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132861“…As a result, 11 possible nonallergic, high antigen and nontoxic epitope candidates were proposed that could be used in protein-based COVID-19 vaccine design (“VGGNYNY”, “VNFNFNGLTG”, “RQIAPGQTGKI”, “QIAPGQTGKIA”, “SYECDIPIGAGI”, “STFKCYGVSPTKL”, “GVVFLHVTYVPAQ”, “KNHTSPDVDLGDI”, “NHTSPDVDLGDIS”, “AGAAAYYVGYLQPR”, “KKSTNLVKNKCVNF”). …”
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132862“…Our study is the first to report a novel approach that uncovers the impact of BRV infection on the miRNA expressions of MA-104 cells, and it offers clues for identifying potential candidates for antiviral or vaccine strategies.…”
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132863por Delattre, Emmanuel, Techer, Isabelle, Reneaud, Benjamin, Verdoux, Patrick, Laffont-Schwob, Isabelle, Prohin, Philippe“…HIGHLIGHTS: 1) Mature and juvenile specimens of J. maritimus, P. australis, and T. latifolia have high salinity tolerance in solid media spiked up to 24 ‰ NaCl. 2) Mature plants have generally better Cl(−) removal and phytoremediation performances than juvenile specimens. 3) J. maritimus is the most effective species for chloride phytoremediation with high survival and high Cl(−) sequestration in shoots. 4) T. latifolia has high Cl(−) removal in shoots and good remediation capacities but also shows sign of stress. 5) P. australis shows low Cl(−) sequestration and is a poor candidate for chloride remediation from substrate. …”
Publicado 2022
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132864por Deng, Shi-Ji, Ge, Jian-Wei, Xia, Sheng-Nan, Zou, Xin-Xin, Bao, Xin-Yu, Gu, Yue, Xu, Yun, Meng, Hai-Lan“…Hence, compounds that attenuate neuroinflammation could become promising drug candidates for ischemic stroke. Fraxetin has an anti-inflammatory effect in many inflammatory diseases. …”
Publicado 2022
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132865por Bär, Sofia Isolde, Dittmer, Alexandra, Nitzsche, Bianca, Ter-Avetisyan, Gohar, Fähling, Michael, Klefenz, Adrian, Kaps, Leonard, Biersack, Bernhard, Schobert, Rainer, Höpfner, Michael“…To conclude, the pleiotropic anticancer activities of this novel chimeric HDAC- and tubulin inhibitor broxbam suggest that this compound is a promising candidate for liver cancer treatment, which warrants further pre-clinical and clinical evaluation.…”
Publicado 2022
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132866por Kayser, Lars, Karnoe, Astrid, Duminski, Emily, Jakobsen, Svend, Terp, Rikke, Dansholm, Susanne, Roeder, Michael, From, Gustav“…CONCLUSIONS: The staff eHLQ may be a good candidate for monitoring the medical staff’s digital competence in and response to the implementation of new digital solutions. …”
Publicado 2022
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132867por Shafrir, Asher, Amer, Johnny, Hakimian, David, Milgrom, Yael, Massarwa, Muhammad, Hazou, Wadi, Imam, Ashraf, Khalaileh, Abed, Safadi, Rifaat“…The FIB‐4 provides a simple tool to prioritize candidates for third‐dose vaccine booster.…”
Publicado 2022
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132868por Jiang, Yong, Yan, Qian, Liu, Cheng-Xin, Peng, Chen-Wen, Zheng, Wen-Jiang, Zhuang, Hong-Fa, Huang, Hui-ting, Liu, Qiong, Liao, Hui-Li, Zhan, Shao-Feng, Liu, Xiao-Hong, Huang, Xiu-Fang“…A series of analyses of common host factors for COVID-19 and asthma were conducted, including PPI network construction, module analysis, enrichment analysis, inference of the upstream pathway activity of host factors, tissue-specific analysis and drug candidate prediction. Finally, the key host factors were verified in the GSE152418 and GSE164805 datasets. …”
Publicado 2022
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132869por Fan, Joline M., Lee, Anthony T., Kudo, Kiwamu, Ranasinghe, Kamalini G., Morise, Hirofumi, Findlay, Anne M., Kirsch, Heidi E., Chang, Edward F., Nagarajan, Srikantan S., Rao, Vikram R.“…These findings suggest that non-invasive functional connectivity may be a candidate personalized biomarker that has the potential to predict responsive neurostimulation effectiveness and to identify patients most likely to benefit from responsive neurostimulation therapy. …”
Publicado 2022
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132870por Bradley, Joshua, Schelbert, Erik B, Bonnett, Laura J, Lewis, Gavin A, Lagan, Jakub, Orsborne, Christopher, Brown, Pamela F, Naish, Josephine H, Williams, Simon G, McDonagh, Theresa, Schmitt, Matthias, Miller, Christopher A“…METHODS: Between June 1, 2016, and May 31, 2018, 3019 consecutive adult patients (aged ≥16 years) undergoing cardiac magnetic resonance (CMR) at Manchester University National Health Service Foundation Trust, Manchester, UK, were prospectively recruited into a model development cohort. Candidate predictor variables were selected according to clinical practice and literature review. …”
