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134201por Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V., Annesi-Maesano, Isabella, Antó, Josep M., Auffray, Charles, Ballereau, Stéphane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie-Aline, de Kluizenaar, Yvonne, den Dekker, Herman T., Duijts, Liesbeth, Felix, Janine F., Gehring, Ulrike, Guxens, Mònica, Jaddoe, Vincent V.W., Jankipersadsing, Soesma A., Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Rémy, Sunyer, Jordi, Söderhäll, Cilla, Yao, Jin, London, Stephanie J., Pershagen, Göran, Koppelman, Gerard H., Melén, Erik“…Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. …”
Publicado 2016
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134202por Requena, Pilar, Arévalo-Herrera, Myriam, Menegon, Michela, Martínez-Espinosa, Flor E., Padilla, Norma, Bôtto-Menezes, Camila, Malheiro, Adriana, Hans, Dhiraj, Castellanos, Maria Eugenia, Robinson, Leanne, Samol, Paula, Kochar, Swati, Kochar, Sanjay K., Kochar, Dhanpat K., Desai, Meghna, Sanz, Sergi, Quintó, Llorenç, Mayor, Alfredo, Rogerson, Stephen, Mueller, Ivo, Severini, Carlo, del Portillo, Hernando A., Bardají, Azucena, Chitnis, Chetan C., Menéndez, Clara, Dobaño, Carlota“…We hypothesized that functional immune responses against putative targets of naturally acquired immunity to malaria and vaccine candidates will be associated with protection against malaria infection and/or poor outcomes during pregnancy. …”
Publicado 2017
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134203por Hill, Katherine E., Kelly, Andrew D., Kuijjer, Marieke L., Barry, William, Rattani, Ahmed, Garbutt, Cassandra C., Kissick, Haydn, Janeway, Katherine, Perez-Atayde, Antonio, Goldsmith, Jeffrey, Gebhardt, Mark C., Arredouani, Mohamed S., Cote, Greg, Hornicek, Francis, Choy, Edwin, Duan, Zhenfeng, Quackenbush, John, Haibe-Kains, Benjamin, Spentzos, Dimitrios“…We used time-dependent receiver operating characteristic (tdROC) analysis to evaluate the clinical value of candidate miRNA profiles and machine learning approaches to compare the coding and non-coding transcriptional programs of high- and low-risk osteosarcoma tumors and high- versus low-aggressiveness cell lines. …”
Publicado 2017
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134204por Le Pogam, Marie-Annick, Quantin, Catherine, Reich, Oliver, Tuppin, Philippe, Fagot-Campagna, Anne, Paccaud, Fred, Peytremann-Bridevaux, Isabelle, Burnand, Bernard“…The GPSI and GQI development and validation process will comprise 6 stages: (1) selection and specification of candidate indicators, (2) definition of administrative data-based algorithms, (3) empirical measurement of indicators using linked administrative health data, (4) validation of indicators, (5) analyses of geographic and temporal variations for reliable and valid indicators, and (6) data visualization. …”
Publicado 2017
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134205por Drakeley, Chris, Abdulla, Salim, Agnandji, Selidji Todagbe, Fernandes, José Francisco, Kremsner, Peter, Lell, Bertrand, Mewono, Ludovic, Bache, Bache Emmanuel, Mihayo, Michael Gabriel, Juma, Omar, Tanner, Marcel, Tahita, Marc Christian, Tinto, Halidou, Diallo, Salou, Lompo, Palpouguini, D’Alessandro, Umberto, Ogutu, Bernhards, Otieno, Lucas, Otieno, Solomon, Otieno, Walter, Oyieko, Janet, Asante, Kwaku Poku, Dery, Dominic Bon-Ereme, Adjei, George, Adeniji, Elisha, Atibilla, Dorcas, Owusu-Agyei, Seth, Greenwood, Brian, Gesase, Samwel, Lusingu, John, Mahende, Coline, Mongi, Robert, Segeja, Method, Adjei, Samuel, Agbenyega, Tsiri, Agyekum, Alex, Ansong, Daniel, Bawa, John Tanko, Boateng, Harry Owusu, Dandalo, Léonard, Escamilla, Veronica, Hoffman, Irving, Maenje, Peter, Martinson, Francis, Carter, Terrell, Leboulleux, Didier, Kaslow, David C., Usuf, Effua, Pirçon, Jean-Yves, Bahmanyar, Edith Roset“…This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over ≤ 4 standardized cross-sectional surveys. …”
Publicado 2017
