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  1. 134381
    “…CONCLUSIONS: The correlation between the echocardiographic diastolic filling parameters and diastolic signals detected by the accelerometer of the MICRA AV is poor, so it seems to be as poor guidance to select proper candidates for MICRA AV. [Figure: see text] [Figure: see text]…”
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    Clinical and echocardiographic predictors of atrioventricular synchrony provided by leadless pacemakers: results from the OptiVALL study
  2. 134382
    “…Additionally, this prediction rule, based on its association with arrhythmogenic potentials, may be able to predict which ambulatory patients who have not had manifest VT, may be prone to develop VT thus help identify early VT ablation candidates. This concept should be validated in larger data sets and is ideal for training and testing using surface ECG envelopes with artificial intelligence algorithms. …”
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    A method to identify which patients will have VT substrate ablation targets prior to ablation procedure
  3. 134383
    “…These individuals are potential candidates for tailored outreach to improve adherence to recommended annual lung cancer screening.…”
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    Factors Associated With Nonadherence to Lung Cancer Screening Across Multiple Screening Time Points
  4. 134384
    “…Before the pandemic, treatment with the gait device had been provided in person to appropriate candidates using a combination of physical therapists and trained personnel. …”
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    Gait Device Treatment Using Telehealth for Individuals With Stroke During the COVID-19 Pandemic: Nonrandomized Pilot Feasibility Study
  5. 134385
    “…Pan-cancer and multi-omics analysis in adults with ACC, in order to classify the candidates for immunotherapy, had heterogeneous results, and integrating an MMR system in this larger and challenging picture is still an open issue. …”
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    Pathogenic Insights into DNA Mismatch Repair (MMR) Genes–Proteins and Microsatellite Instability: Focus on Adrenocortical Carcinoma and Beyond
  6. 134386
    “…We measured the diagnostic accuracy of seven candidate RNA biomarkers for the reference standard of Mycobacterium tuberculosis culture status, using area under the receiver-operating characteristic curve (AUROC) analysis, and sensitivity/specificity at pre-specified thresholds (two standard scores above the mean of healthy controls; Z2). …”
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    Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy study
  7. 134387
    “…Therefore, [(225)Ac]Ac-DOTA-JR11 can be a potential candidate to improve the treatment of NETs (Graphical abstract). …”
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    First preclinical evaluation of [(225)Ac]Ac-DOTA-JR11 and comparison with [(177)Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
  8. 134388
    “…We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age indicators, to child developmental outcomes, including growth and adiposity, cognition, behavior, lung function and the onset of puberty, among European school-age children participating in the HELIX exposome cohort. …”
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    Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort
  9. 134389
    “…Network pharmacology outcomes showed the MAPK and PI3K-AKT signaling pathways are closely associated with 10 hub genes (especially AKT1), and AKT/GSK-3β/β-catenin was selected as the candidate analysis pathway. In hMSCs and C3H10 cells, results showed that EN at appropriate concentrations of 0.008–5 μM effectively increased the cell proliferation. …”
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    Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling
  10. 134390
    por Seaton, Kelly E., Huang, Yunda, Karuna, Shelly, Heptinstall, Jack R., Brackett, Caroline, Chiong, Kelvin, Zhang, Lily, Yates, Nicole L., Sampson, Mark, Rudnicki, Erika, Juraska, Michal, deCamp, Allan C., Edlefsen, Paul T., Mullins, James I., Williamson, Carolyn, Rossenkhan, Raabya, Giorgi, Elena E., Kenny, Avi, Angier, Heather, Randhawa, April, Weiner, Joshua A., Rojas, Michelle, Sarzotti-Kelsoe, Marcella, Zhang, Lu, Sawant, Sheetal, Ackerman, Margaret E., McDermott, Adrian B., Mascola, John R., Hural, John, McElrath, M. Julianna, Andrew, Philip, Hidalgo, Jose A., Clark, Jesse, Laher, Fatima, Orrell, Catherine, Frank, Ian, Gonzales, Pedro, Edupuganti, Srilatha, Mgodi, Nyaradzo, Corey, Lawrence, Morris, Lynn, Montefiori, David, Cohen, Myron S., Gilbert, Peter B., Tomaras, Georgia D.