Publicado 2022
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132871por Pantano, Francesco, Zalfa, Francesca, Iuliani, Michele, Simonetti, Sonia, Manca, Paolo, Napolitano, Andrea, Tiberi, Simone, Russano, Marco, Citarella, Fabrizio, Foderaro, Simone, Vulpis, Elisabetta, Zingoni, Alessandra, Masuelli, Laura, Bei, Roberto, Ribelli, Giulia, Del Re, Marzia, Danesi, Romano, Vincenzi, Bruno, Perrone, Giuseppe, Tonini, Giuseppe, Santini, Daniele“…After data normalization, we used a two-step approach to identify candidate biomarkers associated to both objective response (OR) by RECIST and longer overall survival (OS). …”
Publicado 2022
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132872por Neyertz, Sylvie, Brown, David, Salimi, Saman, Radmanesh, Farzaneh, Benes, Nieck E.“…This work illustrates the potential of using atomistic molecular dynamics (MD) and grand-canonical Monte Carlo (GCMC) simulations prior to experiments in order to pre-screen candidate membrane structures for gas separation, under harsh conditions of temperature and pressure. …”
Publicado 2022
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132873por Liu, Zhou, Song, Ying-Nan, Chen, Kai-Yuan, Gao, Wei-Long, Chen, Hong-Jin, Liang, Gui-You“…AIM: To investigate the candidate genes and pathways involved in DCM patients. …”
Publicado 2022
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132874por Wesner, Eric, Etzkorn, Lacey, Bakre, Shivani, Chen, Jinyu, Davis, Alexander, Zhang, Yifan, Yasar, Sevil, Rao, Aruna, Luciano, Mark, Wang, Jiangxia, Moghekar, Abhay“…Patients who were determined to be good candidates for shunts (N = 71, 31.7%) took another MoCA assessment following shunt insertion. …”
Publicado 2022
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132875por Marchandise, Sébastien, Garnir, Quentin, Scavée, Christophe, Varnavas, Varnavas, le Polain de Waroux, Jean-Benoit, Wauters, Aurélien, Beauloye, Christophe, Roelants, Véronique, Gerber, Bernhard L.“…Therefore, STE could be a valuable approach to select candidates for catheter ablation.…”
Publicado 2022
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132876“…High mRNA expression of CXCL8 was associated with better OS in patients with EBVaGC, while high expression of CXCL9 was associated with better OS in patients with EBVnGC. We obtained 10 candidate potential transcription factors (TFs) associated with CXCLs: OTOP3, NKX6-2, NKX2-2, FEV, SMYD1, TRIMSO, TBX10, CDX1, SLC26A3, and ARC. 576 miRNA-mRNA interactions were obtained. …”
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132877por Saxena, Shireen, Goldenberg, Ilan, McNitt, Scott, Hsich, Eileen, Kutyifa, Valentina, Bragazzi, Nicola Luigi, Polonsky, Bronislava, Aktas, Mehmet K., Huang, David T., Rosero, Spencer, Klein, Helmut, Zareba, Wojciech, Younis, Arwa“…IMPORTANCE: Current guidelines for primary implantable cardioverter-defibrillator (ICD) therapy do not account for sex differences in arrhythmic risk in ICD candidates. OBJECTIVE: To evaluate the association between sex and risk of ventricular tachyarrhythmia (VTA) and mortality. …”
Publicado 2022
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132878por Ilyas, Muhammad, Shah, Sakhawat, Lai, Ya-Wen, Sher, Jan, Bai, Tao, Zaman, Fawad, Bibi, Farkhanda, Koul, Monika, Wani, Shabir Hussain, Majrashi, Ali, Alharby, Hesham F., Hakeem, Khalid Rehman, Wang, Yong-Jian, Rather, Shabir A.“…To a certain extent, some non-invasive alien plants might adapt to metalliferous environments and serve as hyperaccumulator candidates in phytoremediation projects in contaminated environments.…”
Publicado 2022
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132879“…Therefore, the strain TDS9 could be a potential candidate for cellulase production in an industrial biotransformation process of paper mill sludge to produce reducing sugar. …”
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132880por Samudrala, Sai Suma, Anfinson, Melissa, Cavanaugh, Matthew, Kim, Min-Su, Lamberton, Peter, Radandt, Jackson, Brown, Ryan, Liang, Huan Ling, Stamm, Karl, Zeeshan, Afzal, Strande, Jennifer, Frommelt, Michele, Lough, John W., Fitts, Robert, Mitchell, Michael E., Tomita-Mitchel, Aoy“…We also discovered differential expression of candidate proteins such as kinase VRK1 and collagen COL5A1 from proteomic profiling. …”
Publicado 2022
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