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  1. 2361
    “…In vitro, compared to MPP+ group, BBR significantly decreased the level of NLRP3 inflammasome including the expressions of NLRP3, PYD and CARD domain containing (PYCARD), cleaved caspase 1 (CASP1), and mature interleukin 1 beta (IL1B), via enhancing autophagic activity. …”
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    Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model
  2. 2362
    “…The Critical Appraisal Skills Programme (CASP) checklist was employed for study quality appraisal. …”
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    A meta-ethnographic study of fathers’ experiences of caring for a child with a life-limiting illness
  3. 2363
    “…The results of topological analysis revealed 20 core targets including caspase 3 (CASP3) and prostaglandin-endoperoxide synthase 2 (PTGS2) suggesting that the potential signaling pathway potentially involved in the treatment of LC included MAPK signaling pathway and P13K-AKT signaling pathway. …”
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    Chemical Characteristics of Platycodon grandiflorum and its Mechanism in Lung Cancer Treatment
  4. 2364
    “…Further meta-analysis with Japanese GWAS summary data from the CASP3 and FAM167A genomic regions validated these loci in Europeans showing consistent effects of the top SNVs in both populations. …”
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    Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease
  5. 2365
    “…Where costs were considered, a CASP economic evaluation checklist was used to assess data quality. …”
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    Scope and costs of autorefraction and photoscreening for childhood amblyopia—a systematic narrative review in relation to the EUSCREEN project data
  6. 2366
    “…STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. …”
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    The risk of pancreatic adenocarcinoma following SARS-CoV family infection
  7. 2367
    “…As a mechanism, western analyses show cleaved CASP3 and BID were increased whereas XIAP and cIAP2 were reduced due to COMT. …”
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    Suppressor effect of catechol-O-methyltransferase gene in prostate cancer
  8. 2368
    “…Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.…”
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    TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway
  9. 2369
    “…We assessed the methodological quality of included studies using the Critical Appraisal Skills Programme (CASP) checklist. We thematically analysed qualitative data from the included primary studies. …”
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    Parent–adolescent communication on adolescent sexual and reproductive health in sub-Saharan Africa: a qualitative review and thematic synthesis
  10. 2370
    “…In the protein–protein interaction network, CASP3 and TNF were date-hub proteins involved in several pathways. …”
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    Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information
  11. 2371
    “…The study was carried out based on the PRISMA guidelines, CASP and AACODS. The data resources included ISI/WOS, PubMed, Scopus, science direct, Ovid and ProQuest. …”
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    Different Approaches to Confronting the Biological Epidemic; Prevention Tools with an Emphasis on COVID-19: A Systematized Study
  12. 2372
    “…We systematically compared and assessed several tBID-based safety switch constructs with the clinically validated safety switches, including human herpes simplex virus thymidine kinase (HSV-TK) and inducible Caspase 9 (iCasp9). With optimization, we were able to achieve significant killing potency in vitro in Jurkat or human primary T cells. …”
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    In vitro assessment of an engineered tBID-based safety switch system in human T lymphocytes
  13. 2373
    “…Data were synthesised thematically following the Thomas and Harden approach. The CASP Qualitative Checklist was used to assess the quality of the included studies of this review. …”
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    Patient, carer, and staff perceptions of robotics in motor rehabilitation: a systematic review and qualitative meta-synthesis
  14. 2374
    “…Their quality of life (CASP-19) and their wealth were examined as the mediator and moderator of this relationship, respectively. …”
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    The dynamic relationship between hearing loss, quality of life, socioeconomic position and depression and the impact of hearing aids: answers from the English Longitudinal Study of Ageing (ELSA)
  15. 2375
    “…After the intersections the targets of this herb pair and CP, AD and MD – sorted by the value of degree – nine targets were identified as the vital ones: Akt1, IL6, TNF, PTGS2, JUN, CASP3, MAPK8, PPARγ and NOS3. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis results demonstrated 11 pathways, such as AGE-RAGE signalling pathway, IL-17 signalling pathway, TNF signalling pathway, which primarily participate in the pathological processes. …”
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    A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of chronic pain with comorbid anxiety and depression
  16. 2376
    “…Included articles were appraised using the CASP checklist. A meta-synthesis approach to analysis was used. …”
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    What are the strategies for implementing primary care models in maternity? A systematic review on midwifery units
  17. 2377
    “…RESULTS: The analysis identified 157 key targets and 9 core targets of JWYHT (including proto-oncogene (FOS), caspase 3 (CASP3), mitogen-activated protein kinase-3 (MAPK3), interleukin-6 (IL6), mitogen-activated protein kinase-1 (MAPK1), tumor necrosis factor (TNF), mitogen-activated protein kinase-8 (MAPK8), AKT serine/threonine kinase 1 (AKT1), and 5-hydroxytryptamine receptor 1B (5HT1B)) in SCDA. …”
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    A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies
  18. 2378
    “…Last, some of the PRGs (particularly CASP5) included in this PPS specifically support its feasibility for identifying EAC (area under the curves > 0.7). …”
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    Prognostic signature of esophageal adenocarcinoma based on pyroptosis-related genes
  19. 2379
    “…The PPI network included 525 targets, and the key targets were obtained by network topological parameters analysis, whereas the predicted key genes of GXZY on LC were AR, JUN, MYC, CASP3, MMP9, GAPDH, and RELA. Furthermore, these key genes were related to pathways in cancer, hepatitis B, TNF signaling pathway, and MAPK signaling pathway. …”
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    Uncovering the Pharmacological Mechanisms of Gexia-Zhuyu Formula (GXZY) in Treating Liver Cirrhosis by an Integrative Pharmacology Strategy
  20. 2380
    “…Result: A total of 86 overlapping targets of baicalin and CS were identified, among which MAPK14, IL2, FGF2, CASP3, PTGS2, PIK3CA, EGFR, and TNF were the core targets. …”
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    Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm
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