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  1. 132821
    “…Therefore, we explored the expression pattern of four crucial genes, bmp4, dazl, nanos3 and sycp2, in Hu sheep testicular development, and investigated the potential efficiency of overexpression of the four candidate genes using the CRISPR/dcas9 system in Leydig cells. …”
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    Overexpression of bmp4, dazl, nanos3 and sycp2 in Hu Sheep Leydig Cells Using CRISPR/dcas9 System Promoted Male Germ Cell Related Gene Expression
  2. 132822
    “…Four readers judged the authenticity of each image and chose their first- and second-choice candidates for the true image. In addition, for the three models, structural similarities (SSIM) were evaluated and the peak signal to noise ratio (PSNR) was compared among the three methods. (4) Results: The mean accuracy for the selection of true images for all four readers for their first choice was 52.0% (312/600). …”
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    Lumbar Spine Computed Tomography to Magnetic Resonance Imaging Synthesis Using Generative Adversarial Network: Visual Turing Test
  3. 132823
    “…PT150 is therefore a strong candidate for further clinical development for the treatment of COVID-19 across variants of SARS-CoV-2.…”
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    A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection
  4. 132824
    “…IMPORTANCE: The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab. …”
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    Efficacy of HD201 vs Referent Trastuzumab in Patients With ERBB2-Positive Breast Cancer Treated in the Neoadjuvant Setting: A Multicenter Phase 3 Randomized Clinical Trial
  5. 132825
    “…Variables with a p-value of < 0.25 in bivariate were a candidate for multivariate and those variables with a p-value of <0.05 in multivariate binary logistic regression were considered as a statistically significant factor for knowledge and attitude of the HPV vaccine. …”
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    Knowledge and Attitude Towards Human Papillomavirus Vaccine and Associated Factors Among Mothers Who Have Eligible Daughters in Debre Markos Town, Northwest Ethiopia
  6. 132826
    “…The expression profiles of the candidate genes interleukin 12 receptor subunit beta 1 (IL-12RB1), cytotoxic T-lymphocyte associated protein 4 (CTLA4), and G protein-coupled receptor 25 (GPR25) were identified in the single-cell RNA sequence OSCC dataset from GSE103322. …”
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    IL-12RB1: a novel immune prognostic biomarker for oral squamous cell carcinoma and linked to PD-1/PD-L1 expression in the tumor immune microenvironment
  7. 132827
    “…Participants were offered the two-dose candidate EVD vaccine regimen VAC52150 (Ad26.ZEBOV, Modified Vaccinia Ankara (MVA)-BN-Filo), with the doses being given 56 days apart. …”
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    Protocol for a phase 3 trial to evaluate the effectiveness and safety of a heterologous, two-dose vaccine for Ebola virus disease in the Democratic Republic of the Congo
  8. 132828
    “…This platform represents a novel HCV vaccine candidate amenable to large-scale manufacture at low cost.…”
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    Virus-Like Particles Containing the E2 Core Domain of Hepatitis C Virus Generate Broadly Neutralizing Antibodies in Guinea Pigs
  9. 132829
    “…Covariates from binary logistic regression were a candidate for multivariate logistic regression at p-value ⩽ 0.25. …”
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    Nurses are leaving the nursing profession: A finding from the willingness of the nurses to stay in the nursing profession among nurses working in selected public hospitals of Wollega Zones, Oromia, Ethiopia
  10. 132830
    “…SIMPLE SUMMARY: Liver resection for colorectal liver metastases (CRLM) represents the best curative option; however, few patients are candidates for surgery. Microwave ablation (MWA) can be a valid alternative in selected patients. …”
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    Microwave Ablation for Colorectal Liver Metastases: A Systematic Review and Pooled Oncological Analyses
  11. 132831
    “…Mesothelin (MSLN) is a candidate immunotherapy target; it is overexpressed by ovarian tumors and contributes to malignant/invasive phenotypes, making tumor antigen loss disadvantageous. …”
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    Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy
  12. 132832
    “…Magnetite nanoparticles (Fe(3)O(4) NPs) are one of the potent candidates to inhibit fungal infection by improving plant growth parameters. …”
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    Antifungal Potential of Green Synthesized Magnetite Nanoparticles Black Coffee–Magnetite Nanoparticles Against Wilt Infection by Ameliorating Enzymatic Activity and Gene Expression in Solanum lycopersicum L.
  13. 132833
    “…Patients must have clinical stage II or III (T3-T4Nany) LARC with distal location (≤5 cm from the anal verge or for those who are candidates for abdominoperineal resection or intersphincteric resection). …”
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    Non-operative management after chemoradiotherapy plus consolidation or sandwich (induction with bevacizumab and consolidation) chemotherapy in patients with locally advanced rectal cancer: a multicentre, randomised phase II trial (NOMINATE trial)
  14. 132834
    “…It also provides the basis for candidates selecting for the intervention. Recent convergent evidence supports the value of network-based approach for understanding the relationship between dysfunctional neural activity and motor deficits after stroke. …”
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    Functional brain networks assessed with surface electroencephalography for predicting motor recovery in a neural guided intervention for chronic stroke
  15. 132835
    “…We believe that GABPB1-AS1 is expected to become a candidate prognostic biomarker or a potential therapeutic target.…”
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    Revealing key lncRNAs in cytogenetically normal acute myeloid leukemia by reconstruction of the lncRNA–miRNA–mRNA network
  16. 132836
    “…Local and regional candidates for mentors and leaders were identified using bibliometric findings. …”
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    59 Burns in Low- and Middle-income Countries: A Scientometric Analysis of Peer-reviewed Research
  17. 132837
    “…Enzymatic assays were applied for the top candidates from both in silico approaches to test their ability to inhibit SARS-CoV-2 M(pro). …”
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    In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library
  18. 132838
    “…Additional pituitary ex vivo studies on candidates identified by RNAseq showed that these transcripts were preferentially regulated by Gnrh and sex steroids, but not by growth factors, and that Gnrh/sex steroids were less effective when incubating pituitaries from maturing males. …”
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    Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies
  19. 132839
    “…The sentiment analysis results for the 20 key aspects revealed negative sentiments related to “vaccine distribution,” “side effects,” “allergy,” “reactions,” and “anti-vaxxer,” and positive sentiments related to “vaccine campaign,” “vaccine candidates,” and “immune response.” These results indicate that the Twitter users express concerns about the safety of vaccines but still consider vaccines as the option to end the pandemic. …”
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    Tracking Public Attitudes Toward COVID-19 Vaccination on Tweets in Canada: Using Aspect-Based Sentiment Analysis
  20. 132840
    “…BACKGROUND: Frail patients are considered at relevant risk of complications due to coronavirus disease 2019 (COVID-19) infection and, for this reason, are prioritized candidates for vaccination. As these patients were originally not included in the registration trials, fear related to vaccine adverse events and disease worsening was one of the reasons for vaccine hesitancy. …”
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    mRNA-COVID19 Vaccination Can Be Considered Safe and Tolerable for Frail Patients
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