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134061“…Lovastatin is a potential drug candidate that can reduce the levels of cholesterol and low-density lipoprotein cholesterol in the blood, as well as prevent atherosclerosis and coronary heart disease. …”
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134062“…Low-molecular-weight glycoproteins (LMW-GPs) are considered promising candidates for disease biomarker discovery. Selective sorbents are essential for the extraction and enrichment of this class of compounds. …”
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134063por Grzybowski, Marcin Mikołaj, Stańczak, Paulina Seweryna, Pomper, Paulina, Błaszczyk, Roman, Borek, Bartłomiej, Gzik, Anna, Nowicka, Julita, Jędrzejczak, Karol, Brzezińska, Joanna, Rejczak, Tomasz, Güner-Chalimoniuk, Nazan Cemre, Kikulska, Agnieszka, Mlącki, Michał, Pęczkowicz-Szyszka, Jolanta, Olczak, Jacek, Gołębiowski, Adam, Dzwonek, Karolina, Dobrzański, Paweł, Zasłona, Zbigniew“…OATD-02 represents a very promising drug candidate for the combined treatment of tumours, and is the only pharmacological tool that can effectively address the benefits of ARG1/ARG2 inhibition. …”
Publicado 2022
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134064por Gao, Rong, Wang, Jin, He, Xuemin, Wang, Tongtong, Zhou, Li, Ren, Zhitao, Yang, Jifeng, Xiang, Xiaoxin, Wen, Shiyi, Yu, Zhuojun, Ai, Heying, Wang, Yuchan, Liang, Hua, Li, Shasha, Lu, Yan, Zhu, Yanhua, Shi, Guojun, Chen, Yanming“…THY1, COL1A1, COL1A2, COL3A1 and RHBDF1 could be served as candidate biomarkers to evaluate the progression of NAFLD.…”
Publicado 2022
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134065por Yao, Jingyue, Wang, Jubo, Xu, Ye, Guo, Qinglong, Sun, Yuening, Liu, Jian, Li, Sichan, Guo, Yongjian, Wei, Libin“…All of the findings reveal that mitophagy disruption is a promising strategy for HCC treatment and OA is a potential candidate for the development of mitophagy inhibitors. …”
Publicado 2021
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134066por Huang, Runzhi, Huang, Dan, Wang, Siqiao, Xian, Shuyuan, Liu, Yifan, Jin, Minghao, Zhang, Xinkun, Chen, Shaofeng, Yue, Xi, Zhang, Wei, Lu, Jianyu, Liu, Huizhen, Huang, Zongqiang, Zhang, Hao, Yin, Huabin“…Connectivity Map Analysis screened two candidate compounds, MS-275 and pyrvinium, that might target Ewing sarcoma. …”
Publicado 2022
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134067por Palmisciano, Paolo, Ferini, Gianluca, Khan, Ramlah, Bin-Alamer, Othman, Umana, Giuseppe E., Yu, Kenny, Cohen-Gadol, Aaron A., El Ahmadieh, Tarek Y., Haider, Ali S.“…Patients were eligible if they had histologically-proven primary tumors and ≤4 synchronous BMs candidate for non-urgent surgery and radiation. Patients with primary tumors clinically responsive to radiotherapy, prior brain radiation, and leptomeningeal metastases were deemed non-eligible. …”
Publicado 2022
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134068por Bougouma, Edith Christiane, Palacpac, Nirianne Marie Q., Tiono, Alfred B., Nebie, Issa, Ouédraogo, Alphonse, Houard, Sophie, Yagi, Masanori, Coulibaly, Sam Aboubacar, Diarra, Amidou, Tougan, Takahiro, Ouedraogo, Amidou Z., Soulama, Issiaka, Arisue, Nobuko, Yaro, Jean Baptiste, D’Alessio, Flavia, Leroy, Odile, Cousens, Simon, Horii, Toshihiro, Sirima, Sodiomon B.“…This is the first time the vaccine candidate was evaluated in young children below 5 years using two vaccination routes. …”
Publicado 2022
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134069por Li, Chang-Chun, Ullah, Muhammad Hasnain Ehsan, Lin, Xiao, Shan, Su-Kang, Guo, Bei, Zheng, Ming-Hui, Wang, Yi, Li, Fuxingzi, Yuan, Ling-Qing“…RESULTS: Our research obtained the top 9 candidate genes from the whole network (IFNA1, MRC1, LGALS3, LOX, POSTN, TIMP1, CD276, SDC4, and TLR2). …”
Publicado 2022
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134070por Yang, Shan, Liu, Mengshuang, Chu, Na, Chen, Guanxiu, Wang, Panpan, Mo, Junjie, Guo, Haifeng, Xu, Jianghuan, Zhou, Hongkai“…The Pearson correlation analysis showed a significant correlation between reduced glutathione and 16 genes (12 upregulated and four downregulated genes), suggesting these genes could be candidates as salt-tolerance regulation genes. Collectively, our data show that glutathione metabolism plays a critical role in response to SS in rice. …”
Publicado 2022
