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  1. 132801
    “…In this single-blinded randomized clinical trial, the patients who were candidates for laparoscopic cholecystectomy were randomly divided into the two groups (n = 38 per group). …”
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    A Comparison of effect of preemptive versus postoperative use of ultrasound-guided bilateral transversus abdominis plane (TAP) block on pain relief after laparoscopic cholecystectomy
  2. 132802
    “…Studies including comparator (HF [hydrofluoric acid] + silane + bonding) were candidates for meta-analysis. ARI scores were dichotomized. …”
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    Effects of Novel versus Conventional Porcelain Surface Treatments on Shear Bond Strength of Orthodontic Brackets: A Systematic Review and Meta-Analysis
  3. 132803
    “…METHODS: By screening a library of 52 Food and Drug Administration approved kinase inhibitors for their impact on T cell proliferation and cytokine release after CD3 stimulation, we identified mTOR, JAK and Src kinases inhibitors as potential candidates to modulate TCB-mediated cytokine release at pharmacologically active doses. …”
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    JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy
  4. 132804
    “…OBJECTIVE: To investigate the clinical significance of differentially expressed circRNAs and candidate circRNAs in the transformation of oral leukoplakia (OLK) to oral squamous cell carcinoma (OSCC). …”
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    Hsa_circ_0060927 Is a Novel Tumor Biomarker by Sponging miR-195-5p in the Malignant Transformation of OLK to OSCC
  5. 132805
    “…We evaluated associations of selected candidate polymorphisms in genes in these pathways, and interactions with pre-diagnostic serum antioxidants, and the risk of prostate cancer among 1,598 cases and 1,706 frequency-matched controls enrolled in the PCPT. …”
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    Associations Between Polymorphisms in Genes Related to Oxidative Stress and DNA Repair, Interactions With Serum Antioxidants, and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial
  6. 132806
    “…Finally, ITGAL [univariate hazard ratio (HR) =0.80, 95% confidence interval (CI): 0.69–0.93, P<0.01; multivariate HR =0.59, 95% CI: 0.40–0.86, P=0.01] and KLRB1 (univariate HR =0.78, 95% CI: 0.69–0.89, P<0.01; multivariate HR =0.72, 95% CI: 0.58–0.90, P<0.01) were correlated with the T-cell receptor signaling pathway and anaplastic lymphoma kinase (ALK) fusion (ITGAL: P=0.034; KLRB1: P=0.050), and were considered as candidate biomarkers. A significant relation between KLRB1 expression level and TMB (P=3.6e−05) was identified, while no relation was detected for ITGAL (P=0.11). …”
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    Systemic immune microenvironment and regulatory network analysis in patients with lung adenocarcinoma
  7. 132807
    “…Our findings contribute to further understanding the pathogenesis of GBM and finding possible candidate genes for prognostic and therapeutic usage with GBM.…”
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    Systematic analysis of the long noncoding RNA (lncRNA)-miRNA-mRNA competing endogenous RNA network to identify prognostic biomarkers and the potential regulatory axis in glioblastoma multiforme
  8. 132808
    “…Microarray experiments were conducted to identify differentially expressed genes (DEGs) by applying appropriate biostatistics to normalize and analyze the dataset. The candidate gene (IL27RA) was validated by quantitative reverse transcriptase-PCR (qRT-PCR) and immunohistochemistry (IHC). …”
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    IL-27/IL-27RA signaling may modulate inflammation and progression of benign prostatic hyperplasia via suppressing the LPS/TLR4 pathway
  9. 132809
    por Imai, Yuta, Kanie, Kei, Kato, Ryuji
    Publicado 2022
    “…Although donor selection is a critical early process that can maximize the production yield, determining the promising candidate is challenging owing to the lack of effective biomarkers and variations of cell sources. …”
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    Morphological heterogeneity description enabled early and parallel non-invasive prediction of T-cell proliferation inhibitory potency and growth rate for facilitating donor selection of human mesenchymal stem cells
  10. 132810
    “…Emerging research in remote memory clinics has highlighted computerized cognitive tests, such as the Integrated Cognitive Assessment (ICA), as prominent candidates for adoption in clinical practice both during the pandemic and for post-COVID-19 implementation as part of health care innovation. …”
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    The Use of a Computerized Cognitive Assessment to Improve the Efficiency of Primary Care Referrals to Memory Services: Protocol for the Accelerating Dementia Pathway Technologies (ADePT) Study
