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  1. 132861
    por Cihan, Pınar, Ozger, Zeynep Banu
    Publicado 2022
    “…As a result, 11 possible nonallergic, high antigen and nontoxic epitope candidates were proposed that could be used in protein-based COVID-19 vaccine design (“VGGNYNY”, “VNFNFNGLTG”, “RQIAPGQTGKI”, “QIAPGQTGKIA”, “SYECDIPIGAGI”, “STFKCYGVSPTKL”, “GVVFLHVTYVPAQ”, “KNHTSPDVDLGDI”, “NHTSPDVDLGDIS”, “AGAAAYYVGYLQPR”, “KKSTNLVKNKCVNF”). …”
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    Online Artículo Texto
    A new approach for determining SARS-CoV-2 epitopes using machine learning-based in silico methods
  2. 132862
    “…Our study is the first to report a novel approach that uncovers the impact of BRV infection on the miRNA expressions of MA-104 cells, and it offers clues for identifying potential candidates for antiviral or vaccine strategies.…”
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    MicroRNA Profile of MA-104 Cell Line Associated With the Pathogenesis of Bovine Rotavirus Strain Circulated in Chinese Calves
  3. 132863
    “…HIGHLIGHTS: 1) Mature and juvenile specimens of J. maritimus, P. australis, and T. latifolia have high salinity tolerance in solid media spiked up to 24 ‰ NaCl. 2) Mature plants have generally better Cl(−) removal and phytoremediation performances than juvenile specimens. 3) J. maritimus is the most effective species for chloride phytoremediation with high survival and high Cl(−) sequestration in shoots. 4) T. latifolia has high Cl(−) removal in shoots and good remediation capacities but also shows sign of stress. 5) P. australis shows low Cl(−) sequestration and is a poor candidate for chloride remediation from substrate. …”
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    Chloride accumulation in aboveground biomass of three macrophytes (Phragmites australis, Juncus maritimus, and Typha latifolia) depending on their growth stages and salinity exposure: application for Cl(−) removal and phytodesalinization
  4. 132864
    “…Hence, compounds that attenuate neuroinflammation could become promising drug candidates for ischemic stroke. Fraxetin has an anti-inflammatory effect in many inflammatory diseases. …”
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    Fraxetin alleviates microglia-mediated neuroinflammation after ischemic stroke
  5. 132865
    “…To conclude, the pleiotropic anticancer activities of this novel chimeric HDAC- and tubulin inhibitor broxbam suggest that this compound is a promising candidate for liver cancer treatment, which warrants further pre-clinical and clinical evaluation.…”
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    Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer
  6. 132866
    “…CONCLUSIONS: The staff eHLQ may be a good candidate for monitoring the medical staff’s digital competence in and response to the implementation of new digital solutions. …”
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    Health Professionals’ eHealth Literacy and System Experience Before and 3 Months After the Implementation of an Electronic Health Record System: Longitudinal Study
  7. 132867
    “…The FIB‐4 provides a simple tool to prioritize candidates for third‐dose vaccine booster.…”
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    Advanced Liver Fibrosis Correlates With Impaired Efficacy of Pfizer‐BioNTech COVID‐19 Vaccine in Medical Employees
  8. 132868
    “…A series of analyses of common host factors for COVID-19 and asthma were conducted, including PPI network construction, module analysis, enrichment analysis, inference of the upstream pathway activity of host factors, tissue-specific analysis and drug candidate prediction. Finally, the key host factors were verified in the GSE152418 and GSE164805 datasets. …”
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    Insights into potential mechanisms of asthma patients with COVID-19: A study based on the gene expression profiling of bronchoalveolar lavage fluid
  9. 132869
    “…These findings suggest that non-invasive functional connectivity may be a candidate personalized biomarker that has the potential to predict responsive neurostimulation effectiveness and to identify patients most likely to benefit from responsive neurostimulation therapy. …”
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    Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy
  10. 132870
    “…METHODS: Between June 1, 2016, and May 31, 2018, 3019 consecutive adult patients (aged ≥16 years) undergoing cardiac magnetic resonance (CMR) at Manchester University National Health Service Foundation Trust, Manchester, UK, were prospectively recruited into a model development cohort. Candidate predictor variables were selected according to clinical practice and literature review. …”
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    Predicting hospitalisation for heart failure and death in patients with, or at risk of, heart failure before first hospitalisation: a retrospective model development and external validation study
  11. 132871
    “…After data normalization, we used a two-step approach to identify candidate biomarkers associated to both objective response (OR) by RECIST and longer overall survival (OS). …”
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    Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients
  12. 132872
    “…This work illustrates the potential of using atomistic molecular dynamics (MD) and grand-canonical Monte Carlo (GCMC) simulations prior to experiments in order to pre-screen candidate membrane structures for gas separation, under harsh conditions of temperature and pressure. …”
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    Molecular Characterization of Membrane Gas Separation under Very High Temperatures and Pressure: Single- and Mixed-Gas CO(2)/CH(4) and CO(2)/N(2) Permselectivities in Hybrid Networks
  13. 132873
    “…AIM: To investigate the candidate genes and pathways involved in DCM patients. …”
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    Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy
  14. 132874
    “…Patients who were determined to be good candidates for shunts (N = 71, 31.7%) took another MoCA assessment following shunt insertion. …”
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    The Clinical Utility of the MOCA in iNPH Assessment
  15. 132875
    “…Therefore, STE could be a valuable approach to select candidates for catheter ablation.…”
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    Prediction of Left Atrial Fibrosis and Success of Catheter Ablation by Speckle Tracking Echocardiography in Patients Imaged in Persistent Atrial Fibrillation
  16. 132876
    “…High mRNA expression of CXCL8 was associated with better OS in patients with EBVaGC, while high expression of CXCL9 was associated with better OS in patients with EBVnGC. We obtained 10 candidate potential transcription factors (TFs) associated with CXCLs: OTOP3, NKX6-2, NKX2-2, FEV, SMYD1, TRIMSO, TBX10, CDX1, SLC26A3, and ARC. 576 miRNA-mRNA interactions were obtained. …”
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    Characterization of the Prognostic Values of CXCL Family in Epstein–Barr Virus Associated Gastric Cancer
  17. 132877
    “…IMPORTANCE: Current guidelines for primary implantable cardioverter-defibrillator (ICD) therapy do not account for sex differences in arrhythmic risk in ICD candidates. OBJECTIVE: To evaluate the association between sex and risk of ventricular tachyarrhythmia (VTA) and mortality. …”
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    Sex Differences in the Risk of First and Recurrent Ventricular Tachyarrhythmias Among Patients Receiving an Implantable Cardioverter-Defibrillator for Primary Prevention
  18. 132878
    “…To a certain extent, some non-invasive alien plants might adapt to metalliferous environments and serve as hyperaccumulator candidates in phytoremediation projects in contaminated environments.…”
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    Leaf Functional Traits of Invasive Grasses Conferring High-Cadmium Adaptation Over Natives
  19. 132879
    “…Therefore, the strain TDS9 could be a potential candidate for cellulase production in an industrial biotransformation process of paper mill sludge to produce reducing sugar. …”
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    Cellulase activity of a novel bacterial strain Arthrobacter woluwensis TDS9: its application on bioconversion of paper mill sludge
  20. 132880
    “…We also discovered differential expression of candidate proteins such as kinase VRK1 and collagen COL5A1 from proteomic profiling. …”
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    371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction
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