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  1. 132401
    “…In Aim 3, we will use a theory-based causal model to match the identified barriers and facilitators to potential strategies for deimplementation. Candidate strategies will be discussed with a panel of stakeholders from hospitals with high rates of overuse to assess feasibility and acceptability. …”
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    Measuring overuse of continuous pulse oximetry in bronchiolitis and developing strategies for large-scale deimplementation: study protocol for a feasibility trial
  2. 132402
    “…Goals were to provide in-depth analysis of differentially expressed genes (DEGs), characterize patient-to-patient heterogeneity, and identify candidate biomarkers. RESULTS: We identified 752 ALS-increased and 764 ALS-decreased DEGs (FDR < 0.10 with > 10% expression change). …”
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    ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia
  3. 132403
    “…CONCLUSIONS: HPV-33/HPV-58 E6/E7 gene polymorphisms and T/B cell epitopes of their reference and variant sequences were studied, and candidate epitopes were selected by bioinformatics techniques for therapeutic vaccine design for people in Southwest China. …”
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    Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China
  4. 132404
    “…This gene is a likely candidate for Rcr6. Subsequent analysis of the Rcr6 equivalent region based on a published B. nigra genome was performed. …”
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    Clubroot resistance gene Rcr6 in Brassica nigra resides in a genomic region homologous to chromosome A08 in B. rapa
  5. 132405
    “…METHODS: To discover biomarkers to predict individualized prognosis we introduce a new multi-omics (secreto-transcriptomics) method that identifies, in their oncogenically secreted states, candidate markers of BC subtypes whose genes bear patient-specific mRNA expression alterations of prognostic significance. …”
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    Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients
  6. 132406
    “…Fifty-three out of these 294 variants were selected as candidate splicing variants. All variants but one, were introduced into the minigene MGBR2_ex14-20 (with exons 14–20) by site-directed mutagenesis and assayed in MCF-7 cells. …”
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    Minigene Splicing Assays Identify 12 Spliceogenic Variants of BRCA2 Exons 14 and 15
  7. 132407
    “…TRIAL REGISTRATION: The study was registered at www.trialregister.nl (No: 5541). Candidate number: 23527, NTR number: NTR5541, Date registered NTR: 22-DECEMBER-2015. …”
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    A multifaceted hand hygiene improvement program on the intensive care units of the National Referral Hospital of Indonesia in Jakarta
  8. 132408
    “…Methods: For that, we searched databases for candidate variants and performed bioinformatic and functional tests on selected variants. …”
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    MON-219 In Silico and in Vitro Studies of Human 5α-Reductase Type II Variants in Search for Activating Variants Explaining Androgen Excess Reveal New Loss-Of-Function Variants
  9. 132409
    “…Purpose: The verification of efficacy of new drug candidates in primate models may address the translational gap between non-clinical and clinical studies and support the prediction of efficacy in humans. …”
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    MON-477 Octreotide and ONO-ST-468, a Novel and Potent Somatostatin Receptor Type-2 (SST2) Agonist, Suppress GH Hypersecretion in the Monkey
  10. 132410
    “…Although U-500 insulin is not FDA-approved for use in CSII and the ideal candidate should be intellectually able to deal with insulin pump therapy, this treatment was effective for our patient who required high insulin doses and failing other treatment regimen, achieving glycemic control and weight loss in six weeks. …”
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    MON-152 Less Is More: Human Regular U-500 Insulin
  11. 132411
    “…We conducted a Whole Exome Sequencing on 69 Caucasian women with sporadic POI and performed a bioinformatics analysis on a specific subset of 420 coherent candidate genes(1). We identified variations in about fifty genes potentially linked to POI, including new genes never described to be associated with the diseases aetiology, such as AuTophagy related Genes (ATG)(2), KHDRBS1 gene encoding an RNA-binding protein(3), NOTCH2 gene(4)... …”
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    MON-235 Bone Morphogenic Protein Receptor Variants: A New Cause of Primary Ovarian Insufficiency
  12. 132412
    “…Genome-wide association studies have identified several risk loci for PCOS; however, the identified candidate genes could explain less than 5% of PCOS heritability. …”
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    MON-207 Identification of Monogenic Causes of Polycystic Ovary Syndrome by High Throughput Sequencing
  13. 132413
    “…Surgery is the treatment of choice, with biochemical remission in 21-66%, but some patients are poor surgical candidates or refuse surgery, and permanent nerve injury and hypoparathyroidism are substantial complications. …”
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    MON-553 Nerve Injury after Ethanol Ablation of Thyroid Cancer Metastases to the Neck
  14. 132414
    “…A psychological assessment, found her to be an inappropriate candidate for surgery due to her intellectual difficulties limiting her ability to consent for surgery. …”
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    SAT-101 The Combination of Anti-Obesity Medications and Bariatric Surgery Can Be Effective in Resetting the Cerebral Adipostat in Individuals with Autism Suffering from Severe Obesity
  15. 132415
    “…To enhance LpXI catalytic activity, we performed random mutagenesis using error-prone polymerase chain reaction (PCR), which yielded two LpXI candidates, SS82 and SS92, that showed markedly improved fermentation performance. …”
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    Molecular evolutionary engineering of xylose isomerase to improve its catalytic activity and performance of micro-aerobic glucose/xylose co-fermentation in Saccharomyces cerevisiae
  16. 132416
    “…Thus, treatment for hypovitaminosis D might routinely be considered in bariatric surgery candidates, especially in those with characteristics identified as independent risk factors for vitamin D deficiency, such as higher BMI and being non-white. …”
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    SAT-117 Prevalence of Vitamin D Depletion and Associated Factors among Patients Undergoing Bariatric Surgery in Southern Brazil
  17. 132417
    “…Chen, the patients with a PTH higher than 1000pg/mL were candidates to surgery however, those patients had high risks of cardiovascular mortality and they received denosumab. …”
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    SAT-509 Denosumab Use in Tertiary Hiperparathyroidism with Fracture
  18. 132418
    “…Timing of parathyroidectomy in kidney transplant candidates with secondary hyperparathryroidism: effect of pretransplant versus early or late post-transplant parathyroidectomy. …”
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    SUN-LB085 Complicated Hungry Bone Syndrome Due to Tertiary Hyperparathyroidism in a Patient with Kidney Transplant: A Case to Remember
  19. 132419
    por Rodriguez, Aleida, Baim, Sanford
    Publicado 2019
    “…Due to severe cardiomyopathy, the patient was deemed a poor surgical candidate. Treatment with cinacalcet 30 mg daily was started and slowly titrated to 90 mg twice daily. …”
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    SUN-509 A Challenging Case of Symptomatic Primary Hyperparathyroidism during Pregnancy Treated with Cinacalcet
  20. 132420
    “…We used PSA value above 4 ng/dL as the threshold for the biopsy candidates. The relationship between pre-biopsy variables affecting the percentage of prostate cancer risk was evaluated, including age, prostate-specific antigen (PSA) level, and estimated prostate volume (EPV). …”
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    Systemic Inflammatory Response in Predicting Prostate Cancer: The Diagnostic Value of Neutrophil-To-Lymphocyte Ratio
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