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134481por Zhao, Shuang-Xia, Liu, Wei, Liang, Jun, Gao, Guan-Qi, Zhang, Xiao-Mei, Yao, Yu, Wang, Hai-Ning, Yuan, Fei-Fei, Xue, Li-Qiong, Ma, Yu-Ru, Zhang, Le-Le, Ye, Xiao-Ping, Zhang, Qian-Yue, Sun, Feng, Zhang, Rui-Jia, Yang, Shao-Ying, Zhan, Ming, Du, Wen-Hua, Liu, Bing-Li, Chen, Xia, Song, Zhi-Yi, Li, Xue-Song, Li, Ping, Ru, Ying, Zuo, Chun-Lin, Li, Sheng-Xian, Han, Bing, Zhu, Hui, Qiao, Jie, Xuan, Miao, Su, Bin, Sun, Fei, Ma, Jun-Hua, Chen, Jia-Lun, Tian, Hao-Ming, Chen, Sai-Juan, Song, Huai-Dong“…The prediction model using a weighted genetic risk score and 11 candidate TPP-specific single-nucleotide polymorphisms had an area under the curve of 0.80. …”
Publicado 2019
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134482por Al-Juboori, Shaymaa IK., Vadakekolathu, Jayakumar, Idri, Sarra, Wagner, Sarah, Zafeiris, Dimitrios, Pearson, Joshua RD., Almshayakhchi, Rukaia, Caraglia, Michele, Desiderio, Vincenzo, Miles, Amanda K., Boocock, David J., Ball, Graham R., Regad, Tarik“…BACKGROUND: Metformin, a biguanide, is one of the most commonly prescribed treatments for type 2 diabetes and has recently been recommended as a potential drug candidate for advanced cancer therapy. Although Metformin has antiproliferative and proapoptotic effects on breast cancer, the heterogenous nature of this disease affects the response to metformin leading to the activation of pro-invasive signalling pathways that are mediated by the focal adhesion kinase PYK2 in pure HER2 phenotype breast cancer. …”
Publicado 2019
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134483por Antony, Binu, Johny, Jibin, Abdelazim, Mahmoud M., Jakše, Jernej, Al-Saleh, Mohammed Ali, Pain, Arnab“…Furthermore, we used RNA interference to knock down the overexpressed P450s, after which a toxicity bioassay and quantitative expression analysis revealed likely candidates involved in metabolic resistance against imidacloprid in RPW. …”
Publicado 2019
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134484“…The patient was deemed a poor Neurosurgical candidate due to her age and comorbidities. She was started on Levothyroxine and Cabergoline. …”
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134485“…These finding may help us to sort which patients are better candidates for early definitive therapy.…”
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134486por de Jong, Wesley, Aerts, Joeri, Allard, Sabine, Brander, Christian, Buyze, Jozefien, Florence, Eric, van Gorp, Eric, Vanham, Guido, Leal, Lorna, Mothe, Beatriz, Thielemans, Kris, Plana, Montse, Garcia, Félipe, Gruters, Rob“…The trial extends on the safety results of a phase-I dose-escalating trial. This candidate vaccine could complement or even replace cART for chronic HIV infection and could be applicable to improve the care and cost of HIV infection. …”
Publicado 2019
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134487“…METHODS: All consecutive STEMI patients candidate for PPCI and admitted to Critical Care Department, Cairo University hospitals, managed either by thrombectomy before primary PCI (if thrombus score ≥ 3) or conventional PPCI, Six hundred seven subjects were enrolled in the study divided into Group with thrombectomy before PPCI (107 subjects, 18%), and group with Conventional PCI (500 subjects, 82%). …”
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134488por Schreiber, Sanja, Parent, Eric C., Hill, Doug L., Hedden, Douglas M., Moreau, Marc J., Southon, Sarah C.“…Participants with diagnoses other than AIS, surgical candidates or patients who had scoliosis surgery were excluded. …”
Publicado 2019
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134489por Longo, Jody Fromm, Brosius, Stephanie N., Black, Laurel, Worley, Stuart H., Wilson, Robert C., Roth, Kevin A., Carroll, Steven L.“…Although we have previously shown that broad-spectrum erbB inhibitors inhibit Ras activation, Erbb4 ablation did not affect Ras activation, suggesting that erbB4 drives neoplasia via non-Ras dependent pathways. An analysis of 43 candidate kinases identified multiple NRG1β-responsive and erbB4-dependent signaling cascades including the PI3K, WNK1, STAT3, STAT5 and phospholipase-Cγ pathways. …”
Publicado 2019
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134490Perioperative Complications During Living Donor Nephrectomy: Results From a Multicenter Cohort Studypor Garcia-Ochoa, Carlos, Feldman, Liane S., Nguan, Christopher, Monroy-Cuadros, Mauricio, Arnold, Jennifer, Boudville, Neil, Cuerden, Meaghan, Dipchand, Christine, Eng, Michael, Gill, John, Gourlay, William, Karpinski, Martin, Klarenbach, Scott, Knoll, Greg, Lentine, Krista L., Lok, Charmaine E., Luke, Patrick, Prasad, G. V. Ramesh, Sener, Alp, Sontrop, Jessica M., Storsley, Leroy, Treleaven, Darin, Garg, Amit X.“…RESULTS: Of the 1421 living kidney donor candidates, 1042 individuals proceeded with donation, where 134 (13% [95% confidence interval (CI): 11%-15%]) experienced 142 perioperative complications (55 intraoperative; 87 postoperative). …”
Publicado 2019