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134071P331 A screen to identify the regulators of genome stability in the human commensal Candida albicanspor Goyal, Rohit, Jaitly, Priya, Legrand, Melanie, Chauvel, Murielle, d'Enfert, Christophe, Sanyal, Kaustuv“…Further characterization and understanding of the regulatory mechanisms of these Candidate genes may reveal unknown pathways for maintaining genome stability and drug resistance. …”
Publicado 2022
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134072por You, Jia, Zhang, Ya-Ru, Wang, Hui-Fu, Yang, Ming, Feng, Jian-Feng, Yu, Jin-Tai, Cheng, Wei“…We implemented a data-driven strategy to identify predictors from 366 candidate variables covering a comprehensive range of genetic and environmental factors and developed the ML model to predict incident dementia and Alzheimer's Disease (AD) within five, ten, and much longer years (median 11.9 [Interquartile range 11.2–12.5] years). …”
Publicado 2022
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134073por Bivona, Derek J., Tallavajhala, Srikar, Abdi, Mohamad, Oomen, Pim J. A., Gao, Xu, Malhotra, Rohit, Darby, Andrew, Monfredi, Oliver J., Mangrum, J. Michael, Mason, Pamela, Mazimba, Sula, Salerno, Michael, Kramer, Christopher M., Epstein, Frederick H., Holmes, Jeffrey W., Bilchick, Kenneth C.“…OBJECTIVE: To use cardiac magnetic resonance (CMR) to define mechanisms of sex-based differences in outcomes after CRT and describe distinct CMR-based phenotypes of CRT candidates based on sex and non-ischemic/ischemic cardiomyopathy type. …”
Publicado 2022
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134074por Tapsoba, Jean de Dieu, Cover, Jane, Obong’o, Christopher, Brady, Martha, Cressey, Tim R., Mori, Kira, Okomo, Gordon, Kariithi, Edward, Obanda, Rael, Oluoch-Madiang, Daniel, Chen, Ying Qing, Drain, Paul, Duerr, Ann“…These AGYW may be optimal candidates for long-acting PrEP.…”
Publicado 2022
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134075Elite controllers long-term non progressors present improved survival and slower disease progressionpor Capa, Laura, Ayala-Suárez, Rubén, De La Torre Tarazona, Humberto Erick, González-García, Juan, del Romero, Jorge, Alcamí, José, Díez-Fuertes, Francisco“…EC-LTNP individuals represent one of the most favorable phenotypes of immune activation against HIV-1 found in nature and, therefore, are strong candidates to be considered a model of functional cure of HIV-1 infection.…”
Publicado 2022
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134076por Reuben, Aaron, Moffitt, Terrie E, Abraham, Wickliffe C, Ambler, Antony, Elliott, Maxwell L, Hariri, Ahmad R, Harrington, Honalee, Hogan, Sean, Houts, Renate M, Ireland, David, Knodt, Annchen R, Leung, Joan, Pearson, Amber, Poulton, Richie, Purdy, Suzanne C, Ramrakha, Sandhya, Rasmussen, Line J H, Sugden, Karen, Thorne, Peter R, Williams, Benjamin, Wilson, Graham, Caspi, Avshalom“…Knowledge of a person’s risk for Alzheimer’s disease and related dementias (ADRDs) is required to triage candidates for preventive interventions, surveillance, and treatment trials. …”
Publicado 2022
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134077por Feldmann, Daneil, Bope, Christian D., Patricios, Jon, Chimusa, Emile R., Collins, Malcolm, September, Alison V.“…Most implicated loci have been identified from candidate gene-based approach using case-control association settings. …”
Publicado 2022
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134078por Najafipour, Reza, Mohammadi, Davood, Estaki, Zohreh, Zarabadi, Kiana, Jalilvand, Manijeh, Moghbelinejad, Sahar“…Control samples were those with suspected lung cancer candidates for lung biopsy (n = 3). Illumina high‐throughput (HiSeq 2000) sequencing was performed to identify known and novel miRNAs differentially expressed in the blood and BALFs of ARDS patients compared with controls. …”
Publicado 2022
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134079por Gui, Xianhua, Li, Wangzhong, Yu, Yanzhe, Zhao, Tingting, Jin, Ziyi, Meng, Kaifang, Wang, Rujia, Shi, Shenyun, Yu, Min, Ma, Miao, Chen, Lulu, Luan, Wei, Xin, Xiaoyan, Qiu, Yuying, Qiu, Xiaohua, Zhang, Yingwei, Cao, Min, Cao, Mengshu, Dai, Jinghong, Cai, Hourong, Huang, Mei, Xiao, Yonglong“…METHODS: This prognostic study included Asian patients with anti-MDA5 DM-ILD hospitalized at the Nanjing Drum Hospital from December 2016 to December 2020. Candidate laboratory indicators were retrospectively collected. …”
Publicado 2022
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134080“…Prostate and Cervical Cancer were covered. A number of 245 candidates completed the pre-program online registration (RO- 83, MP-43, RTT-87 and PG Students-32). …”
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