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  1. 134301
    “…RESULTS: Four upregulated candidate DEMs (hsa-miR199a-5p, hsa-miR-186-5p, hsa-miR-328-3p, and hsa-let-7d-3p) were screened from 3 databases, and 6 upstream transcription factors and 2253 downstream target genes were predicted. …”
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    Using biological information to analyze potential miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer
  2. 134302
    “…As the expression profile of CD22 is similar to that of CD19, CD22 has become a candidate target when CD19 CAR-T therapy fails. METHODS: A novel CD22 CAR incorporating scFv derived from an HIB22 hybridoma which bound the first and second Ig-like extracellular domains of CD22 antigen was constructed. …”
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    A novel and efficient CD22 CAR-T therapy induced a robust antitumor effect in relapsed/refractory leukemia patients when combined with CD19 CAR-T treatment as a sequential therapy
  3. 134303
    “…Considering that the paleoclimate oscillation and the development of an eastward-flowing drainage system during the Pliocene and Pleistocene in China provided an opportunity for hybridization between divergent lineages, the formation of 2nNCRC in our laboratory could be a good candidate for explaining the HHS of C. auratus in nature. …”
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    Phylogeographic relationships and the evolutionary history of the Carassius auratus complex with a newly born homodiploid raw fish (2nNCRC)
  4. 134304
    “…Our engineered exosomes are a promising candidate for tissue-engineered ear cartilage regeneration. …”
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    Online Artículo Texto
    Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes and tissue-engineered ear cartilage regeneration
  5. 134305
    “…METHODS: RNA sequencing and quantitative real-time PCR (qRT-PCR) assays were applied to screen for circRNAs differentially expressed in LSCC tissues and cell lines. The candidate RNA-binding proteins and target signalling pathway were detected by RNA pull-down and mass spectrometry, in situ hybridization (ISH), immunohistochemistry (IHC), qRT-PCR assays, and bioinformatics analysis. …”
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    Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation
  6. 134306
    “…METHODS: The study was conducted in three stages: (1) model development, (2) prospective validation of the model with new data, and (3) a clinical assessment with a pilot study that included the model as a stratification tool to select the patients in the intervention. Candidate models were built using retrospective data from appointments scheduled between January 1, 2015, and November 30, 2018, in the dermatology and pneumology outpatient services of the Hospital Municipal de Badalona (Spain). …”
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    Reducing non-attendance in outpatient appointments: predictive model development, validation, and clinical assessment
  7. 134307
    “…CONCLUSION: Our findings demonstrate that hY4F acts as a tumor suppressor and is selectively sorted into lung cancer cell-derived EVs by interacting with methylated YBX1, which in turn promotes lung cancer progression. hY4F is a promising circulating biomarker for non-small cell lung cancer diagnosis and prognosis and an exceptional candidate for further therapeutic exploration. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-022-02346-w.…”
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    Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression
  8. 134308
    “…BACKGROUND: We compared the oncological outcomes of patients who received seed brachytherapy (SEED-BT) with those who received radical prostatectomy (RP) for intermediate-risk prostate cancer. METHODS: Candidates were patients treated with either SEED-BT (n = 933) or RP (n = 334). …”
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    Direct comparison of low-dose-rate brachytherapy versus radical prostatectomy using the surgical definition of biochemical recurrence for patients with intermediate-risk prostate cancer
  9. 134309
    “…In addition to its high subgroup specificity, CYB5Aalt is a novel candidate to be potentially implicated in therapy resistance in NH and HeH BCP-ALL. …”
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    An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse
  10. 134310
    “…METHODS: By analyzing TCGA data, 344 candidate markers with 424 primer pairs and probe sets synthesized were systematically screened in cancer cell lines, paired tissue specimens, and urine sediments from bladder cancer patients and normal controls. …”
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    A novel and sensitive DNA methylation marker for the urine-based liquid biopsies to detect bladder cancer