    Publicado 2023
    “…To inform future study design and dosing regimen selection of candidate bnAbs, we investigated the association of VRC01 serum concentration with HIV-1 acquisition using AMP trial data. …”
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    Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition
  11. 134391
    “…While current studies do not unanimously agree on each QoL domain, the assessment of QoL might represent a supplementary argument to consider when deciding for PTx, especially in asymptomatic cases and in patients who do not fit into well-known categories of surgery candidates, according to current guidelines, thus assessing QoL in PHP is part of a current research gap. …”
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    Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism
  12. 134392
    “…Comparatively, the high-dose nanoemulsion exerted the most pronounced effect in improving PD in rats and may be a promising candidate for the development of health food or botanic drug.…”
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    Analysis of bioactive compounds in cinnamon leaves and preparation of nanoemulsion and byproducts for improving Parkinson’s disease in rats
  13. 134393
    “…BACKGROUND: Two autoimmune biologics were recently approved by the FDA: ustekinumab in September 2009 for the treatment of moderate to severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy and tocilizumab in January 2010 for adult patients with moderate to severe rheumatoid arthritis (RA) who have not responded adequately to 1 or more tumor necrosis factor (TNF) antagonist therapies. …”
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    Formulary Review of 2 New Biologic Agents: Tocilizumab for Rheumatoid Arthritis and Ustekinumab for Plaque Psoriasis
  14. 134394
    por Fairman, Kathleen A.
    Publicado 2007
    “…As filing deadlines approach, candidates don't know where to collect the signatures and donations they need to run for office. 4 The Mars Polar Explorer was launched in January 1999 to find evidence of precipitation on Mars, but it crashed into the planets' surface upon arriving on December 3, 1999. …”
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    Peeking Inside the Statistical Black Box: How to Analyze Quantitative Information and Get It Right the First Time
  15. 134395
    “…CONCLUSIONS: High p-mTOR expression predicts and high p-ERK expression tends to predict worse treatment outcome in HPV negative HNSCC patients treated with chemoradiation, providing additional evidence that these markers are candidate prognostic biomarkers for survival in this patient population. …”
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    p-mTOR, p-ERK and PTEN Expression in Tumor Biopsies and Organoids as Predictive Biomarkers for Patients with HPV Negative Head and Neck Cancer
  16. 134396
    “…CONCLUSION: Vobra duo exerts relevant antitumor activity in preclinical B7-H3-expressing NB models and represents a potential candidate for clinical translation.…”
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    Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma
  17. 134397
    “…Further localization studies ((99m)Tc Sestamibi parathyroid scintigraphy and 4D-CT of the neck) did not reveal any other possible candidates for parathyroid adenomas. Eventually, a fine needle aspiration of the nodule in the right thyroid lobe was performed. …”
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    FRI691 Intrathyroidal Parathyroid Adenoma With Congenitally Absent Contralateral Thyroid Lobe Treated With Thermal Ablation
  18. 134398
    “…We also studied Caucasian subjects (n=792) from the Hypertensive Pathotype (HyperPATH) cohort using the Multi-Ethnic Genotyping Array on the Illumina platform. Candidate gene association analyses showed that the single nucleotide polymorphic (SNP) Raptor gene variant, rs99001846, was associated with BP and ALDO levels. …”
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    FRI141 Dietary Salt Regulates mTORC1 Signaling In Humans And Mice With Hypertension
  19. 134399
    “…Since the patient was a poor surgical candidate, medical therapy was initiated with ketoconazole 200mg TID, aldactone 50mg BID and potassium chloride 40mEq TID. …”
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    THU577 Acth Dependent Cushing Syndrome Identification And Management Challenges
  20. 134400
    “…Adhesion G-protein Coupled Receptor L1 (Adgrl1) was a top candidate as a potential glucoreceptor. Therefore, we generated Adgrl1(loxp/loxp) mice to knockout Adgrl1 in the ventromedial hypothalamus (VMH; a region known for glucose sensing) using the Cre-Lox system to determine the role of Adgrl1(VMH) in glucose homeostasis, energy balance, and leptin sensitivity. …”
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    OR12-06 Hypothalamic Adgrl1 Is A Potential Glucoreceptor Involved In Regulating Energy Balance, Glucose Homeostasis, And Leptin Sensitivity In Mice
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