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  1. 1301
    “…Heritability is estimated as high as 90% for ASD with a recently reported compilation of 629 clinically relevant candidate and known genes. We chose to undertake a descriptive next generation whole exome sequencing case study of 30 well-characterized Caucasian females with autism (average age, 7.7 ± 2.6 years; age range, 5 to 16 years) from multiplex families. …”
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    Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes
  2. 1302
    “…RESULTS: The proteins encoded by these genes were useful as vaccine candidates against S. aureus infections. CONCLUSION: In silico tools are highly suited to study, design, and evaluate vaccine strategies.…”
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    In silico analysis for identifying potential vaccine candidates against Staphylococcus aureus
  3. 1303
    Publicado 2015
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    Correction: Integrative Data Mining Highlights Candidate Genes for Monogenic Myopathies
  4. 1304
    “…Given the high variability in disease onset and progression, multiple factors could contribute to the pathogenesis of FSHD. Among the FSHD candidate genes are double homeobox 4 (DUX4), encoded by the most telomeric D4Z4 unit, and FSHD region gene 1 (FRG1). …”
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    Direct interplay between two candidate genes in FSHD muscular dystrophy
  5. 1305
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    Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep
  6. 1306
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    Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis
  7. 1307
    “…These genes are therefore good candidates for explaining impairments in spermatogenesis. …”
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    RHOXF2 gene, a new candidate gene for spermatogenesis failure
  8. 1308
    “…In this review we will describe advantages and limitations of the S-ICD and point-out how to select the “ideal candidate” for the implantation.…”
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    The Entirely Subcutaneous Defibrillator (S-Icd): State of the Art and Selection of the Ideal Candidate
  9. 1309
    “…The purpose of this study was to ascertain what percentage of patients treated surgically for degenerative disc disease with other surgical procedures would have been candidates for nuclear replacement implantation. METHODS: The charts and films of 85 consecutive patients with failed conservative management for LBP treated surgically with fusion, disc replacement, or annuloplasty were retrospectively reviewed. …”
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    Screening for Nuclear Replacement Candidates in Patients With Lumbar Degenerative Disc Disease
  10. 1310
    “…Expression levels of candidate odorant receptors were estimated by read mapping and quantitative reverse transcription PCR. …”
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    Identification of Candidate Odorant Receptors in Asian Corn Borer Ostrinia furnacalis
  11. 1311
    por Itan, Yuval, Casanova, Jean-Laurent
    Publicado 2015
    “…It is thus a major challenge to select only a few candidate disease-causing variants for experimental testing. …”
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    Novel Primary Immunodeficiency Candidate Genes Predicted by the Human Gene Connectome
  12. 1312
    “…We identified an osteosarcoma network assembling well-known and lesser-known candidates. The derived network shows a significant connectivity and modularity suggesting that the genes affected by the heterogeneous genetic alterations share the same biological context. …”
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    Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules
  13. 1313
    por Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.
    Publicado 2015
    “…Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The clinical candidate (compound 12) is efficacious in a mouse model of Pf malaria with an ED(99) <30 mg kg(−1) and displays good in vivo safety margins in guinea pigs and rats. …”
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    Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate
  14. 1314
    “…The three other candidates are involved in ion transport and post-translational protein modifications. …”
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    Identification of candidate mimicry proteins involved in parasite-driven phenotypic changes
  15. 1315
    por Bestetti, Reinaldo B.
    Publicado 2014
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    Psychological assessment before heart transplantation: more hope to candidates in Brazil?
  16. 1316
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    Pathways and Networks-Based Analysis of Candidate Genes Associated with Nicotine Addiction
  17. 1317
    “…Working-memory training is a candidate computerized adjunctive intervention for the treatment of alcoholism and other drug dependencies. …”
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    Computerized Working-Memory Training as a Candidate Adjunctive Treatment for Addiction
  18. 1318
    “…Our findings indicate that singlet oxygen generators with little toxicity may be suitable drug candidates for treating tauopathies.…”
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    Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies
  19. 1319
    “…This study screened new probiotic candidates with potential oral health benefits and no harmful effects on the oral cavity. …”
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    Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease
  20. 1320
    “…Different vaccine platforms, mainly protein-in-adjuvant formulations delivering the leading candidate antigens, have been developed independently and have reported varied transmission-blocking activities (TBA). …”
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    Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum
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