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132121por Sprague, Daniel A., Jeffery, Caroline, Crossland, Nadine, House, Thomas, Roberts, Gareth O., Vargas, William, Ouma, Joseph, Lwanga, Stephen K., Valadez, Joseph J.“…We use this model together with known demographics to formulate a nascent early warning system that identifies candidate districts expected to have low prevalence of facility-based delivery in the immediate future. …”
Publicado 2016
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132122por do Nascimento, Ticiano Gomes, da Silva, Priscilla Fonseca, Azevedo, Lais Farias, da Rocha, Louisianny Guerra, de Moraes Porto, Isabel Cristina Celerino, Lima e Moura, Túlio Flávio Accioly, Basílio-Júnior, Irinaldo Diniz, Grillo, Luciano Aparecido Meireles, Dornelas, Camila Braga, Fonseca, Eduardo Jorge da Silva, de Jesus Oliveira, Eduardo, Zhang, Alex Tong, Watson, David G.“…Red propolis extract loaded in nanoparticles has shown to be potential candidates as intermediate products for preparation of various pharmaceutical dosage forms containing red propolis extract in the therapy against negligible diseases such as leishmaniasis. …”
Publicado 2016
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132123por Stelzer, Gil, Plaschkes, Inbar, Oz-Levi, Danit, Alkelai, Anna, Olender, Tsviya, Zimmerman, Shahar, Twik, Michal, Belinky, Frida, Fishilevich, Simon, Nudel, Ron, Guan-Golan, Yaron, Warshawsky, David, Dahary, Dvir, Kohn, Asher, Mazor, Yaron, Kaplan, Sergey, Iny Stein, Tsippi, Baris, Hagit N., Rappaport, Noa, Safran, Marilyn, Lancet, Doron“…Thus, a major challenge is to transition from the few hundred shortlisted genes to the most viable disease-causing candidates. RESULTS: We describe a novel tool, VarElect (http://ve.genecards.org), a comprehensive phenotype-dependent variant/gene prioritizer, based on the widely-used GeneCards, which helps rapidly identify causal mutations with extensive evidence. …”
Publicado 2016
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132124“…Hypertensive individuals eager to change health behaviors are excellent candidates for mobile health self-monitoring.. TRIAL REGISTRATION: ClinicalTrials.gov NCT01975428, https://clinicaltrials.gov/ct2/show/NCT01975428 (Archived by WebCite at http://www.webcitation.org/6iSO5OgOG)…”
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132125por Panni, Tommaso, Mehta, Amar J., Schwartz, Joel D., Baccarelli, Andrea A., Just, Allan C., Wolf, Kathrin, Wahl, Simone, Cyrys, Josef, Kunze, Sonja, Strauch, Konstantin, Waldenberger, Melanie, Peters, Annette“…DNA methylation has been identified as a possible link but so far it has only been analyzed in candidate sites. OBJECTIVES: We studied the association between DNA methylation and short- and mid-term air pollution exposure using genome-wide data and identified potential biological pathways for additional investigation. …”
Publicado 2016
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132126“…Structural modeling suggested that FvXyn11A and FvXyn11B could be blocked by XIP-I that serves as good candidate for developing transgenic soybeans. In contrast, one GH28 PG, FvPG2, contains an amino acid substitution that is potentially incompatible with the bean polygalacturonase-inhibitor protein II (PvPGIP2). …”
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132127por Mauri, Lucia, Uebe, Steffen, Sticht, Heinrich, Vossmerbaeumer, Urs, Weisschuh, Nicole, Manfredini, Emanuela, Maselli, Edoardo, Patrosso, Mariacristina, Weinreb, Robert N., Penco, Silvana, Reis, André, Pasutto, Francesca“…However, mutations in these genes explain only a small fraction of cases suggesting the presence of further candidate genes. METHODS: To elucidate further genetic causes of these conditions whole exome sequencing (WES) was performed in an Italian patient, diagnosed with PCG and retinal detachment, and his unaffected parents. …”
Publicado 2016
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132128por Seegers, Joachim, Conen, David, Jung, Klaus, Bergau, Leonard, Dorenkamp, Marc, Lüthje, Lars, Sohns, Christian, Sossalla, Samuel T., Fischer, Thomas H., Hasenfuss, Gerd, Friede, Tim, Zabel, Markus“…These data may pertain to individually improved selection of defibrillator candidates using risk factors, e.g. sex as demonstrated in this study.…”
Publicado 2016
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132129“…We propose that the IGF1 and HMGA2 loci are candidates for identical variation being associated with both behavior and morphology. …”
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132130por Casais, Rosa, Granda, Victor, Balseiro, Ana, del Cerro, Ana, Dalton, Kevin P., González, Roxana, Bravo, Pablo, Prieto, J. M., Montoya, Maria“…The purpose of this study was first to identify Sarcoptes scabiei immunodominant antigens and second to evaluate them as vaccine candidates in a rabbit/S. scabiei var. cuniculi model. …”
Publicado 2016
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132131por Babski, Julia, Haas, Karina A., Näther-Schindler, Daniela, Pfeiffer, Friedhelm, Förstner, Konrad U., Hammelmann, Matthias, Hilker, Rolf, Becker, Anke, Sharma, Cynthia M., Marchfelder, Anita, Soppa, Jörg“…The other types of novel non-coding transcripts corresponded to internal transcripts overlapping with mRNAs (1153 iTSSs) and intergenic small RNA (sRNA) candidates (395 TSSs). CONCLUSION: This study provides a comprehensive map of the primary transcriptome of Hfx. volcanii grown under optimal conditions. …”
