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133161por Zeng, Chenjie, Guo, Xingyi, Long, Jirong, Kuchenbaecker, Karoline B., Droit, Arnaud, Michailidou, Kyriaki, Ghoussaini, Maya, Kar, Siddhartha, Freeman, Adam, Hopper, John L., Milne, Roger L., Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Agata, Simona, Ahmed, Shahana, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Arason, Adalgeir, Arndt, Volker, Arun, Banu K., Arver, Brita, Bacot, Francois, Barrowdale, Daniel, Baynes, Caroline, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Blot, William J., Bogdanova, Natalia V., Bojesen, Stig E., Bonanni, Bernardo, Borresen-Dale, Anne-Lise, Brand, Judith S., Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S., Cai, Qiuyin, Caldes, Trinidad, Campbell, Ian, Carpenter, Jane, Chang-Claude, Jenny, Choi, Ji-Yeob, Claes, Kathleen B. M., Clarke, Christine, Cox, Angela, Cross, Simon S., Czene, Kamila, Daly, Mary B., de la Hoya, Miguel, De Leeneer, Kim, Devilee, Peter, Diez, Orland, Domchek, Susan M., Doody, Michele, Dorfling, Cecilia M., Dörk, Thilo, dos-Santos-Silva, Isabel, Dumont, Martine, Dwek, Miriam, Dworniczak, Bernd, Egan, Kathleen, Eilber, Ursula, Einbeigi, Zakaria, Ejlertsen, Bent, Ellis, Steve, Frost, Debra, Lalloo, Fiona, Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, Friedlander, Michael, Friedman, Eitan, Gambino, Gaetana, Gao, Yu-Tang, Garber, Judy, García-Closas, Montserrat, Gehrig, Andrea, Damiola, Francesca, Lesueur, Fabienne, Mazoyer, Sylvie, Stoppa-Lyonnet, Dominique, Giles, Graham G., Godwin, Andrew K., Goldgar, David E., González-Neira, Anna, Greene, Mark H., Guénel, Pascal, Haeberle, Lothar, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Hansen, Thomas V. O., Hart, Steven, Hartikainen, Jaana M., Hartman, Mikael, Hassan, Norhashimah, Healey, Sue, Hogervorst, Frans B. L., Verhoef, Senno, Hendricks, Carolyn B., Hillemanns, Peter, Hollestelle, Antoinette, Hulick, Peter J., Hunter, David J., Imyanitov, Evgeny N., Isaacs, Claudine, Ito, Hidemi, Jakubowska, Anna, Janavicius, Ramunas, Jaworska-Bieniek, Katarzyna, Jensen, Uffe Birk, John, Esther M., Joly Beauparlant, Charles, Jones, Michael, Kabisch, Maria, Kang, Daehee, Karlan, Beth Y., Kauppila, Saila, Kerin, Michael J., Khan, Sofia, Khusnutdinova, Elza, Knight, Julia A., Konstantopoulou, Irene, Kraft, Peter, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Le Marchand, Loic, Lee, Chuen Neng, Lee, Min Hyuk, Lester, Jenny, Li, Jingmei, Liljegren, Annelie, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Mai, Phuong L., Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, McGuffog, Lesley, Meindl, Alfons, Menegaux, Florence, Montagna, Marco, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Newcomb, Polly A., Nord, Silje, Nussbaum, Robert L., Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olswold, Curtis, Osorio, Ana, Papi, Laura, Park-Simon, Tjoung-Won, Paulsson-Karlsson, Ylva, Peeters, Stephanie, Peissel, Bernard, Peterlongo, Paolo, Peto, Julian, Pfeiler, Georg, Phelan, Catherine M., Presneau, Nadege, Radice, Paolo, Rahman, Nazneen, Ramus, Susan J., Rashid, Muhammad Usman, Rennert, Gad, Rhiem, Kerstin, Rudolph, Anja, Salani, Ritu, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K, Schmutzler, Rita K., Schoemaker, Minouk J., Schürmann, Peter, Seynaeve, Caroline, Shen, Chen-Yang, Shrubsole, Martha J., Shu, Xiao-Ou, Sigurdson, Alice, Singer, Christian