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134206por Weber-Lassalle, Nana, Hauke, Jan, Ramser, Juliane, Richters, Lisa, Groß, Eva, Blümcke, Britta, Gehrig, Andrea, Kahlert, Anne-Karin, Müller, Clemens R., Hackmann, Karl, Honisch, Ellen, Weber-Lassalle, Konstantin, Niederacher, Dieter, Borde, Julika, Thiele, Holger, Ernst, Corinna, Altmüller, Janine, Neidhardt, Guido, Nürnberg, Peter, Klaschik, Kristina, Schroeder, Christopher, Platzer, Konrad, Volk, Alexander E., Wang-Gohrke, Shan, Just, Walter, Auber, Bernd, Kubisch, Christian, Schmidt, Gunnar, Horvath, Judit, Wappenschmidt, Barbara, Engel, Christoph, Arnold, Norbert, Dworniczak, Bernd, Rhiem, Kerstin, Meindl, Alfons, Schmutzler, Rita K., Hahnen, Eric“…CONCLUSIONS: To avoid ambiguous results, studies aimed at assessing the impact of candidate predisposition gene mutations on BC risk might differentiate between BC index patients with an OC family history and those without. …”
Publicado 2018
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134207por Ashraf, Yahya, Mansouri, Hanane, Laurent-Matha, Valérie, Alcaraz, Lindsay B., Roger, Pascal, Guiu, Séverine, Derocq, Danielle, Robin, Gautier, Michaud, Henri-Alexandre, Delpech, Helène, Jarlier, Marta, Pugnière, Martine, Robert, Bruno, Puel, Anthony, Martin, Lucie, Landomiel, Flavie, Bourquard, Thomas, Achour, Oussama, Fruitier-Arnaudin, Ingrid, Pichard, Alexandre, Deshayes, Emmanuel, Turtoi, Andrei, Poupon, Anne, Simony-Lafontaine, Joëlle, Boissière-Michot, Florence, Pirot, Nelly, Bernex, Florence, Jacot, William, du Manoir, Stanislas, Theillet, Charles, Pouget, Jean-Pierre, Navarro-Teulon, Isabelle, Bonnefoy, Nathalie, Pèlegrin, André, Chardès, Thierry, Martineau, Pierre, Liaudet-Coopman, Emmanuelle“…The Fc function of F1, the best antibody candidate, was essential for maximal tumor inhibition in the MDA-MB-231 model. …”
Publicado 2019
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134208por Stemmer, Salomon M., Steiner, Mariana, Rizel, Shulamith, Ben-Baruch, Noa, Uziely, Beatrice, Jakubowski, Debbie M., Baron, Julie, Shak, Steven, Soussan-Gutman, Lior, Bareket-Samish, Avital, Fried, Georgeta, Rosengarten, Ora, Itay, Amit, Nisenbaum, Bella, Katz, Daniela, Leviov, Michelle, Tokar, Margarita, Liebermann, Nicky, Geffen, David B.“…Patients with RS 26–100 had high distant recurrence risk despite CT use and are candidates for new treatment approaches.…”
Publicado 2019
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134209por Shaw, Stephen M., Middleton, Jenny, Wigglesworth, Kim, Charlemagne, Amber, Schulz, Oliver, Glossop, Melanie S., Whalen, Giles F., Old, Robert, Westby, Mike, Pickford, Chris, Tabakman, Rinat, Carmi-Levy, Irit, Vainstein, Abi, Sorani, Ella, Zur, Arik A., Kristian, Sascha A.“…CONCLUSIONS: We have identified AGI-134 as an immunotherapeutic drug candidate, which could be an excellent combination partner for anti-PD-1 therapy, by facilitating tumor antigen processing and increasing the repertoire of tumor-specific T cells prior to anti-PD-1 treatment.…”
Publicado 2019
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134210“…Computer-aided research on the relationship between molecular structures of natural compounds (NC) and their biological activities have been carried out extensively because the molecular structures of new drug candidates are usually analogous to or derived from the molecular structures of NC. …”
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134211por Sun, Shi-Chao, Xiong, Xian-Peng, Zhang, Xiao-Li, Feng, Hong-Jie, Zhu, Qian-Hao, Sun, Jie, Li, Yan-Jun“…Taken together, these results demonstrated that Gh4CL7 could positively respond to drought stress and therefore might be a candidate gene for improvement of drought tolerance in cotton. …”
Publicado 2020
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134212por Xu, Jianye, Zhang, Zongpu, Qian, Mingyu, Wang, Shaobo, Qiu, Wei, Chen, Zihang, Sun, Zhongzheng, Xiong, Ye, Wang, Chaochao, Sun, Xiaopeng, Zhao, Rongrong, Xue, Hao, Li, Gang“…Furthermore, CUL7 might be a candidate molecular target for the treatment of glioma.…”
Publicado 2020
