were estimated by read mapping and quantitative reverse transcription PCR. …”
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1311“…It is thus a major challenge to select only a few candidate disease-causing variants for experimental testing. …”
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1312por Poos, Kathrin, Smida, Jan, Maugg, Doris, Eckstein, Gertrud, Baumhoer, Daniel, Nathrath, Michaela, Korsching, Eberhard“…We identified an osteosarcoma network assembling well-known and lesser-known candidates. The derived network shows a significant connectivity and modularity suggesting that the genes affected by the heterogeneous genetic alterations share the same biological context. …”
Publicado 2015
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1313por Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.“…Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The clinical candidate (compound 12) is efficacious in a mouse model of Pf malaria with an ED(99) <30 mg kg(−1) and displays good in vivo safety margins in guinea pigs and rats. …”
Publicado 2015
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1314por Hebert, Francois Olivier, Phelps, Luke, Samonte, Irene, Panchal, Mahesh, Grambauer, Stephan, Barber, Iain, Kalbe, Martin, Landry, Christian R, Aubin-Horth, Nadia“…The three other candidates are involved in ion transport and post-translational protein modifications. …”
Publicado 2015
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1315por Bestetti, Reinaldo B.Enlace del recurso
Publicado 2014
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1317“…Working-memory training is a candidate computerized adjunctive intervention for the treatment of alcoholism and other drug dependencies. …”
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1318por Sheik Mohideen, Sahabudeen, Yamasaki, Yasutoyo, Omata, Yasuhiro, Tsuda, Leo, Yoshiike, Yuji“…Our findings indicate that singlet oxygen generators with little toxicity may be suitable drug candidates for treating tauopathies.…”
Publicado 2015
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1319por Terai, Tomohiko, Okumura, Takekazu, Imai, Susumu, Nakao, Masumi, Yamaji, Kazuaki, Ito, Masahiko, Nagata, Tsuyoshi, Kaneko, Kimiyuki, Miyazaki, Kouji, Okada, Ayako, Nomura, Yoshiaki, Hanada, Nobuhiro“…This study screened new probiotic candidates with potential oral health benefits and no harmful effects on the oral cavity. …”
Publicado 2015
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1320por Kapulu, M. C., Da, D. F., Miura, K., Li, Y, Blagborough, A. M., Churcher, T. S., Nikolaeva, D., Williams, A. R., Goodman, A. L., Sangare, I., Turner, A. V., Cottingham, M. G., Nicosia, A., Straschil, U., Tsuboi, T., Gilbert, S. C., Long, Carole A., Sinden, R. E., Draper, S. J., Hill, A. V. S., Cohuet, A., Biswas, S.“…Different vaccine platforms, mainly protein-in-adjuvant formulations delivering the leading candidate antigens, have been developed independently and have reported varied transmission-blocking activities (TBA). …”
Publicado 2015
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