F., Slager, Susan, Soucy, Penny, Southey, Melissa, Steinemann, Doris, Swerdlow, Anthony, Szabo, Csilla I., Tchatchou, Sandrine, Teixeira, Manuel R., Teo, Soo H., Terry, Mary Beth, Tessier, Daniel C., Teulé, Alex, Thomassen, Mads, Tihomirova, Laima, Tischkowitz, Marc, Toland, Amanda E., Tung, Nadine, Turnbull, Clare, van den Ouweland, Ans M. W., van Rensburg, Elizabeth J., ven den Berg, David, Vijai, Joseph, Wang-Gohrke, Shan, Weitzel, Jeffrey N., Whittemore, Alice S., Winqvist, Robert, Wong, Tien Y., Wu, Anna H., Yannoukakos, Drakoulis, Yu, Jyh-Cherng, Pharoah, Paul D. P., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison M., Simard, Jacques, Couch, Fergus J., Antoniou, Antonis C., Easton, Douglas F., Zheng, Wei“…SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. …”
Publicado 2016
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133162por Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H. Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Abdo Rizk, Mohamed, Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R. Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy, Willis, Paul A.“…Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal chemistry programs. …”
Publicado 2016
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133163por Kumar, Dilip, Puan, Kia Joo, Andiappan, Anand Kumar, Lee, Bernett, Westerlaken, Geertje H. A., Haase, Doreen, Melchiotti, Rossella, Li, Zhuang, Yusof, Nurhashikin, Lum, Josephine, Koh, Geraldine, Foo, Shihui, Yeong, Joe, Alves, Alexessander Couto, Pekkanen, Juha, Sun, Liang Dan, Irwanto, Astrid, Fairfax, Benjamin P., Naranbhai, Vivek, Common, John E. A., Tang, Mark, Chuang, Chin Keh, Jarvelin, Marjo-Riitta, Knight, Julian C., Zhang, Xuejun, Chew, Fook Tim, Prabhakar, Shyam, Jianjun, Liu, Wang, De Yun, Zolezzi, Francesca, Poidinger, Michael, Lane, E. Birgitte, Meyaard, Linde, Rötzschke, Olaf“…BACKGROUND: Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. …”
Publicado 2017
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133164por Zhang, Mingfeng, Wang, Zhaoming, Obazee, Ofure, Jia, Jinping, Childs, Erica J., Hoskins, Jason, Figlioli, Gisella, Mocci, Evelina, Collins, Irene, Chung, Charles C., Hautman, Christopher, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Kamineni, Aruna, Kolonel, Laurence N., Kulke, Matthew H., Malats, Núria, Olson, Sara H., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Brais, Lauren, Bueno-de-Mesquita, H. Bas, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Bijlsma, Maarten F., Brenner, Hermann, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Cavestro, Giulia Martina, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Boggi, Ugo, Gaziano, J. Michael, Gazouli, Maria, Giovannucci, Edward L., Goggins, Michael, Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Hu, Nan, Hunter, David J., Iskierka-Jazdzewska, Elzbieta, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., Landi, Maria T., Landi, Stefano, Marchand, Le Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Neale, Rachel E., Oberg, Ann L., Panico, Salvatore, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Porta, Miquel, Purdue, Mark, Quiros, J. Ramón, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Scelo, Ghislaine, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Strobel, Oliver, Sund, Malin, Małecka-Panas, Ewa, Taylor, Philip R., Tavano, Francesca, Travis, Ruth C., Thornquist, Mark, Tjønneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vashist, Yogesh, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Kooperberg, Charles, Risch, Harvey A., Jacobs, Eric J., Li, Donghui, Fuchs, Charles, Hoover, Robert, Hartge, Patricia, Chanock, Stephen J., Petersen, Gloria M., Stolzenberg-Solomon, Rachael S., Wolpin, Brian M., Kraft, Peter, Klein, Alison P., Canzian, Federico, Amundadottir, Laufey T.“…We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7×10(−8)). …”