Publicado 2016
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132132“…Escherichia coli are now one of the most important succinate producing candidates. However, the stoichiometric maximum succinate yield under anaerobic conditions through the reductive branch of the TCA cycle is restricted by NADH supply in E. coli. …”
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132133por Takahashi, Naoki, Iwasa, Satoru, Taniguchi, Hirokazu, Sasaki, Yusuke, Shoji, Hirokazu, Honma, Yoshitaka, Takashima, Atsuo, Okita, Natsuko, Kato, Ken, Hamaguchi, Tetsuya, Shimada, Yasuhiro, Yamada, Yasuhide“…Here we investigated associations between the expression of other candidate prognostic biomarkers and outcome in mCRC patients receiving similar treatment. …”
Publicado 2016
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132134por Svoboda, Martin, Meshcheryakova, Anastasia, Heinze, Georg, Jaritz, Markus, Pils, Dietmar, Castillo-Tong, Dan Cacsire, Hager, Gudrun, Thalhammer, Theresia, Jensen-Jarolim, Erika, Birner, Peter, Braicu, Ioana, Sehouli, Jalid, Lambrechts, Sandrina, Vergote, Ignace, Mahner, Sven, Zimmermann, Philip, Zeillinger, Robert, Mechtcheriakova, Diana“…RESULTS: We structured the study by three consecutive analytical modules, which include the multigene-based expression profiling in a cohort of patients with primary serous ovarian cancer using a self-created AID/APOBEC-associated gene signature, building up of multivariable survival models with high predictive accuracy and nomination of top-ranked candidate/target genes according to their prognostic impact, and systems biology-based reconstruction of the AID/APOBEC-driven disease-relevant mechanisms using transcriptomics data from ovarian cancer samples. …”
Publicado 2016
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132135por Islam, Md Aminul, Große-Brinkhaus, Christine, Pröll, Maren Julia, Uddin, Muhammad Jasim, Rony, Sharmin Aqter, Tesfaye, Dawit, Tholen, Ernst, Hölker, Michael, Schellander, Karl, Neuhoff, Christiane“…Results of this study suggest that APP, TRAF6, PIN1, FOS, CDKN1A and TNFAIP3 could be considered as potential candidate genes for PRRSV vaccine responsiveness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-016-2849-1) contains supplementary material, which is available to authorized users.…”
Publicado 2016
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132136por Hanson, Rochelle F., Schoenwald, Sonja, Saunders, Benjamin E., Chapman, Jason, Palinkas, Lawrence A., Moreland, Angela D., Dopp, Alex“…While research indicates that collaboration among child welfare and mental health services sectors improves availability and sustainment of EBTs for children, few implementation strategies designed specifically to promote and sustain inter-professional collaboration (IC) and inter-organizational relationships (IOR) have undergone empirical investigation. A potential candidate for evaluation is the Community-Based Learning Collaborative (CBLC) implementation model, an adaptation of the Learning Collaborative which includes strategies designed to develop and strengthen inter-professional relationships between brokers and providers of mental health services to promote IC and IOR and achieve sustained implementation of EBTs for children within a community. …”
Publicado 2016
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132137por Chow, Wei Zhen, Bon, Abdul Hamid, Keating, Sheila, Anderios, Fread, Halim, Hazwan Abdul, Takebe, Yutaka, Kamarulzaman, Adeeba, Busch, Michael P., Tee, Kok Keng“…Detailed analysis identified similar recombinant structures with shared parental strains among the B'/C and B'/G URFs, some of which were sequenced from recently infected individuals, indicating the possible emergence and on-going spread of foreign clades of CRF candidates among the local population. The findings demonstrate extensive molecular complexity of HIV-1 among the infected blood donors in Malaysia, driven in part by the increased spread of recently described CRFs and multiple introductions of previously unreported genotypes from highly prevalent countries.…”
Publicado 2016
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132138por Hannafon, Bethany N., Trigoso, Yvonne D., Calloway, Cameron L., Zhao, Y. Daniel, Lum, David H., Welm, Alana L., Zhao, Zhizhuang J., Blick, Kenneth E., Dooley, William C., Ding, W. Q.“…BACKGROUND: microRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression profiles. …”
Publicado 2016
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132139por Jimenez-Moyano, Esther, Ruiz, Alba, Kløverpris, Henrik N., Rodriguez-Plata, Maria T., Peña, Ruth, Blondeau, Caroline, Selwood, David L., Izquierdo-Useros, Nuria, Moris, Arnaud, Clotet, Bonaventura, Goulder, Philip, Towers, Greg J., Prado, Julia G.“…The nonhuman TRIM5 variants, rhesus TRIM5α (RhT5) and TRIM-cyclophilin A (TCyp), are attractive candidates owing to their potency in sensing HIV-1 and blocking its activity. …”
Publicado 2016
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132140por Shen-Gunther, Jane, Wang, Chiou-Miin, Poage, Graham M., Lin, Chun-Lin, Perez, Luis, Banks, Nancy A., Huang, Tim Hui-Ming“…Promoter methylation of four candidate tumor suppressor genes (adenylate cyclase 8 (ADCY8), cadherin 8, type 2 (CDH8), MGMT, and zinc finger protein 582 (ZNF582)) out of 48 genes screened was quantified by bisulfite-pyrosequencing of genomic DNA. …”
Publicado 2016
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