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  1. 132681
    “…Our longitudinal data suggest that qMRI could represent a feasible technique for capturing microstructural changes induced by SMA in vivo and a candidate methodology for monitoring the effects of treatment, once replicated on a larger cohort.…”
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    Pilot Study on Quantitative Cervical Cord and Muscular MRI in Spinal Muscular Atrophy: Promising Biomarkers of Disease Evolution and Treatment?
  2. 132682
    “…We encourage ophthalmologists to utilize DALK in appropriate candidates to more fully utilize the scarce and potentially vision-restoring resource of donor corneal tissue.…”
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    Indications of Keratoplasty and Outcomes of Deep Anterior Lamellar Keratoplasty Compared to Penetrating Keratoplasty
  3. 132683
    “…Therefore, in this work we present a detailed quality assurance study of 5-fluorouracil (5FU) drug-eluting stents (DESs) as potential candidates for the treatment of obstructive GI cancers. …”
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    Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions
  4. 132684
    “…This may ameliorate early identification of individuals who are candidates for appropriate therapeutic interventions aimed at addressing the twin epidemic of metabolic and cardiovascular disease in settings where more extended testing such as insulin assays are not feasible.…”
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    Online Artículo Texto
    Waist-to-height ratio and metabolic phenotype compared to the Matsuda index for the prediction of insulin resistance
  5. 132685
    “…While repurposing the existing FDA-approved drugs remains in the front line, exploring drug candidates from synthetic and natural compounds is also a viable alternative. …”
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    Identification of a novel inhibitor of SARS-CoV-2 3CL-PRO through virtual screening and molecular dynamics simulation
  6. 132686
    “…CONCLUSIONS: Fermented foods comprise a heterogeneous group of foods. While many of the candidate FIBs identified were found to be non-specific, greater specificity may be observed when considering a combination of compounds identified for individual fermented foods, food groups, and from fermentation processes. …”
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    A systematic review to identify biomarkers of intake for fermented food products
  7. 132687
    “…METHODS: A multistep process combining tools from user-centered design, A/B testing, and implementation science was used to understand, ideate, prototype, test, analyze, and improve each candidate CDS. CDS engagement metrics (alert views, acceptance rates) were used to evaluate which CDS version is superior. …”
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    Applying A/B Testing to Clinical Decision Support: Rapid Randomized Controlled Trials
  8. 132688
    “…These findings demonstrate that the HITSS assay, with only minor modifications, allows comparison screening of candidate compounds as potential attractants for anemotactic responses under laboratory-controlled conditions. …”
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    Dose–Response Assay for Synthetic Mosquito (Diptera: Culicidae) Attractant Using a High-Throughput Screening System
  9. 132689
    “…Our findings indicate that [(18)F]AlF-NOTA-NSC-GLU may be a potential candidate for HCC imaging. Also, a further biological evaluation is underway.…”
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    Biological Evaluation of [(18)F]AlF-NOTA-NSC-GLU as a Positron Emission Tomography Tracer for Hepatocellular Carcinoma
  10. 132690
    “…Researchers have looked for rapidly- and objectively-measurable electrophysiology biomarkers that accurately localize the epileptogenic zone. Promising candidates include interictal high-frequency oscillation and phase-amplitude coupling. …”
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    Objective interictal electrophysiology biomarkers optimize prediction of epilepsy surgery outcome
  11. 132691
    “…Due to complicated hospital course, and decreased functional status patient was not a candidate for chemotherapy immediately post hospital discharge.…”
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    Tissue Is the Issue - A Case of Malignant Insulinoma
  12. 132692
    “…Introduction: Ectopic ACTH secretion (EAS) causes myriad metabolic derangements which may be effectively managed with laparoscopic bilateral adrenalectomy (LBA) in fit-for-surgery candidates. Clinical Case: A 67-year old woman with a remote 12-pack year smoking history presented with unintentional weight loss, cough, fever and chest pain. …”
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    Laparoscopic Bilateral Adrenalectomy Should Be an Early Consideration in Ectopic Adrenocorticopic Hormone Secretion
  13. 132693
    “…However, hepatotoxicity occurred and thus it was discontinued with rapid rise of cortisol. As she was not a candidate for bilateral adrenalectomy, we started metyrapone with lowering of cortisol levels within 4 doses. …”
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    Development of Delayed Paraneoplastic ACTH Syndrome in Small Cell Lung Carcinoma
  14. 132694
    “…Pharmacological management can be considered in patients who are not surgical candidates, but is not always successful as was observed in this patient. …”
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    Paraneoplastic Hypoglycemia Leading to Insulin Independence in a Patient With Type 1 Diabetes
  15. 132695
    “…The patient was deemed a poor surgical candidate due to her history of multiple prior abdominal surgeries and a BMI of 46. …”
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    Cushing’s Syndrome Associated With an Adrenal Cavernous Hemangioma
  16. 132696
    por Rowell, Jennifer Voigt
    Publicado 2021
    “…He was deemed a non-surgical candidate. He was started on mifepristone 300 mg/day and spironolactone 12.5 mg/day given eGFR 47 mL/min/1.73sq m. …”
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    The Development of Hypogonadotropic Hypogonadism After Starting Low Dose Mifepristone for Cushing’s Syndrome
  17. 132697
    “…The MCODE plugin revealed two clusters, the former with 14 nodes, 73 edges, and a score of 9.733, and the latter with 6 nodes, 14 edges, and a score of 4.000. 9 candidate genes: ELANE, DEFA4, BPI, MPO, LTF, CAMP, OLFM4, LCN2, and VCL were identified, amongst which ELANE, LCN2, and MPO are associated with T2DM pathogenesis, while BPI and LTF have protective effects. …”
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    In-Silico Analysis of Key Regulatory Pathways and Hub Genes From Peripheral Blood in Type 2 Diabetes Mellitus
  18. 132698
    “…Our results showed that the S-trimer and RBD are both candidates for subunit vaccines in Betacoronavirus (SARS-CoV and SARS-CoV-2) with an RBD standing state. …”
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    Insight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike Proteins
  19. 132699
    “…In conclusion, Amodiaquine and Lumefantrine may be good antimalarial drug candidates for repurposing against HEV. Further in vitro and in vivo experiments are necessary to validate these predictions. …”
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    In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus
  20. 132700
    “…According topological analysis, six lncRNAs (NONRATT019236.2, NONRATT009530.2, NONRATT026999.2, TCONS_00032391, NONRATT023112.2, and NONRATT021956.2) were selected to establish the ceRNA-pathway network, and then two candidate hub lncRNAs (NONRATT009530.2 and NONRATT026999.2) were identified. …”
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    Bioinformatics-Based Analysis of the lncRNA-miRNA-mRNA Network and TF Regulatory Network to Explore the Regulation Mechanism in Spinal Cord Ischemia/Reperfusion Injury
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