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  1. 132261
  2. 132262
    “…BACKGROUND: Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is one of leading blood stage malaria vaccine candidates. However, genetic variation and antigenic diversity identified in global PfAMA-1 are major hurdles in the development of an effective vaccine based on this antigen. …”
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  3. 132263
    “…Thus, ten beads targeting PITX1 exon 3 and three beads targeting lincRNA C5orf66-AS1 were identified as significant candidates. The mean methylation of these beads was used for further correlation and the median was employed for dichotomization. …”
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  4. 132264
    “…RESULTS: We identified cowpea orthologues of the core clock genes VunLHY, VunTOC1, VunGI and VunELF3, the protein storage genes VunLEG, VunLEGJ, and VunCVC as well as nine candidate reference genes used in RT-PCR. ELONGATION FACTOR 1-A (ELF1A) resulted the most suitable reference gene. …”
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  5. 132265
  6. 132266
  7. 132267
    “…CONCLUSION: These data suggest that Notch1 inhibition by DAPT can effectively alleviate the severity of mouse psoriasis-like skin inflammation by regulating the differentiation and function of Th17 cells, indicating that DAPT might be a potential therapeutic candidate for the treatment of psoriatic inflammation.…”
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  8. 132268
  9. 132269
    “…Of 43 cases who had array-comparative genomic hybridization (array-CGH), CNVs were reported in 13 (30%) with a median EMS of 8.5 (1.5–11). Candidate gene analysis using a limited seven-gene panel in 64 boys identified variants in 9 (14%) with a median EMS of 8 (1–9). …”
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  10. 132270
    “…The C-terminal 19 kDa domain of PvMSP1P is a potential vaccine candidate, however, no study has been conducted in the orthologous gene of P. knowlesi. …”
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  11. 132271
  12. 132272
    “…Moreover, numerous clinical trials in chronic pain revealed that PEA treatment is devoid of addiction potential, dose limiting side effects and psychoactive effects, rendering PEA an appealing candidate as antiepileptic compound or adjuvant. In the present study, we aimed at assessing antiepileptic properties of PEA in a mouse model of acute epileptic seizures induced by systemic administration of kainic acid (KA). …”
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  13. 132273
    “…A decision analysis model will be developed to simulate a randomized controlled trial comparing three interventional arms: (1) continuation of renal replacement therapy for patients who are considered non-suitable candidates for renal transplantation due to obesity, (2) transplant recipients undergoing open transplant surgery, and (3) transplant patients undergoing robotic-assisted renal transplantation. …”
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  14. 132274
  15. 132275
    “…Genotyping and the search for E6/E7 mRNA are among the possible candidates. METHODS: The study was carried out by means of an observational analysis of the data relative to 674 HR-HPV positive women who we had observed from January 2013 to June 2015; the data had been gathered in a database at the HPV Center of the University Hospital of Catania, Italy. …”
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  16. 132276
    “…METHODS: A total of fifty-four plasma samples were obtained from thirty-four marmosets that were inoculated with clinically-isolated DENV strains or DENV candidate vaccines, were used in this study. Plasma samples were obtained from marmosets after primary inoculation with DENV-2 infection, secondary inoculation with homologous or heterologous genotypes, and tertiary inoculation with heterologous DENV. …”
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  17. 132277
    “…BACKGROUND: Despite repeated outbreaks, in particular the devastating 2014–2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JIKI trial) but did not demonstrate a strong antiviral efficacy. …”
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  18. 132278
    “…There is a need to look beyond the usual candidates, to pool data both to support methodologically robust, large-scale investigations and to better account for cross-population variability.…”
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  19. 132279
    “…NR1 and NR2A-B are essential subunits of NMDAR, which are encoded by genes Grin1, Grin2A and Grin2B, and have been identified as candidate genes for psychiatric disorders. NMDARs dysfunction disrupts neural excitation and to contribute to the altered brain function underlying, especially in schizophrenia and other psychosis. …”
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  20. 132280
    por Geaghan, Michael, Cairns, Murray
    Publicado 2018
    “…Several miRNAs in males were found to significantly correlate with differentially expressed genes, including miR-1271-5p with schizophrenia candidate gene DGCR2. Furthermore, many differentially expressed genes and miRNAs have previously been linked to schizophrenia and neuronal function. …”
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