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  1. 132041
    por Boyer, Célia, Dolamic, Ljiljana
    Publicado 2015
    “…BACKGROUND: To earn HONcode certification, a website must conform to the 8 principles of the HONcode of Conduct In the current manual process of certification, a HONcode expert assesses the candidate website using precise guidelines for each principle. …”
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    Automated Detection of HONcode Website Conformity Compared to Manual Detection: An Evaluation
  2. 132042
    “…We focused on methylation of candidate genes related to coagulation and inflammation: coagulation factor III (F3), intercellular adhesion molecule 1 (ICAM-1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and toll-like receptor 2 (TRL-2). …”
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    Beyond the Mean: Quantile Regression to Explore the Association of Air Pollution with Gene-Specific Methylation in the Normative Aging Study
  3. 132043
    “…TaqMan microRNA assay was used to identify differentially expressed miRNAs in plasma of cohort of patients with AH versus controls followed by construction of receiver operating characteristic (ROC) curves to determine the sensitivity and specificity of the candidates. RESULTS: The total number of circulating EVs was significantly increased in mice after alcohol feeding. …”
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    Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
  4. 132044
    “…The trait is largely controlled by the Malic acid (Ma) locus, underpinning which Ma1 that putatively encodes a vacuolar aluminum-activated malate transporter1 (ALMT1)-like protein is a strong candidate gene. We hypothesize that fruit acidity is governed by a gene network in which Ma1 is key member. …”
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    Uncovering co-expression gene network modules regulating fruit acidity in diverse apples
  5. 132045
    “…The amidopyrimidine polymers exhibited remarkable antifungal and antibacterial activity and thus, these types of polymers are promising candidates for biomedical applications. CONCLUSIONS: The SEM analysis indicated that most of the polyamides were organized as well defined nano sized spheres, but in certain derivatives small amount of aggregated nanospheres were also observed. …”
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    Synthesis and biological evaluation of new nanosized aromatic polyamides containing amido- and sulfonamidopyrimidines pendant structures
  6. 132046
    “…ENO1 is a highly conserved protein, and could be a candidate molecule for molecular mimicry between bacterial and human proteins. …”
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    Association between anti-Porphyromonas gingivalis or anti-α-enolase antibody and severity of periodontitis or rheumatoid arthritis (RA) disease activity in RA
  7. 132047
    “…Prior to entry into the renal transplant wait list, potential candidates are screened for the presence of cardiovascular disease. …”
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    Risk factors for cardiovascular events among Asian patients without pre-existing cardiovascular disease on the renal transplant wait list
  8. 132048
    “…We applied a data reduction strategy to identify both common and rare/private somatic events with high functional potential. Top-ranked candidate mutations were subsequently validated at high sequencing depth on an independent platform and in vitro expression assays were performed to evaluate the impact of identified mutations on cell growth and survival. …”
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    A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells
  9. 132049
    “…Associated SNPs hit 36 annotated genes including function-matching candidates like cullin and GRF. The germplasm with elongated mesocotyl, especially upland landraces or varieties, and the associated SNPs could be useful in further studies and breeding of mechanized dry seeded rice. …”
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    Genome-wide Association Study (GWAS) of mesocotyl elongation based on re-sequencing approach in rice
  10. 132050
    “…Analysis of evolutionarily conserved transcription factor binding sites in the promoters of these genes revealed almost all known OXPHOS regulators (including GABP, NRF1/2, SP1, YY1, E-box factors) and a set of novel candidates (ELK1, KLF7, SP4, EHF, ZNF143, and TEL2). …”
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    Transcriptome analysis of complex I-deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system
  11. 132051
    “…CONCLUSIONS: These findings suggest that circulating miRNAs provide attractive candidates as putative biomarkers for diffuse myocardial fibrosis in HCM. …”
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    Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy
  12. 132052
    “…Importantly we report for the first time two new candidate miRNAs (miR-574-3p and miR-660-5p) as promising prognostic markers. …”
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    Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer
  13. 132053
    “…The results were compared with those obtained from an automated discovery of candidate biomedical tools. For the evaluation of the results, precision and recall measurements were used. …”
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    Semantic biomedical resource discovery: a Natural Language Processing framework
  14. 132054
    “…The inhibitory impacts of rSjCa8 on macrophage migration and [Ca(2+)](i)-dependent NO release suggest it might represent a novel vaccine candidate and chemotherapeutic target for the prevention and treatment of schistosomiasis. …”
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    SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages
  15. 132055
    “…CsaMLO8 was previously identified as a candidate susceptibility gene for PM in cucumber, for two reasons: 1) This gene clusters phylogenetically in clade V, which has previously been shown to harbour all known MLO-like susceptibility genes for PM identified in dicot species; 2) This gene co-localizes with a QTL on chromosome 5 for hypocotyl-specific resistance to PM. …”
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    A transposable element insertion in the susceptibility gene CsaMLO8 results in hypocotyl resistance to powdery mildew in cucumber
  16. 132056
    “…Furthermore, we detected several obesity candidate genes, for example, ENPP1, CTSL, and ABHD12B. …”
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    An integrative systems genetics approach reveals potential causal genes and pathways related to obesity
  17. 132057
    “…In addition, we illustrate the power of combining publicly available whole-genome databases with a candidate gene approach to study cancer epigenetics. …”
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    Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
  18. 132058
    “…Here, we test the hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC, p16, GADD45A) are associated with tumor recurrence and survival, in a well-characterized, prospective, cohort of 346 HNSCC patients. …”
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    NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas
  19. 132059
    “…Finally, systematic structural analysis of candidate point mutations (SNVs) suggests that such mutations frequently stabilize lncRNA structures instead of destabilizing them. …”
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    Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma
  20. 132060
    “…METHODS: Ten lncRNAs (HOTAIR, AFAP1-AS1, POU3F3, HNF1A-AS1, 91H, PlncRNA1, SPRY4-IT1, ENST00000435885.1, XLOC_013104 and ENST00000547963.1) which previously found to be differently expressed in esophageal cancer were selected as candidate targets for subsequent circulating lncRNA assay. …”
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    Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma
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