Publicado 2016
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133165por Eldomery, Mohammad K., Coban-Akdemir, Zeynep, Harel, Tamar, Rosenfeld, Jill A., Gambin, Tomasz, Stray-Pedersen, Asbjørg, Küry, Sébastien, Mercier, Sandra, Lessel, Davor, Denecke, Jonas, Wiszniewski, Wojciech, Penney, Samantha, Liu, Pengfei, Bi, Weimin, Lalani, Seema R., Schaaf, Christian P., Wangler, Michael F., Bacino, Carlos A., Lewis, Richard Alan, Potocki, Lorraine, Graham, Brett H., Belmont, John W., Scaglia, Fernando, Orange, Jordan S., Jhangiani, Shalini N., Chiang, Theodore, Doddapaneni, Harsha, Hu, Jianhong, Muzny, Donna M., Xia, Fan, Beaudet, Arthur L., Boerwinkle, Eric, Eng, Christine M., Plon, Sharon E., Sutton, V. Reid, Gibbs, Richard A., Posey, Jennifer E., Yang, Yaping, Lupski, James R.“…RESULTS: Analysis of all possible modes of Mendelian inheritance, focusing on both single nucleotide variants (SNV) and copy number variant (CNV) alleles, yielded a likely contributory variant in 36% (27/74) of cases. If one includes candidate genes with variants identified within a single family, a potential contributory variant was identified in a total of ~51% (38/74) of cases enrolled in this pilot study. …”
Publicado 2017
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133166por Seabury, Christopher M., Oldeschulte, David L., Saatchi, Mahdi, Beever, Jonathan E., Decker, Jared E., Halley, Yvette A., Bhattarai, Eric K., Molaei, Maral, Freetly, Harvey C., Hansen, Stephanie L., Yampara-Iquise, Helen, Johnson, Kristen A., Kerley, Monty S., Kim, JaeWoo, Loy, Daniel D., Marques, Elisa, Neibergs, Holly L., Schnabel, Robert D., Shike, Daniel W., Spangler, Matthew L., Weaber, Robert L., Garrick, Dorian J., Taylor, Jeremy F.“…CONCLUSIONS: Fourteen moderate to large-effect QTL regions which ranged from being physically proximal (lead SNPs ≤ 3Mb) to fully overlapping for RFI, DMI, ADG, and MMWT were detected within and between populations, and included evidence for pleiotropy, proximal but independent causal mutations, and multi-breed QTL. Bovine positional candidate genes for these traits were functionally conserved across vertebrate species. …”
Publicado 2017
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133167por Schormair, Barbara, Zhao, Chen, Bell, Steven, Tilch, Erik, Salminen, Aaro V, Pütz, Benno, Dauvilliers, Yves, Stefani, Ambra, Högl, Birgit, Poewe, Werner, Kemlink, David, Sonka, Karel, Bachmann, Cornelius G, Paulus, Walter, Trenkwalder, Claudia, Oertel, Wolfgang H, Hornyak, Magdolna, Teder-Laving, Maris, Metspalu, Andres, Hadjigeorgiou, Georgios M, Polo, Olli, Fietze, Ingo, Ross, Owen A, Wszolek, Zbigniew, Butterworth, Adam S, Soranzo, Nicole, Ouwehand, Willem H, Roberts, David J, Danesh, John, Allen, Richard P, Earley, Christopher J, Ondo, William G, Xiong, Lan, Montplaisir, Jacques, Gan-Or, Ziv, Perola, Markus, Vodicka, Pavel, Dina, Christian, Franke, Andre, Tittmann, Lukas, Stewart, Alexandre F R, Shah, Svati H, Gieger, Christian, Peters, Annette, Rouleau, Guy A, Berger, Klaus, Oexle, Konrad, Di Angelantonio, Emanuele, Hinds, David A, Müller-Myhsok, Bertram, Winkelmann, Juliane“…INTERPRETATION: Identification of new candidate genes and associated pathways will inform future functional research. …”
