“…Our review can help advancing this research area, as it makes the 20 species with male-male courtship display for which the intrasexual competition hypothesis was suggested excellent candidates for empirical research.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Combined microfracture and arthroscopic labral repair produced modest, albeit statistically significant, improvements in patient-reported outcome measures and may be a reasonable treatment option for patients with chondral lesions who are not candidates for arthroplasty. However, microfracture patients had significantly worse outcomes than patients who underwent stabilization without concomitant chondral defects.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The effect of GSG on NASH rats was evaluated by pathological staining and analysis of various index results. Finally, the candidate targets were further validated by ELISA and western blot (WB) analyses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further collaborations are required to develop criteria to identify ideal pediatric candidates and optimally time interventions in order to maximize the benefits of this treatment.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our previous studies have identified three mRNA transcripts related to innate immune activation: alkaline phosphatase (ALPL), interleukin-8 receptor-β (IL8RB), and defensin-1 (DEFA1) as promising candidates to detect an intra-abdominal infection. The objective of this study was to evaluate the accuracy of these mRNA biomarkers to predict likely infection, hospitalization and surgery in Emergency Department patients with undifferentiated abdominal pain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then, we modeled the coculture of NMIBC organoids with candidate urinary Eubacterium sp. CAG:581 in anaerobic conditions and explored differentially expressed genes of these NMIBC tissues by RNA-Seq. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As a result of mTOR phosphorylation, a suppression in autophagy and actin remodeling follows. Our candidate tumor suppressor p38 as well as its downstream targets such as phosphorylation of mTOR, actin remodeling and autophagy can be modulated with pharmacologically available small molecules such as anisomycin, rapamycin, hydroxychloroquine and cytochalasin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Due to the severity of the increased risk, it becomes very important to develop novel drug candidates from natural sources and evaluate various preventive measures against cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most promising miRNA biomarker candidates were validated by droplet digital polymerase chain reaction in a validation cohort of 115 rats (8 naïve, 17 sham, and 90 TBI rats [21 with epilepsy]). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Many of the affected patients are elderly with comorbidities who are not candidates for standard-of-care curative-intent treatment with surgery and/or radio-/chemotherapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To uncover the molecular mechanism underlying the rSG10-F23A budding deficiency, the bridging proteins between the FPIV L-domain and endosomal sorting complex required for transported (ESCRT) machinery were explored. Among 17 candidate proteins, only the charged multivesicular body protein 4 (CHMP4) paralogues were found to interact more strongly with the NDV wild-type M protein (M-WT) than with the mutated M protein (M-F23A). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Circulating miRNAs are informative to identify patients with different prognosis among those with heterogeneous response after trastuzumab-based neoadjuvant treatment, and may be an exploitable tool to select candidates for salvage adjuvant therapy.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further genome mining uncovered 36 candidate gene clusters, most of which were uncharacterized. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The HSCT patients who received immunosuppressive therapy with MMF and cyclosporine, as well as treatment with CBP were screened as potential candidates. Patients who lacked MPA C(0) measurements before or during CBP use, had combination therapy of rifampin with MMF, or switched from IV to oral MMF were excluded. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study carefully suggests eugenol is a candidate compound of developing drugs and supplement agents against SARS-CoV-2 and its Omicron variants.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nevertheless, other less explored immune checkpoints may be promising candidates for medulloblastoma therapy. OBJECTIVES: In the present study, we aimed to characterize the expression profile of 19 immune checkpoints in medulloblastoma. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, it was inferred that FIS could serve as a therapeutic candidate against arsenic-generated male reproductive toxicity attributing to its anti-oxidant, anti-lipoperoxidative, anti-apoptotic, and androgenic efficacy.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: The data suggest that HLA-DR4-restricted TCRs specific for the TGFβR2(-1) recurrent neoantigen can be valuable candidates for adoptive T cell therapy of a sizeable number of patients with cancer.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Data were collected from sixteen candidates regarding independent demographic and clinical factors, including Spinal Neoplastic Instability Score (SINS). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These results suggested that these genes may be the candidates that regulate anthocyanin biosynthesis of A. comosus var. bracteatus in the flower, leaf, and bract, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso