“…The quality of included studies was appraised using the Critical Appraisal Skills Program (CASP) qualitative research appraisal tool. Meta-synthesis was used to synthesize the data from included studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Discussion of the validity of all analyses was based on the CASP criteria. Study design, sample selection, and biases were scrutinized for each study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, a total of 15 genes were identified as hub genes. TNF, IL-1β, AKT1, CASP1, and STAT3 were highly expressed in lung tissues, thymus tissues, and lymphocytes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Eligibility also required records to include information about the context and the barriers and/or facilitators of the partners of the reported cross-sector partnerships. The CASP checklist and the ROBINS-I tool were used to appraise the included records and thematic analysis to summarise and synthesise the findings. …”
Enlace del recurso
Enlace del recurso

“…Network pharmacology analysis further revealed that these effects might be attributed to 14 active compounds (e.g., danshensu, salvianolic acid A, salvianolic acid B, rosmarinic acid, and tanshinone IIA) and 15 potential targets (e.g., CASP3, SOD1, NOS3, TNF, and TOP2A). The apoptosis pathway was highly enriched according to the KEGG analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Network pharmacology results showed that the interaction pathway between CaD and DKD was mainly enriched in MAPK and chemokine signaling pathways. AKT1, CASP3, IGF1, MAPK8, and CCL5 might be the key targets for CaD in treating DKD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Overall analysis of the PPI network showed a significant aggregation, with the top 10 hub co-expressed genes (CASP3, FYN, HNRNPA2B1, NR3C1, RELA, REL, POLR2F, RAN, RHOA, and STAT5B). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Knockdown of COX10-AS1 inhibited U87 cell growth, upregulated CASP1 and NLRP3, and released more IL1-β and IL-18 than the negative control. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Critical Appraisal Skills Programme (CASP) qualitative checklist was used to appraise studies’ methodological quality. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Quantitative data were appraised using the EPHPP tool, qualitative data using CASP’s Studies Checklist. Data were synthesized narratively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among the DEGs, a lot of redox metabolism- (e.g., ACOX3, SMOX, GPX3, GLO1, and P4HA1), ion transport- (e.g., MICU3, MCTP, PYX, STEAP3, and SLC30A2), drug metabolism- (e.g., HSP70, HSP90A, CYP2L1, and CYP9E2), immune response- (e.g., SMAD4, HDAC1, and DUOX), and apoptosis-related genes (e.g., CTSL, CASP7, and BIRC2) were identified, which suggests that Hg exposure may perturb the redox equilibrium, disrupt the ion homeostasis, weaken immune response and ability, and cause apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: A total of 91 active compounds were successfully identified in SNSF with the use of the comprehensive network pharmacology approach, and they were found to be closely connected to 112 depression-related targets, among which CREB1, NOS3, CASP3, TP53, ESR1, and SLC6A4 might be the main potential targets for the treatment of depression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The top 10 targets out of 41 ranked by MCC were IL-6, SRC, CTNNB1, STAT3, CASP3, TNF, EGFR, MAPK8, HSP90AA1, and PTGS2. ZQFZ granule treatment for NSCLC involved many pathways through KEGG analyses, which included pathways in cancer (hsa05200), proteoglycans in cancer (hsa05205), endocrine resistance (hsa01522), microRNAs in cancer (hsa05206), PI3K-Akt signaling pathway (hsa04151), and IL-17 signaling pathway (hsa04657). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Through random forest screening and Cox progression analysis, 10 prognostic methylation‐driver genes (AC008271.1, C11orf53, CASP8, F2RL2, GBP5, LUCAT1, RP11‐114B7.6, RP11‐149I23.3, RP11‐383 J24.1, and SLC35G2) were screened out. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All studies showed moderate to high study quality in the CASP assessment. About 6 to 38% of PwMS failed the on-road tests, showing difficulties in different areas of driving. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We constructed a HNSCC risk model with identified seven pyroptosis‐related genes (CASP1, GSDME, IL6, NLRP1, NLRP2, NLRP6, and NOD2) as prognostic signature genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Inflammation-related pathway enrichment and immune cell infiltration levels were altered between 2 clusters. Moreover, 6 genes (CASP8, GRK6, IL3RA, PLCB1, TBKBP1, and TNFSF10) were identified to generate a cGAS-STING pathway-related signature (CPRS). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A critical subnetwork was obtained with 13 core genes by analyzing the PPI network, which includes HMOX1, CXCL8, CCL2, IL6, MAPK8, CASP3, PTGS2, AKT1, IL1B, MYC, TP53, IFNG, and IL2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Key common targets included EGFR, MYC, AKT1, CASP3, CCND1, ERBB2, and common targets were enriched for the PI3K-AKT, JAK/STAT, MAPK, and C-type lectin receptor signaling pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A significant increase in the expression profile of the TP53 gene in the propofol group was registered (p = 0.029), while in the other study groups, no significant differences were reported. BCL2 and CASP3 expressions increased in the sevoflurane–lidocaine group without statistical significance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso