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132881por Jiang, Yong, Xie, Yi-Zi, Peng, Chen-Wen, Yao, Kai-Nan, Lin, Xue-Ying, Zhan, Shao-Feng, Zhuang, Hong-Fa, Huang, Hui-Ting, Liu, Xiao-Hong, Huang, Xiu-Fang, Li, Hang“…Conclusion: Kaempferol is a candidate treatment for COVID-19/PF co-occurrence. …”
Publicado 2022
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132882por Marastoni, Damiano, Pisani, Anna I., Schiavi, Gianmarco, Mazziotti, Valentina, Castellaro, Marco, Tamanti, Agnese, Bosello, Francesca, Crescenzo, Francesco, Ricciardi, Giuseppe K., Montemezzi, Stefania, Pizzini, Francesca B., Calabrese, Massimiliano“…CSF TNF levels are a possible candidate in predicting treatment response, in addition to clinical, demographic and MRI variables.…”
Publicado 2022
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132883por Liu, Tong, Tang, Jing, Li, Xiaoyu, Lin, Yuan, Yang, Yuma, Ma, Kai, Hui, Zhaoyuan, Ma, Hong, Qin, Yanyan, Lei, Hetian, Yang, Yanhui“…The CRISPR/Cas9 system was used to knock out HIF1A in HepG2 cells, and RNA sequencing was utilized to characterize differentially expressed mRNAs and miRNAs in the HIF1A-knockout HepG2 cells; the identified candidates were then analyzed by GO annotation and KEGG pathway enrichment to study their function and establish a PPI network. …”
Publicado 2022
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132884por Parcha, Vibhu, Irvin, Marguerite R., Lange, Leslie A., Armstrong, Nicole D., Pampana, Akhil, Meyer, Mariah, Judd, Suzanne E., Arora, Garima, Arora, Pankaj“…CONCLUSIONS: Corin gene variants observed more commonly in Black individuals are not associated with differences in NP expression, circulating NP levels, and BP or hypertension as previously reported in candidate gene studies. Understanding the genetic determinants of complex cardiovascular traits in underrepresented populations requires further evaluation.…”
Publicado 2022
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132885“…To broaden the antigen repertoire and robustness of rLm30, we constructed 16 recombinant attenuated L. monocytogenes vaccine candidates expressing 3, 4, or 5 among 15 selected M. tuberculosis antigens, verified their protein expression, genetic stability, and growth kinetics in macrophages, and evaluated them for capacity to boost protective efficacy in BCG-primed mice. …”
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132886por Saleh, Ahmed A., Rashad, Amr M. A., Hassanine, Nada. N. A. M., Sharaby, Mahmoud A., Zhao, Yongju“…FGF-5 gene was detected as a candidate gene for hair and cashmere traits in IMCG breed. …”
Publicado 2022
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132887por Larkins, Nicholas G., D’Orsogna, Lloyd, Taverniti, Anne, Sharma, Ankit, Chakera, Aron, Chan, Doris, Krishnan, Anoushka, Wong, Germaine, Lim, Wai H.“…The inaccurate assignment of DSA from donor LD-typing may result in associated HLA being considered unacceptable mismatches, inappropriately precluding candidates’ access to transplantation. Accurate imputation of two-field HLA alleles based on LD from SSO and rtPCR HLA typing remains a substantial challenge in clinical practice in-lieu of widely available, rapid, high-resolution methods.…”
Publicado 2022
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132888por Hohl, Corinne M., Rosychuk, Rhonda J., Archambault, Patrick M., O’Sullivan, Fiona, Leeies, Murdoch, Mercier, Éric, Clark, Gregory, Innes, Grant D., Brooks, Steven C., Hayward, Jake, Ho, Vi, Jelic, Tomislav, Welsford, Michelle, Sivilotti, Marco L.A., Morrison, Laurie J., Perry, Jeffrey J.“…We randomly assigned hospitals to derivation or validation, and prespecified clinical variables as candidate predictors. We used logistic regression to develop the score in a derivation cohort and examined its performance in predicting emergency department and in-hospital mortality in a validation cohort. …”
Publicado 2022
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132889por Sun, Yize, Wang, Zheyi, Hou, Jiqiu, Shi, Jinyu, Tang, Zhuoran, Wang, Chao, Zhao, Haibin“…Macrophage/microglia inflammation mediated by S100A9 is considered a pivotal pathogenic in depression after AMI and a major pathway for the treatment of PCF, suggesting that PCF is a promising therapeutic candidate for psycho-cardiology disease.…”
Publicado 2022
