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  1. 133521
    “…BACKGROUND: Research shows that even the short-term administration of inhaled drugs immediately before surgery can improve respiratory function in surgical candidates with chronic obstructive pulmonary disease (COPD). …”
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    Preoperative inhalation therapy for patients with chronic obstructive pulmonary disease undergoing lung surgery: a retrospective study
  2. 133522
    “…CONCLUSION: These data demonstrated that HRS can improve survival rate, attenuate neuroinflammation, astrocyte and microglial activation, neuronal injury and mitochondrial dysfunction in juvenile SAE rat model, making it a potential therapeutic candidate in treating paediatric SAE.…”
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    Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy
  3. 133523
    “…The long-lasting residual efficacy and unique mode of action of the SemiShield(™) 50WG shows that it could be an ideal product to be considered as a potential candidate insecticide formulation for IRS in malaria endemic countries such as Ethiopia or other sub-Saharan countries where the transmission season lasts up to four months or longer. …”
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    Residual efficacy of SumiShield™ 50WG for indoor residual spraying in Ethiopia
  4. 133524
    “…METHODS: A total of 123 candidates were retrospectively included in this multicenter study and 55 LVNC patients (mean age, 45.7 ± 16.2 years; 61.8% men) remained after applying the exclusion criteria. …”
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    Prognostic value of cardiac magnetic resonance imaging parameters in left ventricular noncompaction with left ventricular dysfunction
  5. 133525
    “…Among them, CeqSnRK3.16 expression was significantly up-regulated under various salt treatments, identifying this as a candidate gene salt stress tolerance gene. In addition, CeqSnRK3.16 showed significant expression change correlations with multiple genes under salt stress, indicating that it might exhibit synergistic effects with other genes in response to salt stress. …”
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    Comprehensive identification and expression analyses of the SnRK gene family in Casuarina equisetifolia in response to salt stress
  6. 133526
    por Shi, Haojun, Tsang, Yiusing, Yang, Yisi
    Publicado 2022
    “…CONCLUSIONS: Our findings suggest that CEACAM5 is a candidate stemness-related innate immune checkpoint in pancreatic cancer, and is potentially regulated by prostanoid and long-chain unsaturated fatty acid metabolic processes. …”
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    Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer
  7. 133527
    “…The Bayesian univariate and bivariate latent class models (LCMs) were applied to estimate the ability of the candidate bacterial markers in order to early detection of patients with CRC. …”
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    Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer
  8. 133528
    “…Loss of chromosome Y (LOY) is a risk factor candidate in COVID-19 due to its prior association with many chronic age-related diseases, and its impact on immune gene transcription. …”
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    Loss of Y in leukocytes as a risk factor for critical COVID-19 in men
  9. 133529
    “…CONCLUSIONS: The adoption of weighted radiomic features from multiple intrapulmonary lesions has the potential to predict long-term PFS benefits for patients who are candidates for PD-1/PD-L1 immunotherapies. KEY POINTS: • Weighted radiomic-based model derived from multiple intrapulmonary lesions on pre-treatment CT images has the potential to predict durable clinical benefits of immunotherapy in lung cancer. • Early line immunotherapy is associated with longer progression-free survival in advanced lung cancer. …”
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    A pre-treatment CT-based weighted radiomic approach combined with clinical characteristics to predict durable clinical benefits of immunotherapy in advanced lung cancer
  10. 133530
    “…The multi-omics network was applied to the Pharmomics pipeline in Mergeomics to identify drug candidates for T2D treatment. Then, we used the drug-gene interaction network to conduct network pharmacological analysis. …”
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    Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration
  11. 133531
    “…METHODS: We performed simulated vaccine efficacy trial (SiVET) using licensed hepatitis B vaccines as substitutes for a HIV vaccine candidate and included randomization for those immune to hep B. …”
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    Feasibility of conducting HIV prevention trials among key populations in Nairobi, Kenya
  12. 133532
    “…Further study is recommended to evaluate the molecular mechanisms to which these anti-atherogenic and cardio-protective actions can be attributed and exploit the GCMS result in the development of drug candidates.…”
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    Anti-atherogenic and cardio-protective properties of sweet melon (Cucumis melo. L. Inodorus) seed extract on high fat diet induced obesity in male wistar rats
  13. 133533
    “…Variable with P < 0.25 in the bivariable analysis was a candidate for multivariable analysis to control confounding effect. …”
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    Behavioral responses for facemask use messages to prevent COVID-19 among residents of Bahir Dar City, Ethiopia: an application of extended parallel process model
  14. 133534
    por Lu, Zhimin, Fei, Lihong, Hou, Guoxin
    Publicado 2022
    “…CONCLUSIONS: Herein, we reported a comprehensive investigation of the tumor-promoting role of ERCC6L in various cancer types. ERCC6L is a candidate biomarker for diagnosing and unfavorable prognosis of specific cancers. …”
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    A pan-cancer analysis of the oncogenic role of ERCC6L
  15. 133535
    “…We greatly expand the novel diversity of Thermoproteia, Patescibacteria (Candidate Phyla Radiation, CPR), and Chloroflexota found at deep-sea hydrothermal vents and identify a small sampling of two potentially novel phyla, designated JALSQH01 and JALWCF01. …”
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    Global patterns of diversity and metabolism of microbial communities in deep-sea hydrothermal vent deposits
  16. 133536
    “…In our prior genetic study of 184 PML cases, we discovered 19 candidate PML risk variants. In the current study of another 152 cases, we validated 4 of 19 variants in both population controls (gnomAD 3.1) and matched controls (JCV+ multiple sclerosis patients on a PML-linked drug ≥ 2 years). …”
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    Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies
  17. 133537
    “…Data sets were further analyzed through the ingenuity pathway analysis (QIAGEN) and integrative gene set enrichment to identify candidate networks, signaling pathways, and upstream regulators. …”
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    Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
  18. 133538
    “…Hyperbaric oxygen (HBO(2)) is a candidate drug. METHODS: The objective of this interim analysis is to describe our cohort and evaluate the safety of HBO(2) for post covid condition. …”
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    Hyperbaric oxygen therapy for long COVID (HOT-LoCO), an interim safety report from a randomised controlled trial
  19. 133539
    “…DE-CMGs were then used for the coexpression network construction to screen candidate key genes associated with PAH. Furthermore, the predictive performance of the model was verified by receiver operating characteristic (ROC) analysis, and genes with area under the curve (AUC) values greater than 0.8 were selected as diagnostic genes. …”
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    Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension
  20. 133540
    “…CONCLUSION: This study suggests FA_gene and DMN_miRNA algorithms for biomarker discovery, which lead us to a list of important players in ASD with potential roles in the nervous system or neurological disorders that can be experimentally investigated as candidates for ASD diagnostic tests. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-023-01439-5.…”
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    Biomarker prediction in autism spectrum disorder using a network-based approach
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