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  1. 134501
    “…Of the miRNAs that were found to be differentially expressed across three age groups, we identified one candidate (miR-216a) implicated in beta cell proliferation for subsequent validation by RT-PCR. …”
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    miR-216a-targeting theranostic nanoparticles promote proliferation of insulin-secreting cells in type 1 diabetes animal model
  2. 134502
    por Janies, D., Pol, D.
    Publicado 2008
    “…Although SARS-CoV is widely believed to have originated in animals, there remains disagreement over the candidate animal source that lead to the original outbreak of SARS. …”
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    Large-Scale Phylogenetic Analysis of Emerging Infectious Diseases
  3. 134503
    “…The pangolin coronavirus model was used to identify drug candidates for treating 2019-nCoV infection. Two libraries of 2406 clinically approved drugs were screened for their ability to inhibit cytopathic effects on Vero E6 cells by GX_P2V infection. …”
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    Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model
  4. 134504
    por Kesel, Andreas J
    Publicado 2003
    “…Human immunodeficiency Retroviridae (HIVs) could possibly be influenced by B6RA and BNP. In addition, candidate targets of B6RA and BNP could be adsorption, transcription and/or viral RNA replication of an interestingly wide RNA virus selection including Picornaviridae (poliovirus, human coxsackievirus, hepatitis A virus), Flaviviridae (yellow fever virus, Dengue virus, West Nile virus, Kunjin virus, St. …”
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    A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B(6)-Derived zinc-Chelating trioxa-adamantane-triol
  5. 134505
    por Tezuka, Yuta, Turcu, Adina
    Publicado 2020
    “…Background: Medical treatment with mineralocorticoid receptor antagonists (MRAs) is preferred for patients with primary aldosteronism (PA) who are not surgical candidates. Adequate mineralocorticoid receptor blockade, as suggested by renin elevation above suppression levels, has been associated with lower rates of cardiovascular and renal complications as compared with PA with sustained renin suppression. …”
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    SAT-564 Effectiveness of Treatment with Mineralocorticoid Receptor Antagonistsin Primary Aldosteronism
  6. 134506
    “…Therefore, subjects with a normal DST and ACTH ≥20pg/ml should be candidates for relaxed surveillance.…”
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    OR25-06 Morning ACTH Levels as a Reliable Biomarker for Excluding Autonomous Cortisol Secretion in Incidetally Discovered Adrenal Adenomas. A Prospective Cohort
  7. 134507
    “…The patient started treatment with calcitriol and dibasic phosphorus one month ago because of bone and muscle pain, stiffness, functional limitation, periodontal disease, recent hip fracture and indication of left hip replacement. She is candidate for burosumab (Anti-FGF23 Monoclonal Antibody) treatment.CONCLUSIONS: We present the case of adult patient with X-linked hypophosphatemia. …”
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    MON-366 X Linked Hypophosphatemic Rachitism: Case Report in Adult Patient
  8. 134508
    “…The second is the emphasis on having a provider-patient discussion on alternative therapies when the patient may no longer be a candidate for denosumab while considering the patient’s risk for fracture. …”
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    SAT-365 Severe, Symptomatic Hypocalcemia Due to Denosumab and Vitamin D Deficiency in an Osteopenic Post-Menopausal Female
  9. 134509
    “…Aim: Recently three heterozygous MC3R variants identified from candidate gene sequencing of an obese human cohort were reported to be pathogenic. …”
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    SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants
  10. 134510
    “…Chi-square tests, one-way and mixed ANOVAs identified which baseline and longitudinal variables differed between and within trajectories. Candidate predictors that were statistically significant were then entered into a multinomial regression model to determine which factors independently predict trajectory membership. …”
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    O3.5. EARLY TRAJECTORIES OF POSITIVE SYMPTOMS REMISSION IN FIRST EPISODE-PSYCHOSIS: A 2-YEAR FOLLOW-UP STUDY
  11. 134511
    “…After having identified the most promising candidates from this analysis, we investigated their expression profile during postnatal maturation, in order to establish potential changes in their developmental trajectories. …”
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    S212. LONG-TERM CHANGES OF MIRNA30A FOLLOWING EXPOSURE TO PRENATAL STRESS: MODULATORY EFFECTS OF LURASIDONE TREATMENT DURING ADOLESCENCE
  12. 134512
    “…GTRs are identified as major candidates for Brassica crop improvement, thus dictating a need for their functional characterization. …”
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    A cell suspension based uptake method to study high affinity glucosinolate transporters
  13. 134513
    “…CONCLUSION: At 0.008 µM of TNF-α, an IR condition was induced in hTeno, supported with the significant reduction in glucose uptake, as well as significantly reduced total collagen, specifically COL-I expression levels, downregulation of candidate tenogenic markers genes (SCX and MKX), and upregulation of ECM catabolic genes (MMP-9 and MMP-13). …”
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    Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
  14. 134514
    “…On the basis of these results, one candidate was selected for further studies. In vivo studies using 10 nm PMAO-coated SPIONs were performed in ApoE(-/-) mice fed a western diet and instrumented with a perivascular cuff on the left carotid artery. …”
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    Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
  15. 134515
    “…Seventy-four patients were candidates for the response assessment. BCSC-expressing patients showed poor response compared to non-BCSC (16.1% responsive versus 51.2%, respectively), with a significance relation (P 0.003). …”
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    Clinical Impact of Breast Cancer Stem Cells in Metastatic Breast Cancer Patients
  16. 134516
    “…Gene expression was assessed by quantitative real-time PCR using a panel of 28 candidate genes with known roles in cartilage homeostasis, OA, extracellular-matrix degradation and obesity. …”
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    Gene expression in meniscus tears at the time of arthroscopic partial meniscectomy predicts osteoarthritis progression
  17. 134517
    “…ChAdOx2 RabG, a simian adenovirus-vectored rabies vaccine candidate, might have potential to provide low-cost single-dose pre-exposure rabies prophylaxis. …”
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    Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial
  18. 134518
    “…Thus, AAT is an appealing drug candidate to treat COVID-19 and should be studied.…”
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    Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19
  19. 134519
    “…RESULTS: A total of 937 immune- related lncRNAs were identified, 15 candidate immune-related lncRNAs were significantly associated with overall survival (OS). …”
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    Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature
  20. 134520
    “…The overall positive outcome of the method performance evaluation and the current lack of alternative standardised procedures, would indicate this method as being a promising candidate for a full validation study.…”
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    Particle size analysis of pristine food-grade titanium dioxide and E 171 in confectionery products: Interlaboratory testing of a single-particle inductively coupled plasma mass spectrometry screening method and confirmation with transmission electron microscopy
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