Publicado 2017
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133168por Franzmeier, Nicolai, Düzel, Emrah, Jessen, Frank, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Haass, Christian, Suárez-Calvet, Marc, Fagan, Anne M, Paumier, Katrina, Benzinger, Tammie, Masters, Colin L, Morris, John C, Perneczky, Robert, Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Teipel, Stefan, Kilimann, Ingo, Ramirez, Alfredo, Rossor, Martin, Jucker, Mathias, Chhatwal, Jasmeer, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Falkai, Peter, Fliessbach, Klaus, Heneka, Michael T, Laske, Christoph, Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J, Franke, Christiana, Schneider, Anja, Kofler, Barbara, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Araque Caballero, Miguel Ángel, Metzger, Coraline, Bittner, Daniel, Weiner, Michael, Lee, Jae-Hong, Salloway, Stephen, Danek, Adrian, Goate, Alison, Schofield, Peter R, Bateman, Randall J, Ewers, Michael“…Higher functional MRI-assessed functional connectivity of a hub in the left frontal cortex is a core candidate brain mechanism underlying reserve as it is associated with education (i.e. a protective factor often associated with higher reserve) and attenuated cognitive impairment in prodromal Alzheimer’s disease. …”
Publicado 2018
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133169por Xu, Chun-wei, Wang, Wen-xian, Chen, Yan-ping, Chen, Yu, Liu, Wei, Zhong, Li-hua, Chen, Fang-fang, Zhuang, Wu, Song, Zheng-bo, Chen, Xiao-hui, Huang, Yun-jian, Guan, Yan-fang, Yi, Xin, Lv, Tang-feng, Zhu, Wei-feng, Lu, Jian-ping, Wang, Xiao-jiang, Shi, Yi, Lin, Xian-dong, Chen, Gang, Song, Yong“…CONCLUSIONS: VENTANA IHC is a reliable and rapid screening tool used in routine pathologic laboratories for the identification of suitable candidates for ALK-targeted therapy. VENTANA IHC has moderate sensitivity and a slightly higher association with response to therapy with ALK inhibitors, and some VENTANA IHC-positive, but RT-PCR-negative cases may benefit from crizotinib.…”
Publicado 2018
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133170por Wen, Yingxia, Trinh, Hung V., Linton, Christine E., Tani, Chiara, Norais, Nathalie, Martinez-Guzman, DeeAnn, Ramesh, Priyanka, Sun, Yide, Situ, Frank, Karaca-Griffin, Selen, Hamlin, Christopher, Onkar, Sayali, Tian, Sai, Hilt, Susan, Malyala, Padma, Lodaya, Rushit, Li, Ning, Otten, Gillis, Palladino, Giuseppe, Friedrich, Kristian, Aggarwal, Yukti, LaBranche, Celia, Duffy, Ryan, Shen, Xiaoying, Tomaras, Georgia D., Montefiori, David C., Fulp, William, Gottardo, Raphael, Burke, Brian, Ulmer, Jeffrey B., Zolla-Pazner, Susan, Liao, Hua-Xin, Haynes, Barton F., Michael, Nelson L., Kim, Jerome H., Rao, Mangala, O’Connell, Robert J., Carfi, Andrea, Barnett, Susan W.“…All together, these results provide critical information allowing the consideration of these candidate gp120 proteins for future clinical evaluations in combination with a potent adjuvant.…”
Publicado 2018
