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  1. 134401
    “…Single-cell RNA sequencing (scRNA-seq) analysis was conducted through the Tumour Immune Single-cell Hub (TISCH) database, and the XSum algorithm was used to screen candidate small molecule drugs based on the Connectivity Map (CMAP) database. …”
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    Proposing a novel molecular subtyping scheme for predicting distant recurrence-free survival in breast cancer post-neoadjuvant chemotherapy with close correlation to metabolism and senescence
  2. 134402
    “…BACKGROUND: BK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic oligodeoxynucleotides bearing CpG motifs. …”
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    Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial
  3. 134403
    “…Our primary outcomes are establishing parameters of feasibility, acceptability, usability, and safety of this digital workplace health intervention. We will assess the candidate primary and secondary outcomes’ feasibility and test research processes for a definitive trial. …”
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    The Web-Based Pain-at-Work Toolkit With Telephone Support for Employees With Chronic or Persistent Pain: Protocol for a Cluster Randomized Feasibility Trial
  4. 134404
    “…Further experimental in vivo investigations of these candidate PACs, for treatment of high inoculum DNS MRSA infections (e.g., infective endocarditis) is warranted. …”
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    2066. Synergistic Bacteriophage-Antibiotic Combinations Against High Inoculum DNS MRSA
  5. 134405
    “…RESULTS: CD388-IA and -IS at comparable drug to antibody ratios (DARs) of 4.5±0.5 (used in the clinical candidate) demonstrated comparable protection (Figure 1) and comparable dose-dependent viral burden and cytokine reduction in a lethal mouse model (Table 1). …”
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    2116. Efficacy of CD388, a Novel Drug Fc-Conjugate (DFC), is Driven by the Small Molecule Neuraminidase Inhibitor (NAI)
  6. 134406
    “….: Staff Chris Mason, Ph.D., Biotia: Board Member|Biotia: Stocks/Bonds Heather L. Wells, MPH, PhD Candidate, Biotia, Inc.: Employee David C. Danko, Ph.D., Biotia Inc: Stocks/Bonds Niamh B. …”
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    2835. Utilization of Clinical-Grade Metagenomics in Urinary Tract Infection Diagnostics: Improving High-Risk Patients’ Outcomes with a Genomic-Based Assay
  7. 134407
    “…MZA may thus be a lead candidate for the development of novel therapeutic agents for the modulation of TXB(2 )and O(2)(- )release in neuroinflammatory diseases. …”
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    Differential modulation of microglia superoxide anion and thromboxane B(2 )generation by the marine manzamines
  8. 134408
    “…Some results confirmed previously reported associations with candidate genes including variation in the lipoprotein lipase gene (LPL) and HDL-C and TG (rs7007797; P = 0.0005 for HDL-C and 0.002 for TG). …”
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    A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
  9. 134409
    “…CONCLUSION: In this comprehensive analysis covering 59 kb of the PRL locus and 210 kb of the PRLR locus, we found no significant association between common variation in these candidate genes and breast cancer risk or plasma PRL levels. …”
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    A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort
  10. 134410
    “…Therefore when considering only the tumour to blood ratios of the total absorbed dose, the data suggests that TFM would be the most suitable candidate. However, when corrected for equitoxic blood levels, doses to normal tissues for TFM were approximately twice the level of IgG, producing a two-fold increase in the overall tumour to normal tissue ratio. …”
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    Dosimetric evaluation and radioimmunotherapy of anti-tumour multivalent Fab́ fragments
  11. 134411
    “…However, since challenge-tested animals cannot be used as breeding candidates, within-family selection is not performed and only half of the genetic variation for IPN resistance is being exploited. …”
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    Confirmation and fine-mapping of a major QTL for resistance to infectious pancreatic necrosis in Atlantic salmon (Salmo salar): population-level associations between markers and trait
  12. 134412
    “…Mucins and GALNTs (N-acetylgalactosaminyltransferase) are interesting candidates for CRC genetic susceptibility and have not been previously evaluated. …”
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    Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins
  13. 134413
    “…Possibly only patients with localized small airway disease are good candidates for long-term NIV treatment. To confirm this and to see if better arterial blood gases also lead to better health related quality of life and longer survival, we have to study a larger population.…”
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    The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study
  14. 134414
    “…IMD-0354 and its prodrug IMD-1041 seem to be promising candidates for treating intraocular inflammation/uveitis.…”
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    Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats
  15. 134415
    “…We apply PLSI to generate gapped-dipeptide signatures from both nuclear and non-nuclear proteins, and propose candidate sequence motifs for putative NLSs and NESs. …”
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    Prediction of nuclear proteins using nuclear translocation signals proposed by probabilistic latent semantic indexing
  16. 134416
    “…We tested the safety and immunogenicity of an oral adenovirus serotype 4 vector vaccine candidate (Ad4-H5-Vtn) expressing the haemagglutinin from an avian influenza A H5N1 virus. …”
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    Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study
  17. 134417
    “…The majority of PCs are organ-confined at diagnosis making them candidates for treatment using RAD, SURG, or other protocols. …”
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    Mining Surveillance Data: Does Radiation Treatment of Prostate Cancer Cause Rectal Cancer?
  18. 134418
    “…We added multiples of the standard deviation of each time series as single-day injects in separate algorithm runs. For each candidate method, we then used as a sensitivity measure the proportion of these runs for which the output of each algorithm was below alerting thresholds estimated empirically for each algorithm using simulated data streams. …”
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    Category-Specific Comparison of Univariate Alerting Methods for Biosurveillance Decision Support
  19. 134419
    “…ENDPOINT: First (ie, incident) emergency admission to hospital in the next 2 years as recorded on the linked hospital episodes records. RISK FACTORS: Candidate variables recorded on the general practitioner computer system including (1) demographic variables (age, sex, strategic health authority, Townsend deprivation score, ethnicity); (2) lifestyle variables (smoking, alcohol intake); (3) chronic diseases; (4) prescribed medication; (5) clinical values (body mass index, systolic blood pressure); (6) laboratory test results (haemoglobin, platelets, erythrocyte sedimentation rate, ratio of total serum cholesterol to high density lipoprotein cholesterol concentrations, liver function tests). …”
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    Predicting risk of emergency admission to hospital using primary care data: derivation and validation of QAdmissions score
  20. 134420
    “…We did whole-exome sequencing in affected individuals as they were enrolled, until we identified a candidate gene, and Sanger sequencing to confirm mutations. …”
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    The genetic basis of DOORS syndrome: an exome-sequencing study
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