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  1. 132961
    “…Certainly, in cases where patients are candidates for a TMA, the decision might seem rather straightforward. …”
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    Transmetatarsal Amputation Results in Higher Frequency of Revision Surgery and Higher Ambulation Rates Than Below- Knee Amputation
  2. 132962
    “…This may be especially relevant in surgical candidates in whom osteotomies such as a scarf are being considered, where pronation cannot be addressed.…”
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    Plain Radiographs are Insufficient for Evaluation of First Metatarsal Pronation in Patients Undergoing Surgery for Hallux Valgus
  3. 132963
    “…Using an integrative analysis, we selected pseudouridine synthase1(PUS1) as the candidate biomarker. A tissue microarray of 131 breast cancer patients was then utilized to determine the clinical significance and prognostic value of PUS1. …”
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    PUS1 is a novel biomarker for predicting poor outcomes and triple-negative status in breast cancer
  4. 132964
    “…CONCLUSION: Our results recognize LHA-CRHr1 as a capable candidate that modulates acute stress-induced anxiety development and chronic stress-induced changes in the cellular population of the region. …”
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    Lateral Hypothalamus Corticotropin-releasing Hormone Receptor-1 Inhibition and Modulating Stress-induced Anxiety Behavior
  5. 132965
    “…The cells H295R-CYP11B2 N-Luc were stimulated with KCl to cause depolarization, after which candidate compounds were added and HTS was performed by Luc assay. …”
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    LBODP025 A Novel Drug Discovery For Primary Aldosteronism Targeting Aldosterone Synthase (cyp11b2) And Kcnj5 Mutant
  6. 132966
    “…METHODS AND RESULTS: Candidate items were selected based on psychometric properties and symptom range coverage. …”
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    The development and initial validation of the PROMIS®+HF‐27 and PROMIS+HF‐10 profiles
  7. 132967
    “…Induced pluripotent stem cell (iPSC)-based drug repurposing identified the Src/c-Abl inhibitor bosutinib, which is approved for the treatment of chronic myelogenous leukemia (CML), as a candidate for the molecular targeted therapy of ALS. …”
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    Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial
  8. 132968
    “…The results were compared with motor cortex dysregulated transcripts obtained from 11patients with sporadic ALS and 8 HCs. Candidate proteins were tested using ELISA in the serum of 123 patients with ALS, 30 patients with Alzheimer disease (AD), 28 patients with frontotemporal dementia (FTD), and 102 HCs. …”
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    Neuroinflammation-Related Proteins NOD2 and Spp1 Are Abnormally Upregulated in Amyotrophic Lateral Sclerosis
  9. 132969
    “…Next, we generated and screened six unique mAbs that specifically target human CD103 positive cells. Optimal candidates were selected for (89)Zr-anti-human CD103 PET development. …”
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    Development of (89)Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
  10. 132970
    “…We validated the direct regulated targets of two of these candidate NUEg TFs in a plant cell-based TF assay called TARGET, for which we also had in planta data for comparison. …”
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    Validation of a high-confidence regulatory network for gene-to-NUE phenotype in field-grown rice
  11. 132971
    “…This article focuses mainly on the decision-making process which determines the ideal candidates for on-table extubation and the anesthetic protocol implemented in a low-resource environment to enable the same.…”
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    One-Year Experience after Adoption of an On-Table Extubation Protocol Following Pediatric Cardiac Surgery
  12. 132972
    “…Interestingly, specific hotspot mutations have been identified as potential candidates for novel targeted therapies in several malignancies as per G12C. …”
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    Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer
  13. 132973
    “…The primary objective of our study was to investigate novel CSF protein candidates and replicate previously reported protein biomarker changes in CSF from Huntington disease mutation carriers and healthy controls. …”
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    Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity
  14. 132974
    “…These results suggest that DDK-401 could act as a molecular switch for these two cellular processes in response to cell damage signaling and that it could be a potential candidate for further evaluations in health promotion studies.…”
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    Transcriptome expression profile of compound-K-enriched red ginseng extract (DDK-401) in Korean volunteers and its apoptotic properties
  15. 132975
    “…Clinically improving patients without persistent BSI and a controlled source of infection are candidates for oral antimicrobial therapy (OAT) but despite anecdotal practice, there are few studies affirming the practice of OAT for gram-positive uBSI. …”
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    1846. Outcomes in Intravenous to Oral Antimicrobial Therapy in Beta-Streptococcus Species
  16. 132976
    “…Tweets or tweet segments with flavor keywords but not any known flavor names were marked as potential new flavor candidates, which were further verified by a web-based search. …”
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    Monitoring and Identifying Emerging e-Cigarette Brands and Flavors on Twitter: Observational Study
  17. 132977
    “…These results may help develop the next generation of vaccine candidates for HIV-1.…”
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    Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals
  18. 132978
    “…Therefore, Th2 cytokines are considered to be candidate therapeutic targets. OBJECTIVE: To evaluate the clinical responses of patients with Netherton syndrome to dupilumab, an IL-4Rα antagonist, and identify changes in the Th1/2/17 pathway activity, skin barrier defect protein LEKTI expression after treatment. …”
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    Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation
  19. 132979
    “…Furthermore, ZnO is less toxic and cheaper, making it a suitable candidate for drug delivery, bioimaging, wound healing, antimicrobial applications, and cancer treatment. …”
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    In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles
  20. 132980
    por Sun, Jingyi, Chen, Weihao, Yuan, Zehu
    Publicado 2022
    “…After the challenge experiment, healthy lambs in the high-dose challenge group and severely diarrheic lamb in the low-dose challenge group were identified as lambs sensitive/resistant to E. coli F17 (E. coli F17 -resistant/-sensitive candidate, AN/SE) according to the histopathological detection. …”
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    Characterization of Intestinal Microbiota in Lambs with Different Susceptibility to Escherichia coli F17
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