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133171por Payne, Beth A., Ryan, Helen, Bone, Jeffrey, Magee, Laura A., Aarvold, Alice B., Mark Ansermino, J., Bhutta, Zulfiqar A., Bowen, Mary, Guilherme Cecatti, J., Chazotte, Cynthia, Crozier, Tim, de Pont, Anne-Cornélie J. M., Demirkiran, Oktay, Duan, Tao, Kallen, Marlot, Ganzevoort, Wessel, Geary, Michael, Goffman, Dena, Hutcheon, Jennifer A., Joseph, K. S., Lapinsky, Stephen E., Lataifeh, Isam, Li, Jing, Liskonova, Sarka, Hamel, Emily M., McAuliffe, Fionnuala M., O’Herlihy, Colm, Mol, Ben W. J., Seaward, P. Gareth R., Tadros, Ramzy, Togal, Turkan, Qureshi, Rahat, Vivian Ukah, U., Vasquez, Daniela, Wallace, Euan, Yong, Paul, Zhou, Vivian, Walley, Keith R., von Dadelszen, Peter“…Model development involved selection of candidate predictor variables based on prior evidence of effect, availability across study sites, and use of LASSO (Least Absolute Shrinkage and Selection Operator) model building after multiple imputation using chained equations to address missing data for variable selection. …”
Publicado 2018
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133172por Li, Peng-tao, Rashid, Md. Harun or, Chen, Ting-ting, Lu, Quan-wei, Ge, Qun, Gong, Wan-kui, Liu, Ai-ying, Gong, Ju-wu, Shang, Hai-hong, Deng, Xiao-ying, Li, Jun-wen, Li, Shao-qi, Xiao, Xiang-hui, Liu, Rui-xian, Zhang, Qi, Duan, Li, Zou, Xian-yan, Zhang, Zhen, Jiang, Xiao, Zhang, Ya, Peng, Ren-hai, Shi, Yu-zhen, Yuan, You-lu“…Gene functional annotation and expression quantity analysis indicated the important roles of the phenylpropanoid metabolic pathway and oxidation-reduction process in response to VW, which also provided plenty of candidate genes related to plant resistance. CONCLUSIONS: This study concentrates on the preliminary response to V991 infection by comparing the VW-resistant CSSL and its VW-susceptible recurrent parent. …”
Publicado 2019
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133173por Vidal, Roberto M., Muhsen, Khitam, Tennant, Sharon M., Svennerholm, Ann-Mari, Sow, Samba O., Sur, Dipika, Zaidi, Anita K. M., Faruque, Abu S. G., Saha, Debasish, Adegbola, Richard, Hossain, M. Jahangir, Alonso, Pedro L., Breiman, Robert F., Bassat, Quique, Tamboura, Boubou, Sanogo, Doh, Onwuchekwa, Uma, Manna, Byomkesh, Ramamurthy, Thandavarayan, Kanungo, Suman, Ahmed, Shahnawaz, Qureshi, Shahida, Quadri, Farheen, Hossain, Anowar, Das, Sumon K., Antonio, Martin, Mandomando, Inacio, Nhampossa, Tacilta, Acácio, Sozinho, Omore, Richard, Ochieng, John B., Oundo, Joseph O., Mintz, Eric D., O’Reilly, Ciara E., Berkeley, Lynette Y., Livio, Sofie, Panchalingam, Sandra, Nasrin, Dilruba, Farag, Tamer H., Wu, Yukun, Sommerfelt, Halvor, Robins-Browne, Roy M., Del Canto, Felipe, Hazen, Tracy H., Rasko, David A., Kotloff, Karen L., Nataro, James P., Levine, Myron M.“…Major CFs, components of multiple ETEC vaccine candidates, were detected in 66.0% of LT/ST and ST-only cases and were associated with MSD versus matched controls by conditional logistic regression (p≤0.006); major CFs detected in only 25.0% of LT-only cases weren’t associated with MSD. …”
Publicado 2019
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133174por Chandak, Giriraj R., Silver, Matt J., Saffari, Ayden, Lillycrop, Karen A., Shrestha, Smeeta, Sahariah, Sirazul Ameen, Di Gravio, Chiara, Goldberg, Gail, Tomar, Ashutosh Singh, Betts, Modupeh, Sajjadi, Sara, Acolatse, Lena, James, Philip, Issarapu, Prachand, Kumaran, Kalyanaraman, Potdar, Ramesh D., Prentice, Andrew M., Fall, Caroline H. D., Acolatse, Lena, Ahmed, Meraj, Betts, Modupeh, Chandak, Giriraj R., Chopra, Harsha, Cooper, Cyrus, Darboe, Momodou K., Di