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  1. 3161
    “…Proteasome inhibitors, such as ixazomib, impact multiple aspects of HIV biology including latency, transcription initiation, viral replication, and infected cell killing through the HIV protease – Casp8p41 pathway, resulting in latency reversal and reduced measures of HIV reservoir size ex vivo. …”
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    Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.
  2. 3162
    “…We conducted a risk‐of‐bias assessment of the quantitative studies while we assessed the quality of mixed methods and qualitative studies through a 5‐item checklist adapted from the CASP Qualitative Checklist. We did not exclude studies due to quality issues. …”
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    Organized crime groups: A systematic review of individual‐level risk factors related to recruitment
  3. 3163
    “…In MDA-MB-468 cells, 16 apoptotic genes were upregulated, including TNFRSF10A, TNF, TNFRSF11B, FADD TNFRSF10B, CASP2, and TRAF2, all of which are important for the apoptotic pathway andsuppress the expression of one anti-apoptotic gene, BIRC5, in MDA-MB-231 cells. …”
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    Thymoquinone Alterations of the Apoptotic Gene Expressions and Cell Cycle Arrest in Genetically Distinct Triple-Negative Breast Cancer Cells
  4. 3164
    “…Using WGCNA, we also identified the fibroblast-related molecules, including ASPN, COL10A1, COL3A1, EDNRA, MYL9, PRELP, RAB31, SPARC, and THBS2, and immune-related molecules including CASP1, CCL5, CTSS, CYBRD1, PMP22, and TFEC. Based on these specific markers, we identified four distinct pathway-related subtypes, characterized by immune and fibrotic enriched (I/FE), immune enriched (IE), fibrotic enriched (FE), and immune and fibrotic desert (I/FD), of which I/FE was characteristic with the highest PC_Score and PI_Score whereas I/FD presents the opposite trend. …”
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    The Interplay of Four Main Pathways Recomposes Immune Landscape in Primary and Metastatic Gastroenteropancreatic Neuroendocrine Tumors
  5. 3165
    por Onyeneho, Karyn
    Publicado 2022
    “…H2: There is a relationship between HBA1C, TG, LDL, FG, FI and genetic associations among adults of African ancestry and the following: H2a: ACGT risk alleles H2b: Chromosomal regions 2, 7, 10, 11, 19 H2c: Sequence variant impacts: intergenic, intron, missense, and synonymous H2d: Minor allele frequencies < .05 H2e: Lead reference SNPs H2f: Variant coordinates H3: ALDH1A1, B3GALT2, C8orf37, CASP16, CCSAP, CDKN2B, CHRNA5, CRNN, CYP7B1, FAT4, FOXP1, GPC6, GRM4, LMCD1, MMP19, MYOM2, NOL11, PHF8, RP11-180C1.1, SLC45A1, SLC9A8, TLE1, ZPLD1 were predominant in adults of African ancestry with peripheral vascular disease in T2DM. …”
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    Genetic Determinants of Type 2 Diabetes Mellitus in Adults of African Ancestry: Identification of the Associated Factors
  6. 3166
    “…Moreover, five key active ingredients, namely quercetin, Stigmasterol, luteolin, kaempferol, and isorhamnetin, as well as five key targets including AKT1, TP53, TNF, VEGFA, and CASP3, were screened. In addition, five key signaling pathways, including cancer, Hepatitis B, Prostate cancer, Hepatitis C, and Pancreatic cancer pathways, were obtained through enrichment analysis. …”
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    Effects of botanical drugs in the treatment of cancer-related fatigue in patients with gastric cancer: A meta-analysis and prediction of potential pharmacological mechanisms
  7. 3167
    por Liu, Qin, Yu, Minghua, Zhang, Tao
    Publicado 2022
    “…We discovered 136 oxidative stress-related DEGs in UCEC, from which we screened 25 prognostic genes significantly related to the overall survival of UCEC patients. BCL2A1, CASP6, GPX2, HIC1, IL19, MSX1, RNF183, SFN, TRPM2 and HIST1H3C are associated with a good prognosis while CDKN2A, CHAC1, E2F1, GSDME, HMGA1, ITGA7, MCM4, MYBL2, PPIF, S100A1, S100A9, STK26 and TRIB3 are involved in a poor prognosis in UCEC. …”
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    Construction of Oxidative Stress-Related Genes Risk Model Predicts the Prognosis of Uterine Corpus Endometrial Cancer Patients
