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  1. 134701
    “…We explored the prevalence of virulence and antibiotic resistance genes in our cohort, and the conservation of genes encoding vaccine candidates. We also performed a timed phylogenetic investigation for a potential outbreak of a newly emerging nosocomial clone. …”
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    Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital
  2. 134702
    “…To facilitate clinical trials of disease-modifying therapies, plasma concentrations of Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. …”
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    Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)
  3. 134703
    “…An initial screen of candidate genes was developed to test which molecular pathways may be involved in generating adverse reproductive system effects. …”
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    Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide
  4. 134704
    “…Among the very poorly controlled children (n=30), we found 30% (9/30) were highly compliant toward their controller medication intake—suggesting a re-evaluation for change in medication or dosage—whereas 50% (15/30) were poorly compliant and candidates for a more timely intervention to improve compliance to mitigate their situation. …”
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    “How Is My Child’s Asthma?” Digital Phenotype and Actionable Insights for Pediatric Asthma
  5. 134705
    “…Taken together, our results show that Nestin is a useful marker for the identification of functional BMSCs and indicate that Nestin(+) BMSCs could be a better therapeutic candidate for cardiac repair. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13287-019-1217-x) contains supplementary material, which is available to authorized users.…”
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    Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction
  6. 134706
    “…Heterologous prime–boost regimens induce potent cellular immunity. MVA85A is a candidate TB vaccine. This phase I clinical trial was designed to evaluate whether alternating aerosol and intradermal vaccination routes would boost cellular immunity to the Mycobacterium tuberculosis antigen 85A (Ag85A). …”
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    Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial
  7. 134707
    por Almawi, Wassim, Dallel, Meriem
    Publicado 2019
    “…MicroRNAs (miRNAs) are small, non-coding RNA molecules which regulate gene expression at the post-transcriptional level, and seen as candidate biomarkers for several conditions, including PCOS. …”
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    MON-234 Targeted Profiling of Plasma MicroRNAs in Women with Polycystic Ovary Syndrome (PCOS): Impact of Obesity
  8. 134708
    “…Through our pilot evaluation, IL2RA mRNA expression appeared to be the best candidate as a prognostic biomarker. Therefore, the aim of this study is to characterize the prognostic value of IL2RA mRNA expression and evaluate its potential to refine prognostification in AML. …”
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    High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia
  9. 134709
    “…Despite the absence of complete GHD phenotype, data from the extended pedigree suggested GH1 as the initial candidate gene, identifying the same pathogenic GH1 variant in these four siblings. …”
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    SUN-245 Heterozygous GH1 p.R209H Variant within a Large Pedigree May Mimic a Growth Hormone Insensitivity Pattern
  10. 134710
    “…In this study, based on our previously constructed transcriptome of peanut leaves in response to drought stress, fourteen candidate genes involved in ABA production (including AhZEP, AhNCED1 and AhNCED3, AhABA2, AhAAO1 and AhAAO2, AhABA3, AhBG11 and AhBG24), catabolism (including AhCYP707A3, AhUGT71K1 and AhUGT73B4) and transport (including AhABCG22-1 and AhABCG22-2), were identified homologously and phylogenetically, and further analyzed at the transcriptional level by real-time RT-PCR, simultaneously determining ABA levels in peanut leaves in response to drought. …”
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    An abscisic acid (ABA) homeostasis regulated by its production, catabolism and transport in peanut leaves in response to drought stress
  11. 134711
    “…Our findings suggest petasin as a potential candidate for colon cancer therapy.…”
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    Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway
  12. 134712
    “…Meanwhile, the coupling of two antibodies did not influence the magnetic performance of USPIO, and the relatively small hydrodynamic size (59.60 ± 1.87 nm) of double antibody-conjugated USPIO probe makes it a viable candidate for use in MHCC MRI in vivo, as they are slowly phagocytosed by macrophages. …”
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    Development and in vitro study of a bi-specific magnetic resonance imaging molecular probe for hepatocellular carcinoma
  13. 134713
    “…Structure-based virtual screening against COX-2, mPGES-1 and CYP4A11was performed using the Surflex-Dock of the SYBYL suite. The candidates were further evaluated their antiangiogenic activities in a zebrafish embryo and rabbit corneal angiogenesis model. …”
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    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
  14. 134714
    por Motbainor, Achenef, Taye, Abeba
    Publicado 2019
    “…Binary logistic regression was run to identify candidate variable for multivariate logistic regression. …”
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    Wasting in under five children is significantly varied between rice producing and non-producing households of Libokemkem district, Amhara region, Ethiopia
  15. 134715
    por Laverty, Ursula, McHenry, Michelle
    Publicado 2019
    “…We held off on steroid treatment until he was investigated with CT PET and biopsy as his symptoms were longstanding. He was a high risk candidate for long term steroids given his recent MI and need for dual antiplatelet therapy. …”
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    40. A case of large vessel vasculitis presenting with limb claudication symptoms
  16. 134716
    “…DISCUSSION/SIGNIFICANCE OF IMPACT: The impact of the interviews and candid feedback provided by the scholars have been immensely valuable to program administrators to really understand the impact the program (and which components specifically) is having for the scholars. …”
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    3403 Understanding the career pathways of scholars participating in Scholar Programs and Academy
  17. 134717
    “…DISCUSSION/SIGNIFICANCE OF IMPACT: HCC is the second leading cause of cancer-related death worldwide and therapeutic options are limited for patients who are not surgical candidates. T-cells are a critical component of the anti-tumor response to HCC. …”
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    3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo
  18. 134718
    “…Minocycline is anti-inflammatory, protects against the toxic effects of β-amyloid in vitro and in animal models of AD, and is a credible repurposed treatment candidate. OBJECTIVE: To determine whether 24 months of minocycline treatment can modify cognitive and functional decline in patients with mild AD. …”
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    Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial
  19. 134719
    “…In this study, we screened DNA sequencing (DNA-seq) and transcriptome sequencing (RNA-seq) data for 650 individuals available through the Genotype-Tissue Expression (GTEx) project and identified 2 iciHHV-6A- and 4 iciHHV-6B-positive candidates. When corresponding tissue-specific gene expression signatures were analyzed, low levels HHV-6A/B gene expression was found across multiple tissues, with the highest levels of gene expression in the brain (specifically for HHV-6A), testis, esophagus, and adrenal gland. …”
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    Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response
  20. 134720
    “…High-thickness ZrB(2) 150 μm Integral Fuel Burnable Absorber (IFBA) is an excellent burnable poison (BP) candidate for long life soluble-boron-free core. However, in this study, we want to minimize the use of 150 μm IFBA since B-10 undergoes an (n, α) capture reaction, and the resulting helium raises the pressure within the plenum and in the cladding. …”
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    Neutronic investigation of alternative & composite burnable poisons for the soluble-boron-free and long life civil marine small modular reactor cores
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