Gravio, Chiara, Fall, Caroline H. D., Gandhi, Meera, Goldberg, Gail R., Issarapu, Prachand, James, Philip, Janha, Ramatoulie, Jarjou, Landing M. A., Kaur, Lovejeet, Kehoe, Sarah H., Kumaran, Kalyanaraman, Lillycrop, Karen A., Ngum, Mohammed, Nongmaithem, Suraj S., Owens, Stephen, Potdar, Ramesh D., Prentice, Andrew M., Prentice, Ann, Priyanka, Tallapragada Divya Sri, Saffari, Ayden, Sahariah, Sirazul Ameen, Sajjadi, Sara, Sane, Harshad, Shrestha, Smeeta, Silver, Matt J., Tomar, Ashutosh Singh, Ward, Kate A., Yadav, Dilip Kumar, Yajnik, Chittaranjan S.“…Differences in DNA methylation between allocation groups will be identified using the Illumina Infinium MethylationEPIC array, and by pyrosequencing top hits and selected candidate loci. Associations will be analysed between DNA methylation and health-related phenotypic outcomes, including size at birth, and children’s post-natal growth, body composition, skeletal development, cardio-metabolic risk markers (blood pressure, serum lipids, plasma glucose and insulin) and cognitive function. …”
Publicado 2017
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133175por Medrano-Jiménez, Elisa, Jiménez-Ferrer Carrillo, Itzia, Pedraza-Escalona, Martha, Ramírez-Serrano, Cristina E., Álvarez-Arellano, Lourdes, Cortés-Mendoza, Javier, Herrera-Ruiz, Maribel, Jiménez-Ferrer, Enrique, Zamilpa, Alejandro, Tortoriello, Jaime, Pedraza-Alva, Gustavo, Pérez-Martínez, Leonor“…Therefore, M. parviflora phytochemicals represent an alternative to prevent cognitive impairment associated with a metabolic disorder as well as an effective prophylactic candidate for AD progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12974-019-1515-3) contains supplementary material, which is available to authorized users.…”
Publicado 2019
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133176por Lona-Durazo, Frida, Hernandez-Pacheco, Natalia, Fan, Shaohua, Zhang, Tongwu, Choi, Jiyeon, Kovacs, Michael A., Loftus, Stacie K., Le, Phuong, Edwards, Melissa, Fortes-Lima, Cesar A., Eng, Celeste, Huntsman, Scott, Hu, Donglei, Gómez-Cabezas, Enrique Javier, Marín-Padrón, Lilia Caridad, Grauholm, Jonas, Mors, Ole, Burchard, Esteban G., Norton, Heather L., Pavan, William J., Brown, Kevin M., Tishkoff, Sarah, Pino-Yanes, Maria, Beleza, Sandra, Marcheco-Teruel, Beatriz, Parra, Esteban J.“…Additionally, our analyses support the presence of multiple signals in the OCA2/HERC2/APBA2 region on chromosome 15. A clear causal candidate is the HERC2 intronic variant rs12913832, which has a profound influence on OCA2 expression. …”
Publicado 2019
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133177por Gawel, Danuta R., Serra-Musach, Jordi, Lilja, Sandra, Aagesen, Jesper, Arenas, Alex, Asking, Bengt, Bengnér, Malin, Björkander, Janne, Biggs, Sophie, Ernerudh, Jan, Hjortswang, Henrik, Karlsson, Jan-Erik, Köpsen, Mattias, Lee, Eun Jung, Lentini, Antonio, Li, Xinxiu, Magnusson, Mattias, Martínez-Enguita, David, Matussek, Andreas, Nestor, Colm E., Schäfer, Samuel, Seifert, Oliver, Sonmez, Ceylan, Stjernman, Henrik, Tjärnberg, Andreas, Wu, Simon, Åkesson, Karin, Shalek, Alex K., Stenmarker, Margaretha, Zhang, Huan, Gustafsson, Mika, Benson, Mikael“…Diagnostic validation studies were performed using expression profiling data and potential protein biomarkers from prospective clinical studies of 13 diseases. A candidate drug was examined by a treatment study of a mouse model of arthritis, using phenotypic, immunohistochemical, and cellular analyses as read-outs. …”