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134213por Zhang, Zi-jia, Wu, Wen-yong, Hou, Jin-jun, Zhang, Lin-lin, Li, Fei-fei, Gao, Lei, Wu, Xing-dong, Shi, Jing-ying, Zhang, Rong, Long, Hua-li, Lei, Min, Wu, Wan-ying, Guo, De-an, Chen, Kai-xian, Hofmann, Lewis A., Ci, Zhong-hua“…One-hundred and eighteen candidate constituents showed a high binding affinity with SARS-coronavirus-2 3-chymotrypsin-like protease (3CL(pro)), as indicated by molecular docking using computational pattern recognition. …”
Publicado 2020
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134214por Li, Yu-an, Chen, Yunyun, Du, Yuan zhao, Guo, Weiwei, Chu, Dianfeng, Fan, Juan, Wang, Xiaobo, Bellefleur, Matthew, Wang, Shifeng, Shi, Huoying“…Choleraesuis vaccine candidate strain rSC0011 (ΔP(crp527)::TT araC P(BAD)crp Δpmi-2426 ΔrelA199::araC P(BAD)lacI TT ΔasdA33, Δ, deletion, TT, terminator) delivering SaoA, a conserved surface protein in most of S. suis serotypes, provided excellent protection against S. suis challenge, but occasionally lead to morbidity (enteritidis) in vaccinated mice (approximately 1 in every 10 mice). …”
Publicado 2020
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134215por Wu, Huizhe, Qin, Wenyan, Lu, Senxu, Wang, Xiufang, Zhang, Jing, Sun, Tong, Hu, Xiaoyun, Li, Yalun, Chen, Qiuchen, Wang, Yuanhe, Zhao, Haishan, Piao, Haiyan, Zhang, Rui, Wei, Minjie“…METHODS: The dysregulated expression profiling of lncRNAs-snoRNAs-mRNAs and their correlations and co-expression enrichment were assessed by GeneChip microarray analysis. The candidate lncRNAs, snoRNAs, and target genes were detected by in situ hybridization (ISH), RT-PCR, qPCR and immunofluorescence (IF) assays. …”
Publicado 2020
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134216por He, Jia, Yuan, Renyikun, Cui, Xiaolan, Cui, Yushun, Han, Shan, Wang, Qin-Qin, Chen, Yangling, Huang, Liting, Yang, Shilin, Xu, Qiongming, Zhao, Yonghui, Gao, Hongwei“…CONCLUSION: Our findings demonstrated that anemoside B4 attenuates pneumonia via the TLR4/Myd88 signaling pathway, suggesting that anemoside B4 is a promising therapeutic candidate for bacterial-infected or viral-infected pneumonia.…”
Publicado 2020
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134217por Matsuyama, Hideyasu, Matsubara, Nobuaki, Kazama, Hirotaka, Seto, Takeshi, Tsukube, Shoko, Suzuki, Kazuhiro“…Some patients at high risk of ADRs or unfit patients may benefit from a lower starting dose of 20 mg/m(2), whereas fit patients may be candidates for a starting dose of 25 mg/m(2). TRIAL REGISTRATION: Not applicable.…”
Publicado 2020
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134218por Boonyalai, Nonlawat, Vesely, Brian A., Thamnurak, Chatchadaporn, Praditpol, Chantida, Fagnark, Watcharintorn, Kirativanich, Kirakarn, Saingam, Piyaporn, Chaisatit, Chaiyaporn, Lertsethtakarn, Paphavee, Gosi, Panita, Kuntawunginn, Worachet, Vanachayangkul, Pattaraporn, Spring, Michele D., Fukuda, Mark M., Lon, Chanthap, Smith, Philip L., Waters, Norman C., Saunders, David L., Wojnarski, Mariusz“…The use of latest field isolates may be necessary for assessment of relevant drug combinations against P. falciparum strains and when down-selecting novel drug candidates.…”
Publicado 2020
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134219por Poran, Asaf, Harjanto, Dewi, Malloy, Matthew, Arieta, Christina M., Rothenberg, Daniel A., Lenkala, Divya, van Buuren, Marit M., Addona, Terri A., Rooney, Michael S., Srinivasan, Lakshmi, Gaynor, Richard B.“…We then utilized our HLA-I and HLA-II predictors to identify 11,897 HLA-I and 8046 HLA-II candidate peptides which were highly ranked for binding across 13 open reading frames (ORFs) of SARS-CoV-2. …”
Publicado 2020
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134220por Huang, Wei-Chiao, Deng, Bingbing, Mabrouk, Moustafa T., Seffouh, Amal, Ortega, Joaquin, Long, Carole, Miura, Kazutoyo, Wu, Yimin, Lovell, Jonathan F.“…BACKGROUND: The Plasmodium falciparum sexual-stage surface proteins Pfs25 and Pfs230 are antigen candidates for a malaria transmission-blocking vaccine (TBV), and have been widely investigated as such. …”
Publicado 2020
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