“…RESULTS: A total of eight indicators were identified as risk factors for the development of CHD in middle-aged and elderly people by univariate analysis. Of these candidate predictors, four key parameters were defined to be significantly related to CHD by Lasso regression analysis, including age (OR 1.034, 95% CI 1.002 ~ 1.067, P = 0.040), hemoglobin A1c (OR 1.380, 95% CI 1.078 ~ 1.768, P = 0.011), ankle-brachial index (OR 0.078, 95% CI 0.012 ~ 0.522, P = 0.009), and brachial artery flow-mediated vasodilatation (OR 0.848, 95% CI 0.726 ~ 0.990, P = 0.037). …”
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“…RT-qPCR was used to detect differences in the relative mRNAs expression of candidate gene in mRNAs available with the proband and family members in the pedigree 2. …”
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“…Structural modeling and molecular docking were used to assess the interaction between candidate drugs and their targets. RESULTS: In the current study, we investigated the therapeutic potential of targeting TPX2, TTK, DDX39A, and LRP8, commonly upregulated genes in CRC identified through differential expression analysis in CRC and adjacent non-cancerous tissue. …”
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“…RELA was selected as a promising candidate biomarker affecting the prognosis of NSCLC patients. …”
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“…Conclusion: This study demonstrated the candidate HLA alleles that are significantly associated with several phenotypes of beta-lactam antibiotics-related SCARs. …”
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“…GOLM1, a type II Golgi transmembrane protein involved in the sorting and modification of proteins exported from the endoplasmic reticulum, emerged as a candidate that was increased 33% (p=0.014) in response to cytokines and coordinately upregulated with PD-L1. …”
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“…Clinical trials of cortisol-lowering drug candidates would benefit from user-friendly methods to measure cortisol in an outpatient setting. …”
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“…The findings suggest that ORG45335, which has been tested in humans for infertility, can potentially become a candidate drug for obesity. Presentation: Saturday, June 17, 2023…”
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“…These data suggest that ERβ agonism inhibits TGFβ-mediated liver fibrosis and supports further investigation of ERβ-targeted therapeutic candidates. Presentation: Saturday, June 17, 2023…”
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“…Furthermore, four patients have variants of interest in new candidate genes (MAU2, MAP3K4, NR2E1, C6ORF136). Conclusion: The diagnostic yield was similar to other studies in children with ISS, but a greater diversity of genetic causes was observed, with those involving growth-plate genes and the RAS-MAPK pathway being more frequent. …”
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“…Additionally, we used siRNA-mediated knockdown to validate candidate transcriptional regulators in human adipogenic progenitor cells. …”
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“…The culmination of these studies has led to a subset of candidate molecules that are being evaluated in safety studies to identify the compound(s) suitable for evaluation in human clinical trials. …”
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“…BACKGROUND: Comprehensive geriatric assessment (CGA) is difficult to perform in the emergency department (ED) environment and performance of screening tools in identifying vulnerable older ED patients who are best candidates for a geriatric consultation remain questionable. …”
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“…CONCLUSIONS: Providing an objective target that motivates and rewards recovery is a candidate change mechanism for complex interventions integrating biomarkers of disease. …”
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“…STUDY DESIGN, SIZE, DURATION: First, the prevalence and reproducibility of two candidate cut-off levels of subclinical hypothyroidism in a cohort of 177 infertile women was compared with 171 women not aiming for pregnancy. …”
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“…Previous reports indicated a higher rate of thromboembolic events (TEEs) in SCD patients. A number of candidate polymorphisms in certain genes (e.g., FVL, PRT, and MTHFR) were previously reported as risk factors for TEEs in different clinical conditions. …”
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“…The results showed that HH11 had more favorable adjustment in antioxidant and osmotic activity than IR29 upon exposure to salt stress, and highlighted candidate genes that could play roles in the function and regulation mechanism of salt tolerance in rice.…”
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“…INTRODUCTION: Patients with persistently active autoimmune diseases are considered to be candidates for autologous SCT. We performed a phase 1/2 study in a limited number of patients who were refractory to conventional immunosuppressive treatment. …”
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“…The recent identification of cell surface macromolecules on lymphocytes and macrophages, that may be distinct from immune response gene products but are likewise coded for by genes in the I region, has provided a group of suitable candidate molecules for such a role (2). In our initial studies on the biological and biochemical characteristics of AEF, we were impressed by the apparent preferential activity of the highly purified AEF preparations on B lymphocytes syngeneic to the activated T-cell population from which the AEF was obtained (1). …”
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“…These experiments have identified candidate genes and processes for further experimentation to increase our understanding of soybeans' response to iron deficiency stress.…”
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