Publicado 2019
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133178por Loupy, Alexandre, Aubert, Olivier, Orandi, Babak J, Naesens, Maarten, Bouatou, Yassine, Raynaud, Marc, Divard, Gillian, Jackson, Annette M, Viglietti, Denis, Giral, Magali, Kamar, Nassim, Thaunat, Olivier, Morelon, Emmanuel, Delahousse, Michel, Kuypers, Dirk, Hertig, Alexandre, Rondeau, Eric, Bailly, Elodie, Eskandary, Farsad, Böhmig, Georg, Gupta, Gaurav, Glotz, Denis, Legendre, Christophe, Montgomery, Robert A, Stegall, Mark D, Empana, Jean-Philippe, Jouven, Xavier, Segev, Dorry L, Lefaucheur, Carmen“…MAIN OUTCOME MEASURE: Allograft failure (return to dialysis or pre-emptive retransplantation). 32 candidate prognostic factors for kidney allograft survival were assessed. …”
Publicado 2019
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133179por Scott, Jan, Hidalgo-Mazzei, Diego, Strawbridge, Rebecca, Young, Allan, Resche-Rigon, Matthieu, Etain, Bruno, Andreassen, Ole A., Bauer, Michael, Bennabi, Djamila, Blamire, Andrew M., Boumezbeur, Fawzi, Brambilla, Paolo, Cattane, Nadia, Cattaneo, Annamaria, Chupin, Marie, Coello, Klara, Cointepas, Yann, Colom, Francesc, Cousins, David A., Dubertret, Caroline, Duchesnay, Edouard, Ferro, Adele, Garcia-Estela, Aitana, Goikolea, Jose, Grigis, Antoine, Haffen, Emmanuel, Høegh, Margrethe C., Jakobsen, Petter, Kalman, Janos L., Kessing, Lars V., Klohn-Saghatolislam, Farah, Lagerberg, Trine V., Landén, Mikael, Lewitzka, Ute, Lutticke, Ashley, Mazer, Nicolas, Mazzelli, Monica, Mora, Cristina, Muller, Thorsten, Mur-Mila, Estanislao, Oedegaard, Ketil Joachim, Oltedal, Leif, Pålsson, Erik, Papadopoulos Orfanos, Dimitri, Papiol, Sergi, Perez-Sola, Victor, Reif, Andreas, Ritter, Philipp, Rossi, Roberto, Schulze, Thomas, Senner, Fanny, Smith, Fiona E., Squarcina, Letizia, Steen, Nils Eiel, Thelwall, Pete E., Varo, Cristina, Vieta, Eduard, Vinberg, Maj, Wessa, Michele, Westlye, Lars T., Bellivier, Frank“…Novel elements of this study include the recruitment of a large, multinational, clinically representative sample specifically for the purpose of studying candidate biomarkers and biosignatures; the application of lithium-7 magnetic resonance imaging to explore the distribution of lithium in the brain; development of a digital phenotype (using actigraphy and ecological momentary assessment) to monitor daily variability in symptoms; and economic modelling of the cost-effectiveness of introducing biomarker tests for the customisation of lithium treatment into clinical practice. …”
Publicado 2019
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133180por Beaton, Laura, Tregidgo, Henry F J, Znati, Sami A, Forsyth, Sharon, Clarkson, Matthew J, Bandula, Steven, Chouhan, Manil, Lowe, Helen L, Zaw Thin, May, Hague, Julian, Sharma, Dinesh, Pollok, Joerg-Matthias, Davidson, Brian R, Raja, Jowad, Munneke, Graham, Stuckey, Daniel J, Bascal, Zainab A, Wilde, Paul E, Cooper, Sarah, Ryan, Samantha, Czuczman, Peter, Boucher, Eveline, Hartley, John A, Lewis, Andrew L, Jansen, Marnix, Meyer, Tim, Sharma, Ricky A“…Eligible patients have a diagnosis of colorectal liver metastases, or HCC (Childs Pugh A), diagnosed histologically or radiologically, and are candidates for liver surgery. All patients are followed up for 28 days following surgery. …”
Publicado 2019
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