“…After the development and external validation of the Barcelona MRI risk calculator (BCN-RC 2) for the selection of candidates for prostate biopsy, we have now developed and externally validated BCN-RC 1 with the aim of reduce mpMRI demand. …”
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“…CK-based SBRT could be an alternative option for patients who are not candidate for BT. ABSTRACT: (1) Aim: To compare the treatment plans of stereotactic body radiotherapy (SBRT) with CyberKnife (CK) and high-dose-rate (HDR) intracavitary/interstitial brachytherapy (IC/ISBT) and examine the feasibility of CK-SBRT as a viable alternative to BT in patients with locally advanced cervical cancer (LACC). (2) Methods: A BT plan of 28 Gy in four fractions delivered previously to 20 patients with LACC was compared with a CK plan based on the same CT images with structures delineation for BT. …”
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“…In addition, we identified twelve unique selective regions for OSH containing candidate genes for a wide range of coat colors and patterns (ADAMTS20, KITLG, TYR, TYRO3—a MITF regulator, GPNMB, FGF7, RAB38) as well as congenital heart defects (PDE4D, PKP2) and gastrointestinal disorders (NLGN1, ALDH1B1). …”
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“…FB2001 is a drug candidate that targets the main protease of SARS-CoV-2 via covalently binding to cysteine 145. …”
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“…Adrenalectomy is the standard management for operative candidates. Preoperative alpha-adrenergic antagonism has been traditionally performed with the non-selective irreversible agent phenoxybenzamine. …”
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“…OBJECTIVE: To evaluate the rates and patterns of PPGL screening among candidate patients. METHODS: We conducted a retrospective review of adult patients (age ≥ 18 years) with hypertension seen in a university-based outpatient setting between 01/01/2017 - 06/30/2020, and we included patients with: 1) resistant hypertension (uncontrolled hypertension while taking at least 3 antihypertensive agents OR taking ≥4 antihypertensive agents); 2) hypertension at age <35 years; 3) adrenal nodule(s). …”
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“…Shared decision making between surgery, intervention radiology and the patient concluded that a less invasive procedure was preferred and the solitary node was a candidate for percutaneous ablation. Post ablation surveillance ultrasonography showed an 80% volume reduction (11×8×12 mm) in node size six weeks post intervention and a 95% volume reduction at six months (8×5×7 mm), with decreased cystic appearance and no vascularity. …”
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“…She was thought to be a poor candidate for thoracic surgery and was seen by radiation oncology who recommended stereotactic body radiation therapy (SBRT) to the right lung lesion with IR guided bland embolization of the liver lesions. …”
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“…Currently, ANT-1 and other potential candidate molecules are being evaluated in a battery of safety studies to select the optimal molecule(s) suitable for evaluation in human clinical trials. …”
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“…We propose a new scoring system (I-PET) combining WBS and FDG findings to identify patients more likely to be refractory to RAI, and who may be ideal candidates for 're-differentiation' before RAI treatment. …”
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“…This anisotropy makes the composite PLA/PCL scaffold an exciting candidate for applications in heart tissue engineering. …”
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“…Patients not deemed surgical candidates at the time of diagnosis and patients judged resectable with perioperative systemic treatment have similar survival outcomes.…”
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“…Folate receptor (FR) membrane protein is frequently overexpressed in 40% of human cancer and a good candidate for tumor-specific targeting. Specific active targeting of PS to FR can be achieved by conjugation with the folate moiety. …”
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“…Thus, using FK866 as a proof-of-concept candidate for drug repurposing, we introduced a novel, universally applicable preclinical drug development pipeline to circumvent subclonal aggressiveness, drug resistance, and stemness in lethal PCa.…”
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“…Use of end-of-treatment procalcitonin in VAP may serve as a candidate biomarker to predict VAP recurrence and death. …”
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“…Some patients underwent a genetic study with using genes panel of a panel of candidate genes responsible for the development of CH using the NGS method. …”
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“…Our aims were to investigate age-related differences in diagnostic accuracy and 2-week evolution of four leading candidate blood-based traumatic brain injury biomarkers—plasma glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, S100 calcium binding protein B and neuron-specific enolase—among participants in the 18-site prospective cohort study Transforming Research And Clinical Knowledge in Traumatic Brain Injury. …”
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“…The hub genes were selected from PPI Network, including ACACB, HMGCR, IDI1, HAO1, SHMT2, PSPH, PSAT1, ASS1, PHGDH, MTHFD2, and DPYD, and were further identified as candidate biomarkers to regulate the L-leu-induced proliferation of equine SCs. …”
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“…The presented in-silico/in-vitro research winnowed our own small libraries of antioxidant nitrogenous heterocyclic compounds, inspecting for the utmost convenient drug candidates expectedly capable of effectively working through this dual tactic. …”
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“…Within the coincident gene clusters, several genes that occurred on the GWAS outputs were associated with each other but dissociated with genes that did not appear in their respective GWAS output. To focus on candidate genes that could explain the difference in virulence between hosts, a comparative genomics analysis was performed on five P. ananatis strains that were differentially pathogenic on A. porrum or A. fistulosum × A. cepa. …”
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