  11. 134311
    “…The CCAE model was identified as a candidate for clinical use. The use case demonstrates that IPEV provides a huge opportunity in a new era of standardised data and analytics to improve insight into and trust in prediction models at an unprecedented scale. …”
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    Using Iterative Pairwise External Validation to Contextualize Prediction Model Performance: A Use Case Predicting 1-Year Heart Failure Risk in Patients with Diabetes Across Five Data Sources
  12. 134312
    “…We performed logistic regression with backward stepwise selection to develop a 100-predictor base model using 854 EHR candidate variables, including demographics, laboratory values, medications, healthcare utilization, diagnosis codes, and vitals. …”
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    Do functional status and Medicare claims data improve the predictive accuracy of an electronic health record mortality index? Findings from a national Veterans Affairs cohort
  13. 134313
    “…Collectively, PGA/Alum adjuvanted flu vaccine may be a promising vaccine candidate for the elderly. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12979-022-00282-z.…”
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    Poly-γ-glutamic acid/Alum adjuvanted pH1N1 vaccine-immunized aged mice exhibit a significant increase in vaccine efficacy with a decrease in age-associated CD8(+) T cell proportion in splenocytes
  14. 134314
    “…CONCLUSIONS: Plasma, but not urinary iFABP is a candidate biomarker with better fidelity in monitoring compliance during GFD than TGA. …”
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    Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease and Crohn’s disease
  15. 134315
    “…CONCLUSIONS: CSF could be a potential candidate for the genetic profiling of LM-LUAD, demonstrating the genetic characteristics of LM in EGFR-mutated lung adenocarcinoma on diverse EGFR-TKI therapies.…”
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    Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of lung adenocarcinoma using next-generation sequencing
  16. 134316
    “…Among individuals without diabetes, Cox proportional hazards regression models (both age- and sex-adjusted, and then multivariable-adjusted for all candidate predictors) identified predictors of incident diabetes over a decade of follow-up, defined using clinical history or laboratory assessments. …”
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    Predictors of incident diabetes in two populations: framingham heart study and hispanic community health study / study of latinos
  17. 134317
    por van der Ende, Emma L, Bron, Esther E, Poos, Jackie M, Jiskoot, Lize C, Panman, Jessica L, Papma, Janne M, Meeter, Lieke H, Dopper, Elise G P, Wilke, Carlo, Synofzik, Matthis, Heller, Carolin, Swift, Imogen J, Sogorb-Esteve, Aitana, Bouzigues, Arabella, Borroni, Barbara, Sanchez-Valle, Raquel, Moreno, Fermin, Graff, Caroline, Laforce, Robert, Galimberti, Daniela, Masellis, Mario, Tartaglia, Maria Carmela, Finger, Elizabeth, Vandenberghe, Rik, Rowe, James B, de Mendonça, Alexandre, Tagliavini, Fabrizio, Santana, Isabel, Ducharme, Simon, Butler, Christopher R, Gerhard, Alexander, Levin, Johannes, Danek, Adrian, Otto, Markus, Pijnenburg, Yolande A L, Sorbi, Sandro, Zetterberg, Henrik, Niessen, Wiro J, Rohrer, Jonathan D, Klein, Stefan, van Swieten, John C, Venkatraghavan, Vikram, Seelaar, Harro
    Publicado 2021
    “…Further research should investigate their utility as candidate selection tools for pharmaceutical trials. …”
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    A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia
  18. 134318
    “…The screen revealed four-candidate type II MET-TKIs (altiratinib, CEP-40783, foretinib and sitravatinib). …”
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    Foretinib can overcome common on-target resistance mutations after capmatinib/tepotinib treatment in NSCLCs with MET exon 14 skipping mutation
  19. 134319
    “…Hence, TL8-506-based combinations may be promising candidates to initiate or boost antitumor responses in patients with cancer.…”
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    Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
  20. 134320
    “…Specifically, ERS protein, mesencephalic astrocyte-derived neurotrophic factor (MANF), was elevated following calcium depletion, making it a potential biomarker candidate for human samples. Despite no significant elevation of MANF in plasma levels among healthy volunteers and RYR1-RM individuals, MANF plasma levels positively correlated with age in RYR1-RM individuals, presenting a potential biomarker of disease progression. …”
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    Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells
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