  8. 3168
    por Milia, Giulia, Noonan, Maria
    Publicado 2022
    “…Methodological quality was assessed using the qualitative Critical Appraisal Skills Programme (CASP) checklist. A thematic analysis framework guided the synthesis. …”
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    Experiences and perspectives of women who have committed neonaticide, infanticide and filicide: A systematic review and qualitative evidence synthesis
  9. 3169
    “…Inflammation-related genes (including CXCL8, MMP1, CASP3, FOS, CXCL2 and IL11) were screened as hub genes by calculating the topological characteristics of genes in the PPI network. …”
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    Inflammatory Genes Associated with Pristine Multi-Walled Carbon Nanotubes-Induced Toxicity in Ocular Cells
  10. 3170
    “…Abbreviations: AIF1/IBA1: allograft inflammatory factor 1; AMBRA1: autophagy/beclin 1 regulator 1; ATG4B: autophagy related 4B, cysteine peptidase; ATP: adenosine triphosphate; BECN1: beclin 1, autophagy related; CASP3: caspase 3; CBF: cerebral blood flow; CCA: common carotid artery; CCR2: chemokine (C-C motif) receptor 2; CIR: cranial irradiation; Csf1r/v-fms: colony stimulating factor 1 receptor; CX3CR1: chemokine (C-X3-C motif) receptor 1; DAPI: 4’,6-diamidino-2-phenylindole; DG: dentate gyrus; GO: Gene Ontology; HBSS: Hanks’ balanced salt solution; HI: hypoxia-ischemia; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MCA: medial cerebral artery; MTOR: mechanistic target of rapamycin kinase; OND: oxygen and nutrient deprivation; Ph/A coupling: phagocytosis-apoptosis coupling; Ph capacity: phagocytic capacity; Ph index: phagocytic index; SQSTM1: sequestosome 1; RNA-Seq: RNA sequencing; TEM: transmission electron microscopy; tMCAo: transient medial cerebral artery occlusion; ULK1: unc-51 like kinase 1.…”
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    Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
  11. 3171
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    Paper 11: Hip Cartilage Defects in Elite Athletes: Their Association with Specific Sports and ‘At-risk’ Motions
  12. 3172
    “…Genomic analysis identified opposite changes in ERβ target gene expression with only three common transcripts (HEY1, ICAM1, CASP1) in all three ECs; a unique profile was observed for each. …”
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    ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
  13. 3173
    “…RESULTS: The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR. …”
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    Comprehensive molecular biomarker identification in breast cancer brain metastases
  14. 3174
    “…Eighteen mutated genes were significantly different between the two cohorts, namely TP53, CDH1, NOTCH2, MYH9, BRCA2, ERBB4, POLE, FGFR3, ROS1, NOTCH4, LAMA2, EGFR, BRCA1, TP53BP1, ESR1, THBS1, CASP8, and NOTCH1. In IBC, the most frequently mutated genes were TP53 (43.0%), PIK3CA (29.5%), MYH9 (8.3%), NOTCH2 (8.3%), BRCA2 (7.7%), ERBB4 (7.1%), FGFR3 (6.4%), POLE (6.4%), LAMA2 (5.8%), ARID1A (5.1%), NOTCH4 (5.1%), and ROS1 (5.1%). …”
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    Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer
  15. 3175
    “…Abbreviations: ACTB, actin beta; ALKBH5, alkB homolog 5, RNA demethylase; ANXA5, annexin A5; ATG, autophagy-related; BafA, bafilomycin A(1); CASP3, caspase 3; ELAVL1, ELAV like RNA binding protein 1; FTO, FTO, alpha-ketoglutarate dependent dioxygenase; GFP, green fluorescent protein; GST, glutathione S-transferase; HNRNPD, heterogeneous nuclear ribonucleoprotein D; H/R, hypoxia/reoxygenation; I/R, ischemia/reperfusion; LAD, left anterior descending; m(6)A, N(6)-methyladenosine; MEFs, mouse embryo fibroblasts; Mer, mutated estrogen receptor domains; METTL3, methyltransferase like 3; METTL14, methyltransferase like 14; mRFP, monomeric red fluorescent protein; MTORC1, mechanistic target of rapamycin kinase complex 1; NMVCs, neonatal mouse ventricular cardiomyocytes; PCNA, proliferating cell nuclear antigen; PE, phosphatidylethanolamine; PI, propidium iodide; PTMs, post-translational modifications; PVDF, polyvinylidenedifluoride; RIP, RNA-immunoprecipitation; siRNA, small interfering RNA; SQSTM1, sequestosome 1; TFEB, transcription factor EB; TUBA: tublin alpha; WTAP, WT1 associated protein; YTHDF, YTH N6-methyladenosine RNA binding protein…”
