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132621por Kibe, Maguta, Nair, Sudha K., Das, Biswanath, Bright, Jumbo M., Makumbi, Dan, Kinyua, Johnson, Suresh, L. M., Beyene, Yoseph, Olsen, Michael S., Prasanna, Boddupalli M., Gowda, Manje“…GWAS revealed 10 significantly (p < 9.5 × 10(–6)) associated SNPs distributed on chromosomes 1, 2, 6, 7, and 8, which individually explained 6–8% of phenotypic variance. A set of nine candidate genes co-located or in physical proximity to the significant SNPs with roles in plant defense against pathogens were identified. …”
Publicado 2020
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132622por de Almeida Fuzeta, Miguel, Bernardes, Nuno, Oliveira, Filipa D., Costa, Ana Catarina, Fernandes-Platzgummer, Ana, Farinha, José Paulo, Rodrigues, Carlos A. V., Jung, Sunghoon, Tseng, Rong-Jeng, Milligan, William, Lee, Brian, Castanho, Miguel A. R. B., Gaspar, Diana, Cabral, Joaquim M. S., da Silva, Cláudia Lobato“…EVs are derived from cell membranes, allowing high biocompatibility to target cells, while their small size makes them ideal candidates to cross biological barriers. Despite the promising potential of EVs for therapeutic applications, robust manufacturing processes that would increase the consistency and scalability of EV production are still lacking. …”
Publicado 2020
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132623“…However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. …”
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132624por Fernandes, Silke, Were, Vincent, Gutman, Julie, Dorsey, Grant, Kakuru, Abel, Desai, Meghna, Kariuki, Simon, Kamya, Moses R, ter Kuile, Feiko O, Hanson, Kara“…Dihydroartemisinin–piperaquine is a promising candidate. We aimed to estimate the cost-effectiveness of intermittent preventive treatment in pregnancy with dihydroartemisinin–piperaquine (IPTp-DP) versus IPTp-SP to prevent clinical malaria infection (and its sequelae) during pregnancy. …”
Publicado 2020
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132625por Nitz, Ulrike, Gluz, Oleg, Kreipe, Hans H., Christgen, Matthias, Kuemmel, Sherko, Baehner, Frederick L., Shak, Steven, Aktas, Bahriye, Braun, Michael, Lüdtke-Heckenkamp, Kerstin, Forstbauer, Helmut, Grischke, Eva-Maria, Nuding, Benno, Darsow, Maren, Schumacher, Claudia, Krauss, Katja, Malter, Wolfram, Thill, Marc, Warm, Mathias, Wuerstlein, Rachel, Kates, Ronald E., Harbeck, Nadia“…METHODS: The prospective WSG-ADAPT HR+/HER2− trial included patients with N0/N1 early BC who were candidates for adjuvant chemotherapy based on clinical–pathological criteria alone. …”
Publicado 2020
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132626“…Many glioblastoma cell lines and primary biopsies express high levels of disialoganglioside GD2 antigen, making it an excellent candidate for targeted cancer therapy. In this study, we prepared anti-GD2 Ab conjugated immunoliposomes (ImmuLipCP) for co-delivery of CPT-11 and panobinostat, which is intended for combination targeted chemotherapy. …”
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132627por Weinhäuser, Isabel, Pereira-Martins, Diego A., Ortiz, Cesar, Silveira, Douglas R., Simões, Luíse A. A., Bianco, Thiago M., Araujo, Cleide L., Koury, Luisa C., Melo, Raul A. M., Bittencourt, Rosane I., Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana B., Kerbauy, Fábio, Chauffaille, Maria de Lourdes, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, Peter, Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, Ammatuna, Emanuele, Lucena-Araujo, Antonio R., Schuringa, Jan Jacob, Rego, Eduardo M.“…These findings demonstrate that SLIT2 can be considered as a prognostic marker in APL, and a potential candidate for clinical studies of a more heterogeneous disease, such as AML. …”
Publicado 2020
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132628por Shrestha, Ankita, Mishra, Ajay Kumar, Matoušek, Jaroslav, Steinbachová, Lenka, Potěšil, David, Nath, Vishnu Sukumari, Awasthi, Praveen, Kocábek, Tomáš, Jakse, Jernej, Drábková, Lenka Záveská, Zdráhal, Zbyněk, Honys, David, Steger, Gerhard“…The present study provides essential insights into the transcriptional and translational dynamics of tobacco pollen, which further strengthens our understanding of plant-viroid interactions and support for future mechanistic studies directed at delineating the functional role of candidate factors involved in viroid elimination.…”
Publicado 2020
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132629“…Combining protein and RNA data by searching LC–MS/MS data against a customized protein database from RNA-Seq may produce a subset of alternatively spliced protein isoform candidates that have higher confidence. RESULTS: We developed a bioinformatics workflow to discover alternative splicing biomarkers from LC–MS/MS using RNA-Seq. …”
