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1por Feldmann, Anja, Arndt, Claudia, Koristka, Stefanie, Berndt, Nicole, Bergmann, Ralf, Bachmann, Michael P.“…Moreover, targeting of tumor-associated antigens (TAAs) that are not only expressed on tumor cells but also on vital tissues requires the possibility of a switch allowing to repeatedly turn the activity of CAR T cells on and off. Here we summarize the development of a modular CAR variant termed universal CAR (UniCAR) system that promises to overcome these limitations of conventional CARs.…”
Publicado 2019
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3por Pan, Kevin, Farrukh, Hizra, Chittepu, Veera Chandra Sekhar Reddy, Xu, Huihong, Pan, Chong-xian, Zhu, Zheng“…Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US Food and Drug Administration for hematological malignancies. …”
Publicado 2022
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8por Kulemzin, Sergey, Evsyukov, Igor, Belovezhets, Tatiana, Taranin, Alexander, Gorchakov, Andrey“…Compared to the pronounced efficacy of CAR T cell therapy in the treatment of B cell malignancies, rigorous clinical and preclinical assessment of the antitumor properties of CAR NK cells has been lagging behind. …”
Publicado 2021
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9“…T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. …”
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10por Poorebrahim, Mansour, Mohammadkhani, Niloufar, Mahmoudi, Reza, Gholizadeh, Monireh, Fakhr, Elham, Cid-Arregui, Angel“…In this context, methods based on the T cell receptor (TCR) engineering or chimeric antigen receptors (CARs) have shown great promise. This review focuses on the TCR-like CARs and TCR-CARs directed against tumor-derived epitopes, with a concerted view on neoepitopes. …”
Publicado 2021
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20por Xu, Dandan, Jin, Guoliang, Chai, Dafei, Zhou, Xiaowan, Gu, Weiyu, Chong, Yanyun, Song, Jingyuan, Zheng, Junnian“…Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the development of extracellular antigen recognition receptors, intracellular co-stimulatory molecules and the combination application of CARs and synthetic small molecules. …”
Publicado 2018
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