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  1. 133341
    “…The functional role of miR-200c-3p in the viability, proliferation, migration and invasion of GCC cells were evaluated by CCK-8, EdU, wound healing and Transwell assays. In addition, the candidate targets of miR-200c-3p was predicted and confirmed by dual-luciferase reporter assay. …”
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    MiR-200c-3p aggravates gastric cell carcinoma via KLF6
  2. 133342
    “…Here, we propose VPA as a potential candidate to tackle COVID-19, in which rapid viral spread and replication, and hyperinflammation are crucial elements. …”
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    Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity
  3. 133343
    “…A pilot survey with an independent sample of 34 clinicians revealed that 85% of clinicians found information on prognosis useful and that 79% thought that they should have access to the Informatics Consult as a service within their healthcare systems. We identified candidate steps for automation to scale evidence generation and to accelerate the return of results. …”
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    An informatics consult approach for generating clinical evidence for treatment decisions
  4. 133344
    “…Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to nucleoside analogue-based therapy. …”
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    Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
  5. 133345
    “…In this study, we sought to develop, characterize and assess whether chimeric heavy chain only antibodies (cHcAbs) against CTLA4 are viable therapeutic candidates for the treatment of canine cancers. Anti-CTLA4 nanobodies (Nbs) were identified from a yeast nanobody (Nb) library using magnetic-assisted cell sorting (MACS) and flow cytometry. cHcAbs were engineered by genetically fusing the DNA sequences coding for anti-CTLA4 Nbs with the Fc domain of the subclass B of canine IgG. …”
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    Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients
  6. 133346
    “…In bivariate logistic regression analyses, variables with p-value< 0.25 were considered as potential candidates for multivariable logistic regression analyses. …”
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    Fear of falling and associated factors among older people living in Bahir Dar City, Amhara, Ethiopia- a cross-sectional study
  7. 133347
    “…Importantly, over-expression of some of these candidate TFs increased anthocyanin accumulation in tobacco leaves which provided important evidence for the role of these TFs in flower color formation probably via regulating key structural genes of the anthocyanin pathway. …”
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    Comparative transcriptome analysis identified important genes and regulatory pathways for flower color variation in Paphiopedilum hirsutissimum
  8. 133348
    “…RESULTS: Of the 1592 candidate studies, twenty-one eligible studies met our inclusion criteria. …”
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    Paediatric tuberculosis diagnosis using Mycobacterium tuberculosis real-time polymerase chain reaction assay: a systematic review and meta-analysis
  9. 133349
    “…To identify potential cis-regulatory elements (CREs) for transcriptional upregulation at cool temperature, we analyzed temperature effects on DNA accessibility in chromatin of S2R+ cells. Candidate cis-regulatory elements (CREs) were evaluated with a novel reporter assay for accurate assessment of their temperature-dependency. …”
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    A cis-regulatory element promoting increased transcription at low temperature in cultured ectothermic Drosophila cells
  10. 133350
    “…Our association study identified the chemotaxis inhibitory protein (chp) as a strong candidate for involvement in the increased virulence potential of ST59. …”
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    Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China
  11. 133351
    “…Subject to debate is, however, whether patients with a pCR to NAC benefit from RC, which is a major surgical procedure with substantial morbidity, and if these patients might be candidates for close surveillance instead. However, currently it is not possible to accurately identify patients with a pCR to NAC in whom RC might be withheld. …”
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    Prediction of pathological response following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer: the PRE-PREVENCYS trial
  12. 133352
    “…Moreover, there was a differential response of tissue specific hMSCs after pre-conditioning with Dex during mixed lymphocyte reaction, wherein UC-MSCs and DP-MSCs showed enhanced immunosuppression as compared to AD-MSCs and BM-MSCs, thereby proving to be a better candidate for therapeutic applications in immune-related diseases. …”
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    Dexamethasone priming enhances stemness and immunomodulatory property of tissue-specific human mesenchymal stem cells
  13. 133353
    “…The area under curve was calculated to estimate the accuracy of candidate gene models in evaluating chemotherapy sensitivity. …”
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    Model constructions of chemosensitivity and prognosis of high grade serous ovarian cancer based on evaluation of immune microenvironment and immune response
  14. 133354
    “…Our analyses highlight how multiple IBD gene candidates can impact on epithelial structure and function, including the protection of the mucosa from intestinal microbiota, and demonstrate that DUSP16 acts a regulator of MAPK activity and contributes to mucosal defense, in part via its regulation of the polymeric immunoglobulin receptor, involved in the protection of the intestinal mucosa from enteric microbiota. …”
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    Functional screen of inflammatory bowel disease genes reveals key epithelial functions
  15. 133355
    “…CONCLUSIONS: The QTL isolated in ‘Shavtsitska’ and present in the Caucasian V. vinifera varieties could be a new candidate gene of resistance to E. necator to use in breeding programmes. …”
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    Construction of a high-density genetic map and detection of a major QTL of resistance to powdery mildew (Erysiphe necator Sch.) in Caucasian grapes (Vitis vinifera L.)
  16. 133356
    “…Yeast two-hybrid assay screened interacting proteins of STOML2, followed by bioinformatics analysis to predict biological function and signaling pathway of candidate proteins. Target protein with most functional similarity to STOML2 was validated with co-immunoprecipitation, and immunofluorescence were conducted to co-localize STOML2 and PHB. …”
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    STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation
  17. 133357
    “…Through bioinformatics analysis, five genes (LOC_Os09g12440, LOC_Os09g12470, LOC_Os09g12520, LOC_Os09g12580 and LOC_Os09g12720) were identified as candidates for qSR9. CONCLUSION: This natural population consisting of 211 rice landraces combined with high-density SNPs will serve as a better choice for identifying rice QTLs/genes in the future, and the detected QTLs associated with cold tolerance at the bud burst stage in rice will be conducive to further mining favorable genes and breeding rice varieties under cold stress. …”
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    Identification of cold tolerance QTLs at the bud burst stage in 211 rice landraces by GWAS
  18. 133358
    “…These antibody cocktails are highly promising candidate tools for controlling new SARS-CoV-2 variants, including Delta.…”
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    Antibody cocktail effective against variants of SARS-CoV-2
  19. 133359
    “…CONCLUSIONS: In this large cohort of DM1 patients, we reported an inverse and independent association of miR-146a-5p with diabetes chronic complications and in particular with CVD and retinopathy, suggesting that miR-146a-5p may be a novel candidate biomarker of DM1 complications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-03142-4.…”
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    MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS
  20. 133360
    por Guan, Ming
    Publicado 2021
    “…METHODS: A cross-sectional study was employed to explore the associations among SRH knowledge, sexual attitudes, and sexual behaviour with a publicly available survey data among the 1196 university students from freshmen to Ph.D. candidates. Descriptive analysis was used to describe the sociodemographic characteristics of the university students by gender. …”
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    Sexual and reproductive health knowledge, sexual attitudes, and sexual behaviour of university students: Findings of a Beijing-Based Survey in 2010-2011
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