  11. 132811
    “…A cross-trait meta-analysis was used to identify novel candidate loci. Finally, potential causality of migraine susceptibility on stroke and CeAD was assessed by Mendelian randomization. …”
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    Migraine, Stroke, and Cervical Arterial Dissection: Shared Genetics for a Triad of Brain Disorders With Vascular Involvement
  12. 132812
    “…Herein, we identified the RAS-related protein 1b (Rap1b) as a potential HEV-ORF2 protein interacting candidate. Experimental infection of chickens and cells with an avian HEV isolate from China (CaHEV) led to upregulated expression and activation of Rap1b both in vivo and in vitro. …”
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    Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization
  13. 132813
    por Blandino, Alice, Scherer, Dominique, Rounge, Trine B., Umu, Sinan U., Boekstegers, Felix, Barahona Ponce, Carol, Marcelain, Katherine, Gárate-Calderón, Valentina, Waldenberger, Melanie, Morales, Erik, Rojas, Armando, Munoz, César, Retamales, Javier, de Toro, Gonzalo, Barajas, Olga, Rivera, María Teresa, Cortés, Analía, Loader, Denisse, Saavedra, Javiera, Gutiérrez, Lorena, Ortega, Alejandro, Bertrán, Maria Enriqueta, Gabler, Fernando, Campos, Mónica, Alvarado, Juan, Moisán, Fabrizio, Spencer, Loreto, Nervi, Bruno, Carvajal-Hausdorf, Daniel E., Losada, Héctor, Almau, Mauricio, Fernández, Plinio, Gallegos, Ivan, Olloquequi, Jordi, Fuentes-Guajardo, Macarena, Gonzalez-Jose, Rolando, Bortolini, Maria Cátira, Gallo, Carla, Linares, Andres Ruiz, Rothhammer, Francisco, Lorenzo Bermejo, Justo
    Publicado 2022
    “…ABSTRACT: Long noncoding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. …”
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    Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression
  14. 132814
    “…CONCLUSION: Rv1733c SLP, combined with ESAT-6 and CFP-10, might be used as a candidate antigen for T cell-based tuberculosis diagnostic tests to differentiate ATB from LTBI.…”
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    Mycobacterium tuberculosis latency-associated antigen Rv1733c SLP improves the accuracy of differential diagnosis of active tuberculosis and latent tuberculosis infection
  15. 132815
    por Shelton, J, McCall, M, Strickland, M
    Publicado 2022
    “…Many patients present with advanced-stage disease and only 10% of patients are candidates for surgical resection. Early research has shown there is an increased incidence of gallbladder cancer among patients with gallstone ileus. …”
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    A216 WHEN CANCER CASTS THE FIRST STONE: A CASE REPORT OF GALLBLADDER CANCER PRESENTING AS GALLSTONE ILEUS
  16. 132816
    “…An alternative hypothesis that ATP-dependent Pfk activity circumvents a need for PP(i) altogether was falsified by enzyme assays, heterologous expression of candidate genes, and whole-genome sequencing. As a secondary outcome, enzymatic assays confirmed functional annotation of clo1313_1832 as ATP- and GTP-dependent fructokinase. …”
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    Functional Analysis of H(+)-Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum
  17. 132817
    “…The lack of a high throughput screening (HTS) platform for candidate drug screening means that no targeted COVID-19 treatments have been developed to date. …”
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    The spike-ACE2 binding assay: An in vitro platform for evaluating vaccination efficacy and for screening SARS-CoV-2 inhibitors and neutralizing antibodies
  18. 132818
    “…The inclusion of genotypes from American Angus sires heavily used in Brazil just marginally increased the GEBV accuracies for selection candidates.…”
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    Development of genomic predictions for Angus cattle in Brazil incorporating genotypes from related American sires
  19. 132819
    “…Given that the ability to form biofilm is related to the antibiotic resistance of P. aeruginosa, our results indicate potential candidates for biomarkers assisting in selection of the most effective treatment for P. aeruginosa infections. …”
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    Virulence Genes as Markers for Pseudomonas aeruginosa Biofilm Formation in Dogs and Cats
  20. 132820
    “…Our results demonstrate the potential of deep-sea D. abyssi MT1.1(T) to mitigate salt stress in tomato seedlings and as a candidate of eco-friendly bio-inoculants for sustainable agriculture.…”
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    Plant Beneficial Deep-Sea Actinobacterium, Dermacoccus abyssi MT1.1(T) Promote Growth of Tomato (Solanum lycopersicum) under Salinity Stress
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