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    METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
  16. 3176
    “…The Critical Appraisal Skills Programme (CASP) and Kirkpatrick’s model for the evaluation of training were used to ensure quality and rigor of the analysis. …”
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    A Web-Based Dementia Education Program and its Application to an Australian Web-Based Dementia Care Competency and Training Network: Integrative Systematic Review
  17. 3177
    por Resta, Elena, Mula, Silvana, Baldner, Conrad, Di Santo, Daniela, Agostini, Maximilian, Bélanger, Jocelyn J., Gützkow, Ben, Kreienkamp, Jannis, Abakoumkin, Georgios, Khaiyom, Jamilah Hanum Abdul, Ahmedi, Vjollca, Akkas, Handan, Almenara, Carlos A., Atta, Mohsin, Bagci, Sabahat Cigdem, Basel, Sima, Kida, Edona Berisha, Bernardo, Allan B. I., Buttrick, Nicholas R., Chobthamkit, Phatthanakit, Choi, Hoon‐Seok, Cristea, Mioara, Csaba, Sara, Damnjanović, Kaja, Danyliuk, Ivan, Dash, Arobindu, Douglas, Karen M., Enea, Violeta, Faller, Daiane Gracieli, Fitzsimons, Gavan J., Gheorghiu, Alexandra, Gómez, Ángel, Hamaidia, Ali, Han, Qing, Helmy, Mai, Hudiyana, Joevarian, Jeronimus, Bertus F., Jiang, Ding‐Yu, Jovanović, Veljko, Kamenov, Zeljka, Kende, Anna, Keng, Shian‐Ling, Kieu, Tra Thi Thanh, Koc, Yasin, Kovyazina, Kamila, Kozytska, Inna, Krause, Joshua, Kruglanski, Arie W., Kurapov, Anton, Kutlaca, Maja, Lantos, Nóra Anna, Lemay, Edward P., Lesmana, Cokorda Bagus J., Louis, Winnifred R., Lueders, Adrian, Malik, Najma Iqbal, Martinez, Anton P., McCabe, Kira O., Mehulić, Jasmina, Milla, Mirra Noor, Mohammed, Idris, Molinario, Erica, Moyano, Manuel, Muhammad, Hayat, Muluk, Hamdi, Myroniuk, Solomiia, Najafi, Reza, Nisa, Claudia F., Nyúl, Boglárka, O'Keefe, Paul A., Osuna, Jose Javier Olivas, Osin, Evgeny N., Park, Joonha, Pica, Gennaro, Pierro, Antonio, Rees, Jonas H., Reitsema, Anne Margit, Rullo, Marika, Ryan, Michelle K., Samekin, Adil, Santtila, Pekka, Sasin, Edyta, Schumpe, Birga M., Selim, Heyla A., Stanton, Michael Vicente, Stroebe, Wolfgang, Sultana, Samiah, Sutton, Robbie M., Tseliou, Eleftheria, Utsugi, Akira, van Breen, Jolien A., van Lissa, Caspar J., van Veen, Kees, van Dellen, Michelle R., Vázquez, Alexandra, Wollast, Robin, Yeung, Victoria Wai‐lan, Zand, Somayeh, Žeželj, Iris Lav, Zheng, Bang, Zick, Andreas, Zúñiga, Claudia, Leander, N. Pontus
    Publicado 2021
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    ‘We are all in the same boat’: How societal discontent affects intention to help during the COVID‐19 pandemic
  18. 3178
    “…Moreover, several hub-high traffic genes, including IL6, IL1B, IL10, TNF, SOCS1, SOCS3, ICAM1, PTEN, RHOA, GDI2, SUMO1, CASP1, IRAK3, HSPA5, ADRB2, PRF1, GZMB, OASL, CCL5, HSP90AA1, HSPD1, IFNG, MAPK1, RAB5A, and TNFRSF1A had the highest rates of information transfer in 9 candidate modules and central roles in COVID-19 immunopathogenesis. …”
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    Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic
  19. 3179
    “…ESBM1 decreased cortisol and caspase 3 (Casp-3) (P < 0.05). FM showed a higher content of tri-iodothyronine (T3) (P < 0.05) and a lower thyroxine/ tri-iodothyronine ratio compared with those in the other two groups (P < 0.05). …”
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    Comparative Efficacy of Fish Meal Replacement With Enzymatically Treated Soybean Meal on Growth Performance, Immunity, Oxidative Capacity and Fecal Microbiota in Weaned Pigs
  20. 3180
    “…Here, we investigated the relationship between from single nucleotide polymorphisms (SNPs) of the NLRP3, CARD8, AIM2, CASP-1, IFI16, and IL-1β inflammasome genes, as well as the profiles of secreted proinflammatory cytokines (e.g., IL-1β, IL-18, IL-33, and IL-6) with the TB clinical profiles, TB-HIV coinfection, and IRIS onset. …”
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    Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
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