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134491por Chen, Er-Bao, Zhou, Zheng-Jun, Xiao, Kun, Zhu, Gui-Qi, Yang, Yi, Wang, Biao, Zhou, Shao-Lai, Chen, Qing, Yin, Dan, Wang, Zheng, Shi, Ying-Hong, Gao, Dong-Mei, Chen, Jie, Zhao, Yan, Wu, Wei-Zhong, Fan, Jia, Zhou, Jian, Dai, Zhi“…Chemokine expression profiling and bioinformatics were used to detect the downstream target of candidate target. In gain- and loss-of-function assays were used to investigate the role of miRNA in HCC progression. …”
Publicado 2019
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134492por Raavé, René, Sandker, Gerwin, Adumeau, Pierre, Jacobsen, Christian Borch, Mangin, Floriane, Meyer, Michel, Moreau, Mathieu, Bernhard, Claire, Da Costa, Laurène, Dubois, Adrien, Goncalves, Victor, Gustafsson, Magnus, Rijpkema, Mark, Boerman, Otto, Chambron, Jean-Claude, Heskamp, Sandra, Denat, Franck“…DFOcyclo* is a promising candidate to become the new clinically used standard chelator for (89)Zr immunoPET. …”
Publicado 2019
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134493“…Two common polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARG) gene, rs1801282 and rs3856806, may be important candidate gene loci affecting the susceptibility to ischemic stroke. …”
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134494“…Combining differential gene expression patterns with reported GO function terms and quantitative trait loci, a total of 27 top genes was selected as highly promising candidate genes for genetic resistance to MD. These genes are functionally involved with virus process (F13A1 and HSP90AB1), immunity (ABCB1LB, RGS5, C10ORF58, OSF-2, MMP7, CXCL12, GAL1, GAL2, GAL7, HVCN1, PDE4D, IL4I1, PARP9, EOMES, MPEG1, PDK4, CCLI10, K60 and FST), and tumor suppression (ADAMTS2, LXN, ARRDC3, WNT7A, CLDN1 and HPGD). …”
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134495por Srinagesh, Hrishikesh Krishna, Srinagesh, Hrishikesh Krishna, Kapoor, Urvi, Aziz, Mina, Ben-David, Kaitlyn, Major-Monfried, Hannah, Morales, George, Young, Rachel, Ozbek, Umut, Levine, John E, Ferrara, James LM“…Patients identified as high-risk will be candidates for more intensive immunosuppression or investigational therapies. …”
Publicado 2019
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134496por Biggs, Holly, Simoes, Eric A, Abu-Khader, Ilham Bulos, Thompson, Mark G, Gordon, Aubree, Hunt, Danielle R, DeGroote, Nicholas, Whitaker, Brett L, Wang, Lijuan, Marar, Basima, Gresh, Lionel, de Jesus, Joanne, Bino, Silva, Porter, Rachael M, McMorrow, Meredith, Campbell, William, Zhang, Yange, Lindstrom, Stephen, Thornburg, Natalie J, Langley, Gayle, Langley, Gayle, Peret, Teresa C T, Simaku, Artan, Gerber, Susan I“…Understanding global RSV epidemiology and risk factors for severe illness in low- and middle-income settings is critical as new vaccine candidates become available. METHODS: We prospectively enrolled infants aged < 1 year hospitalized with any acute illness from sites in Albania, Jordan, Nicaragua and Philippines during 2015–2017. …”
Publicado 2019
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134497por Alexander, Elizabeth, Schranz, Jennifer, Das, Anita F, Moran, Gregory J, Sandrock, Christian, File, Thomas M, Gelone, Steven P“…CONCLUSION: ECR and IACR rates with LEF were high and similar to MOX in patients who are candidates for outpatient (PORT III) and inpatient (PORT IV/V) treatment; LEF may be an alternative oral and IV monotherapy option for empiric CABP treatment in both populations. …”
Publicado 2019
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134498por Ren, Chenchen, Zhu, Yuanhang, Yang, Li, Zhang, Xiaoan, Liu, Ling, Wang, Zhaoxin, Jiang, Dongyuan“…CONCLUSIONS: High expression of HPV E6/E7 mRNA could be a good candidate as a diagnostic biomarker to triage ASCUS superseding HPV DNA. p16/Ki-67 immunocytochemistry is suggested to be a good tool to triage ASCUS, but it reduced the sensitivity of diagnosis when improves the diagnostic specificity.…”
Publicado 2019
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134499por Dubois-Camacho, Karen, Diaz-Jimenez, David, De la Fuente, Marjorie, Quera, Rodrigo, Simian, Daniela, Martínez, Maripaz, Landskron, Glauben, Olivares-Morales, Mauricio, Cidlowski, John A., Xu, Xiaojiang, Gao, Guangping, Xie, Jun, Chnaiderman, Jonás, Soto-Rifo, Ricardo, González, María-Julieta, Calixto, Andrea, Hermoso, Marcela A.“…MicroRNAs present a distorted feature in inflamed colonic mucosa and are potential IL-33 regulating candidates in UC. Therefore, we studied the microRNA and mRNA profiles in inflamed colonic samples of UC patients, evaluating the effect of a microRNA (selected by in silico analysis and its expression in UC patients), on IL-33 under inflammatory conditions. …”
Publicado 2019
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134500por Martínez-Romero, María Carmen, Ballesta-Martínez, María Juliana, López-González, Vanesa, Sánchez-Soler, María José, Serrano-Antón, Ana Teresa, Barreda-Sánchez, María, Rodriguez-Peña, Lidya, Martínez-Menchon, María Teresa, Frías-Iniesta, José, Sánchez-Pedreño, Paloma, Carbonell-Meseguer, Pablo, Glover-López, Guillermo, Guillén-Navarro, Encarna“…The WNT10A gene has been confirmed as the second molecular candidate that has been identified and accounts for one-half of non-EDA patients and one-third of NSTA patients. …”
Publicado 2019
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