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132890por Peng, Liying, Bai, Ge, Wang, Chunzheng, Dong, Jianan, Liu, Yongjun, Sun, Zhe, Zhen, Yuguo, Qin, Guixin, Zhang, Xuefeng, Demelash, Natnael, Wang, Tao“…The mRNA levels of SCD1 and candidate genes were analyzed via real-time PCR. Tandem mass tag (TMT)-based quantitative proteomics, bioinformatic analysis, parallel reaction monitoring (PRM), and small RNA interference were used to explore genes involved in the SCD1-dependent c9, t11-CLA biosynthesis. …”
Publicado 2022
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132891por Li, Yuekun, Li, Li, Liu, Fangyan, Wang, Biao, Gao, Feng, Liu, Chuan, Fang, Jingyun, Huang, Feng, Lin, Zhang, Wang, Mengye“…This facile yet robust piezocatalytic route using minimal amounts of catalysts to obtain H(2)O(2) and H(2) may stand out as a promising candidate for environmental applications and water splitting. …”
Publicado 2022
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132892por Zhang, Shan-Qiang, Pan, Su-Ming, Lai, Shu-Zhen, Situ, Hui-Jing, Liu, Jun, Dai, Wen-Jie, Liang, Si-Xian, Zhou, Li-Qing, Lu, Qi-Qi, Ke, Pei-Feng, Zhang, Fan, Chen, Hai-Bin, Li, Ji-Cheng“…The area under the receiver operating characteristic curve (AUC) was used to evaluate the performance of candidate biomarkers in predicting IC beneficiaries. …”
Publicado 2022
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132893“…In the era of virtual interviewing from the same potential pool of applicants, programs should review and revise their web presence with the aim to increase the availability of online content to attract valuable candidates.…”
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132894“…Tau pathology, neuroinflammation, and neurodegeneration are the leading candidate predictors. We aimed to determine these three aspects of biomarkers in cerebrospinal fluid (CSF) and plasma to predict longitudinal cognition status using Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. …”
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132895“…CONCLUSIONS: ADAMTSL4, COL6A1, CTSL, CYTH4, EGFLAM, LILRB2, MPZL2, SAA2, and LSP1 are the candidate tumor antigens for mRNA vaccine development in GBM, and IS1 GBM patients are best suited for mRNA vaccination, IS2 patients are best suited for immune checkpoint inhibitor. …”
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132896por Grijalva, Alicia, Gallo Vaulet, Lucia, Agüero, Roberto Nicolas, Toledano, Analia, Risso, Marikena Guadalupe, Quarroz Braghini, Juan, Sosa, David, Ruybal, Paula, Repetto, Silvia, Alba Soto, Catalina Dirney“…CONCLUSION: The genotype TT at -819 rs1800871 contributes to the genetic susceptibility to CCC making this polymorphism a suitable candidate to be included in a panel of predictive biomarkers of disease progression.…”
Publicado 2022
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132897por Wang, Xi, Zhang, Cheng-Sheng, Dong, Xu-Yuan, Hu, Yuan, Duan, Bao-Jun, Bai, Jun, Wu, Yin-Ying, Fan, Lin, Liao, Xin-Hua, Kang, Ye, Zhang, Peng, Li, Meng-Yang, Xu, Jiao, Mao, Zhi-Jun, Liu, Hui-Tong, Zhang, Xiao-Long, Tian, Li-Fei, Li, En-Xiao“…Recent studies have regarded tight junction protein claudin 18.2 (CLDN18.2) as a candidate target for cancer treatment, and zolbetuximab (formerly known as IMAB362) has been developed against CLDN18.2. …”
Publicado 2022
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132898“…These findings suggest that Heliotropium ramosissimum contains potent therapeutic candidates for colorectal cancer treatment.…”
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132899por Pan, Xiaojuan, Huang, Bo, Ma, Qiang, Ren, Junwu, Liu, Yuying, Wang, Cong, Zhang, Dawei, Fu, Jian, Ran, Lingyu, Yu, Ting, Li, Haiping, Wang, Xiaolin, Yang, Feifei, Liang, Ce, Zhang, Yuying, Wang, Shimin, Ren, Jingjing, Li, Wei, Wang, Yongquan, Xiao, Bin“…METHODS: The circRNAs microarray (n = 4) was performed to investigate the circRNAs with differential expression in ccRCC tissues. The candidate circRNA was selected based on the cut‐off criteria, such as circRNA expression abundance, circRNA size and the design of divergent primers. …”
Publicado 2022
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132900por Mo, Jiayuan, Lu, Yujie, Jiang, Shan, Yan, Gang, Xing, Tianqi, Xu, Di, He, Yaoyin, Xie, Bingkun, Lan, Ganqiu, Chen, Baojian, Liang, Jing“…SIMPLE SUMMARY: Lactobacillus delbrueckii subsp. bulgaricus (LDB) is an important candidate for antibiotic replacement in pig production. …”
Publicado 2022
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