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  1. 134181
    “…METHODS: In the present study, we analysed the MA applications (MAAs) of all 33 mAbs and three fusion proteins evaluated by the European Medicines Agency (EMA) between July 2012 and November 2022 with special emphasis on all submitted rituximab (four products) and trastuzumab (seven products) biosimilar candidates, including withdrawn applications. For the two withdrawn applications, the comparative efficacy trials suggested biosimilarity, but the quality/CMC package was not accepted by EMA. …”
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    Do the Outcomes of Clinical Efficacy Trials Matter in Regulatory Decision-Making for Biosimilars?
  2. 134182
    “…The identified B vitamin metabolomic biomarkers were then used in epigenome-wide association tests with fasting blood DNA methylation levels at 430,768 sites from the Infinium HumanMethylation450 BeadChip in blood samples from 2182 European participants from the TwinsUK and KORA cohorts. Candidate signals were explored for metabolite associations with gene expression levels in a subset of the TwinsUK sample (n = 297). …”
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    Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
  3. 134183
    “…CONCLUSIONS: This study suggests that CAF-FA-CS-NPs (D4) in combination with MTX may be a promising candidate for cancer immunotherapy, by inhibiting A2aR signaling and leading to improved immune activation and anti-tumor activity of MTX.…”
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    Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade
  4. 134184
    “…While S. cerevisiae is the most extensively studied model yeast, the oleaginous yeast Yarrowia lipolytica has emerged as a promising candidate for the synthesis of valuable products. In this study, we explored the potential of Y. lipolytica as a host for producing MAAs, utilizing its advantages such as a robust pentose phosphate pathway flux and versatile carbon source utilization. …”
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    Efficient production of mycosporine-like amino acids, natural sunscreens, in Yarrowia lipolytica
  5. 134185
    por Troeman, Darren P. R., Hazard, Derek, Timbermont, Leen, Malhotra-Kumar, Surbhi, van Werkhoven, Cornelis H., Wolkewitz, Martin, Ruzin, Alexey, Goossens, Herman, Bonten, Marc J. M., Harbarth, Stephan, Sifakis, Frangiscos, Kluytmans, Jan A. J. W., Vlaeminck, Jelle, Vilken, Tuba, Xavier, Basil Britto, Lammens, Christine, van Esschoten, Marjolein, Paling, Fleur P., Recanatini, Claudia, Coenjaerts, Frank, Sellman, Bret, Tkaczyk, Christine, Weber, Susanne, Ekkelenkamp, Miquel Bart, van der Laan, Lijckle, Vierhout, Bastiaan P., Couvé-Deacon, Elodie, David, Miruna, Chadwick, David, Llewelyn, Martin J., Ustianowski, Andrew, Bateman, Antony, Mawer, Damian, Carevic, Biljana, Konstantinovic, Sonja, Djordjevic, Zorana, del Toro-López, María Dolores, Gallego, Juan Pablo Horcajada, Escudero, Dolores, Rojo, Miquel Pujol, Torre-Cisneros, Julian, Castelli, Francesco, Nardi, Giuseppe, Barbadoro, Pamela, Altmets, Mait, Mitt, Piret, Todor, Adrian, Bubenek-Turconi, Serban-Ion, Corneci, Dan, Săndesc, Dorel, Gheorghita, Valeriu, Brat, Radim, Hanke, Ivo, Neumann, Jan, Tomáš, Tomáš, Laffut, Wim, Van den Abeele, Anne-Marie
    Publicado 2023
    “…The independent association of candidate variables was estimated using multivariable Cox proportional hazards regression models. …”
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    Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization
  6. 134186
    “…CONCLUSION: Our study demonstrated that (177)Lu-PDA-CS-MgO microsphere hold great potential as interventional brachytherapy candidate for HCC therapy. GRAPHICAL ABSTRACT: Polymer composite microspheres loading (177)Lu radionuclide and MgO nanoparticles for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer. …”
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    Polymer composite microspheres loading (177)Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer
  7. 134187
    “…Histone variant macroH2A1.1 is a candidate epigenetic mechanism linking environmental and dietary factors to obesity. …”
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    Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice
  8. 134188
    “…For the X-ray images of 204 patients with idiopathic scoliosis who underwent full-spine radiography, histogram equalization of original image was performed before a flipping method was used to magnify asymmetric elements, search for the global maximum pixel value in each line, and scan local maximal pixel value, with the intersection set of two point sets being regarded as candidate anchor points. All fine anchors were fitted with cubic spline algorithm to obtain the approximate curve of the spine, and the degree of scoliosis was measured by the standardized integral area. …”
