“…Thus, our results identify the direct targeting of the viral RNA genome (ORF1a/b) by siRNAs as highly efficient and introduce siV1 as a particularly promising drug candidate for therapeutic intervention.…”
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“…Initial collections of volatiles from virgin male and female CRB-G adults from the Solomon Islands failed to show any male- or female-specific compounds as candidate pheromone components. Only after five months were significant quantities of ethyl 4-methyloctanoate and 4-methyloctanoic acid produced by males but not by females. …”
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“…Overall, considering the main role of cathepsins and FAA in buoyancy acquisition process and therefore in both embryo quality and viability, our study identifies good marker candidates to evaluate embryo quality in the farming of this species.…”
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“…Thus, PARPi, olaparib, would be a promising candidate as a radio-sensitizer for BRCA mut TNBC treatment, especially for C-ion radiotherapy.…”
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“…Conclusions: NLR could be a candidate easy, fast, and low-cost marker of disease progression and survival in ALS. …”
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“…We also identified specific loci shared between migraine and each of depression and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for experimental validation.…”
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“…Conclusion: With high-yield (133)La cyclotron production, recovery of BaCO(3) target material, and fundamental imaging characteristics superior to those of (68)Ga and (132)La, (133)La represents a promising radiometal candidate to provide high-resolution PET imaging as a PET/α-therapy theranostic pair with (225)Ac or as a PET/Auger electron therapy theranostic pair with (135)La.…”
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“…Propolis may be a promising naturally-occurring candidate for the development of antimycotic drugs.…”
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“…A temporal mask of 50–60 ns was found to be optimal for maximising the discrimination of the photons resulting from the neutron capture by boron and gadolinium. A range of candidate detector and thermal neutron shielding materials were simulated, and detections meeting the proposed acceptance criteria (i.e. falling within the target energy window and arriving 60 ns post beam-off) were classified as true or false positives, depending on their origin. …”
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“…Moreover, correlation analysis revealed that the estimated parameters had predictive value for the self-reported pain experiences, suggesting that the altered cognitive parameters could be potential candidates for inclusion in chronic pain assessments. …”
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“…Accordingly, GNS561, for which a global phase 1b clinical trial in liver cancers was just successfully achieved, represents a promising new drug candidate and a hopeful therapeutic strategy in cancer treatment. …”
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“…Using a bioinformatics pipeline, we identified 333 candidate RxLR effectors in the strain INRA 310 of Phytophthora parasitica. …”
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“…OBJECTIVES: B cell-activating factor (BAFF), which is critical in the activation and differentiation of B cells, is a candidate diagnostic and predictive biomarker for antibody-mediated rejection (ABMR). …”
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“…Primary care clinics identified appropriate aspirin candidates, and clinicians received continuing education about aspirin. …”
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“…In particular, circulating plasma EVs and non-coding RNAs including miRNAs are interesting candidates as bearers of circulating biomarkers due to their high stability in the blood and making them highly relevant biomarkers for IS diagnostics.…”
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“…CONCLUSIONS: Our results demonstrate that A(2B)AR is a promising target in immunotherapy, identifying ISAM-R56A as the most potent candidate for A(2B)AR blockade. Inhibition of A(2B)AR signaling restores T cell function and proliferation. …”
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“…To diagnose the NMS, 21 elite female judokas were evaluated, belonging to different classification categories, divided into three groups: group I–category I (Cat. I), group II–candidates for Masters of Sports (CMS) and group III—Masters of Sports (MS).The evaluation of NMS was performed at the end of each two-week cycle, using 3 tests: T(max)—time to reach the maximum muscle contraction, (msec); F(y) –examination of elasticity indices in different muscles, (Hz); J–explosive muscular strength, (kg/s). …”
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“…BACKGROUND: The outcomes of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) who are not candidates for local salvage therapy and of those diagnosed with recurrent or metastatic disease are dismal. …”
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“…Thus, these compounds could behave as probable lead candidates for treatment against SARS-CoV-2. However further in vitro and in vivo studies are required for the development of medication against SARS-CoV-2.…”
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“…METHODS: Quantitative assessment of secondary data in the Type 2 Diabetes Knowledge Portal comprising nutritional phenotypic traits (peripheral vascular disease, hemoglobin A1C, triglycerides, low-density lipoprotein, fasting glucose, fasting insulin) and genetic associations risk allele, minor allele frequencies, reference single nucleotide polymorphisms, candidate genes, chromosomal regions, variant coordinates, and sequence variation impacts) related to Type 2 Diabetes Mellitus (T2DM) among adults of African ancestry with or without Type 2 Diabetes Mellitus to understand T2DM hereditary disease risk. …”
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