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132630por Xiao, Chunfang, Huang, Mengling, Gao, Jianhua, Wang, Zhen, Zhang, Denghong, Zhang, Yuanxue, Yan, Lei, Yu, Xiao, Li, Bo, Shen, Yanfen“…Here the specific accumulation of mitogen-activated protein kinase, Serine/threonine kinases, WRKY transcription played a positive role in E14 immunity against PI. The candidate proteins identified reported in this study will form the basis of future studies and may improve our understanding of the molecular mechanisms of late blight disease resistance in potato. …”
Publicado 2020
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132631por Wang, Hao-Yu, Cai, Zhong-Xing, Yin, Dong, Song, Wei-Hua, Feng, Lei, Gao, Run-Lin, Yang, Yue-Jin, Dou, Ke-Fei“…Conclusion: Among high-risk PCI patients with diabetes mellitus without an adverse event through 1 year, extending DAPT >1-year significantly reduced the risk of major adverse cardiac and cerebrovascular events without an increase in clinically relevant bleeding, suggesting that such high-risk diabetic patients may be good candidates for long-term DAPT.…”
Publicado 2020
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132632por Goldberg, Simon B, Imhoff-Smith, Theodore, Bolt, Daniel M, Wilson-Mendenhall, Christine D, Dahl, Cortland J, Davidson, Richard J, Rosenkranz, Melissa A“…Improvements in distress were associated with days of use. Candidate mediators (social connection, insight, rumination, defusion, and mindfulness) and moderators (baseline rumination, defusion, and empathy) of changes in distress were identified. …”
Publicado 2020
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132633“…UBE3A is an important candidate gene of autism spectrum disorder (ASD), which located at the 15q11–13 region and encodes ubiquitin-protein ligase E3A. …”
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132634por Polack, Fernando P., Thomas, Stephen J., Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Perez, John L., Pérez Marc, Gonzalo, Moreira, Edson D., Zerbini, Cristiano, Bailey, Ruth, Swanson, Kena A., Roychoudhury, Satrajit, Koury, Kenneth, Li, Ping, Kalina, Warren V., Cooper, David, Frenck, Robert W., Hammitt, Laura L., Türeci, Özlem, Nell, Haylene, Schaefer, Axel, Ünal, Serhat, Tresnan, Dina B., Mather, Susan, Dormitzer, Philip R., Şahin, Uğur, Jansen, Kathrin U., Gruber, William C.“…METHODS: In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2 vaccine candidate (30 μg per dose). BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine that encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. …”
Publicado 2020
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132635por Tu, Megan M., Ng, Terry L., De Jong, Florus C., Zuiverloon, Tahlita C.M., Fazzari, Francesco G.T., Theodorescu, Dan“…CONCLUSIONS: Currently no molecular biomarker is sufficiently mature for routine clinical use, while some candidates, or a combination show great promise and need further study.…”
Publicado 2019
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132636por Dhot, Justine, Ferron, Marine, Prat, Valentine, Persello, Antoine, Roul, David, Stévant, David, Guijarro, Damien, Piriou, Nicolas, Aillerie, Virginie, Erraud, Angélique, Toumaniantz, Gilles, Erfanian, Morteza, Tesse, Angela, Grabherr, Amandine, Tesson, Laurent, Menoret, Séverine, Anegon, Ignacio, Trochu, Jean‐Noël, Steenman, Marja, De Waard, Michel, Rozec, Bertrand, Lauzier, Benjamin, Gauthier, Chantal“…This rat model should be valuable for future preclinical evaluation of candidate drugs aimed at correcting diastolic dysfunction.…”
Publicado 2020
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132637por Lococo, Filippo, Sassorossi, Carolina, Nachira, Dania, Chiappetta, Marco, Petracca Ciavarella, Leonardo, Vita, Emanuele, Boldrini, Luca, Evangelista, Jessica, Cesario, Alfredo, Bria, Emilio, Margaritora, Stefano“…Thus, locally advanced (LA)-NSCLC patients with pathological complete response (pCR) are optimal candidates to undergo surgery after IT, achieving good to very good long-term survival. …”
Publicado 2020
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132638por Eun, Jung Woo, Seo, Chul Won, Baek, Geum Ok, Yoon, Moon Gyeong, Ahn, Hye Ri, Son, Ju A., Sung, Suna, Kim, Do Wan, Kim, Soon Sun, Cho, Hyo Jung, Cheong, Jae Youn“…Sixty-one miRs were significantly overexpressed among patients with metastatic HCC. Candidate miRs were selected through integrative analyses of two different public expression datasets, GSE67140 and The Cancer Genome Atlas liver hepatocellular carcinoma (TCGA_LIHC). …”
Publicado 2020
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132639por Asanuma, Kunihiro, Nakamura, Tomoki, Asanuma, Yumiko, Okamoto, Takayuki, Kakimoto, Takuya, Yada, Yuki, Hagi, Tomohito, Kita, Kouji, Nakamura, Koichi, Matsumine, Akihiko, Sudo, Akihiro“…CONCLUSION: High levels of TM mRNA may be a significant predictor of recurrence, metastasis, and a poor outcome in STS patients after 10 years. TM is a candidate molecular marker and may be clinically useful for devising a therapeutic treatment strategy by prediction of prognosis.…”
Publicado 2020
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132640“…METHODS: Using ICD-10 code B37.6 (Candidal Endocarditis) we identified 703 inpatients at 179 United States hospitals from October 2015 through April 2019. …”
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