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    Application of machine learning standardized integral area algorithm in measuring the scoliosis
  9. 134189
    “…CONCLUSIONS: SU11248 is a potential candidate drug for the treatment of AE, which predominantly inhibits parasite-induced angiogenesis. …”
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    Effect of sunitinib against Echinococcus multilocularis through inhibition of VEGFA-induced angiogenesis
  10. 134190
    “…Moreover, the complementary use of our 11 genes predictor with p16/KI67 evaluation could represent a prompt tool for recognizing the intrinsically CDK4/6i insensitive patients, who are potentially better candidates to immediate chemotherapy.…”
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    CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas
  11. 134191
    “…These potential biomarker candidates were prioritized through a multi-stage biomarker discovery pipeline articulated in: discovery, LC-PRM assay development and verification phases. …”
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    Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
  12. 134192
    “…It seems that structural amendment and stereoselective synthesis like adding sulphonate or sulphamate groups to these phytocompounds may make them more suitable candidates for considering in preclinical investigations of Alzheimer’s disease. …”
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    Chemo- and bio-informatics insight into anti-cholinesterase potentials of berries and leaves of Myrtus communis L., Myrtaceae: an in vitro/in silico study
  13. 134193
    “…Moreover, we identified EFEMP1, a secreted glycoprotein, as a metastatic driver and a potential candidate prognostic biomarker for lung metastasis in osteosarcoma patients. …”
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    Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
  14. 134194
    “…Public domain datasets were used to assess the clinical relevance of the candidate proteins. Cell-based and mouse models were used for biochemical and functional characterization of the protein molecule Sciellin (SCEL) identified by iTRAQ to elucidate its role and underlying mechanism in promoting lung colonization of TNBC cells. …”
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    SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
  15. 134195
    “…RESULTS: We identified a set of 29 candidate genes (i.e., putative AD genes) which could be differentially expressed in peripheral blood of patients with AD through the systematic search of publicly available datasets. …”
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    Aging gene signature of memory CD8(+) T cells is associated with neurocognitive functioning in Alzheimer’s disease
  16. 134196
    “…METHODS: The gene expression data (GSE23649) of m(6)A regulators in human liver tissue samples before cold perfusion and within 2 h after portal vein perfusion from Gene Expression Omnibus database was analyzed. The candidate m(6)A regulators were screened using random forest (RF) model to predict the risk of hepatic IRI. …”
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    Key m(6)A regulators mediated methylation modification pattern and immune infiltration characterization in hepatic ischemia-reperfusion injury
  17. 134197
    “…CONCLUSION: Ethiopian barley landraces are promising candidates for further yield improvement and conservation. …”
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    Phenotypic characterization and seed viability test in ex-situ conserved Ethiopian cultivated barley (Hordeum vulgare L.) landraces
  18. 134198
    “…Therefore, PvDBP is a leading vaccine candidate for P. vivax and a target for therapeutic human monoclonal antibodies (humAbs). …”
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    Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein
  19. 134199
    “…Considering the second-order Akaike Information Criterion consisting of likelihood ratio and number of parameters, miR-34b-5p showed the best discrimination power among the nine candidate miRNAs. A combined panel of miR-34b-5p and 194-5p was the best fit model to discriminate between MDA and control, revealing 100% sensitivity and specificity. …”
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    MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix
  20. 134200
    “…The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_AE viruses and the RV144 CRF01_AE immunogen. …”
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    Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization
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