“…First, we demonstrate that the PathwayKO platform can be utilized to comprehensively analyze real-world mouse KO transcriptomes (GSE22873 and GSE24327), which reveal systemic mechanisms underlying the innate immune responses triggered by non-infectious extensive hepatectomy (2 hours after 85% liver resection surgery) and infectious CASP-model sepsis (12 hours after CASP-model surgery). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…According to the component–target network and protein-protein interaction (PPI) network, stigmasterol, mairin, sitosterol, and dehydrocostus lactone were identified as the key components, and RAC-alpha serine/threonine-protein kinase (AKT1), prostaglandin-endoperoxide synthase 2 (PTGS2), interleukin 1 beta (IL1B), caspase-3 (CASP3), and CASP8 were selected as the core targets. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data support the hypothesis that LRRK2 acts as a proapoptotic kinase by regulating mitochondrial proteins (e.g., PRKN, PINK1, DRP1, and PUMA), transcription factors (e.g., c-JUN and TP53), and CASP3 in cells under stress conditions. Taken together, these observations suggest that LRRK2 is an important kinase in the pathogenesis of PD.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gene and/or protein expressions, by RT-qPCR and Western blotting, respectively, were assessed in terms of molecules related to oxidative stress (GST, GPx, GR and HO-1d), inflammation (NFκB, IL-1β and TNF-α) and apoptosis (BAX, Bcl-2, AIF, and CASP-1). In addition, MDA and MPO levels were measured by colorimetric assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Wild-type C57BL/6 female mice and Casp1(-/-) female mice (age, 7–9 weeks) were used. …”
Enlace del recurso
Enlace del recurso

“…These two predictors are similar to the original VSL1 predictor used in the CASP6 experiment. In both models, two specialized predictors were first built and optimized for short (≤30 residues) and long disordered regions (>30 residues), respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the spleen, 8/84 cancer-related genes were affected in FLT mice compared to AEM controls (P<0.05; up: Cdkn2a; down: Birc5, Casp8, Ctnnb1, Map2k1, Mdm2, NFkB1, Pdgfa). Pathway analysis (apoptosis signaling and checkpoint regulation) was used to map relationships among the cancer–related genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We evaluated several sequence based residue-residue contact predictors that participated in the tenth Critical Assessment of protein Structure Prediction (CASP) experiment. The evaluation was performed using standard assessment techniques such as those used by the official CASP assessors as well as two novel evaluation metrics (i.e., cluster accuracy and cluster count). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The use of apoptosis-resistant Casp8(Δhepa)-derived donor cells further enhanced the selection 3-fold after 12-weeks and up to 10-fold increase after 52 weeks compared with WT donors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, L-ARG protected against myocardial cellular death by reduction in NFκ-B mRNA as well as TNF-α level in association with decline in Casp-3 and FAS expressions andCasp-3protein content in addition to reduction of FAS positive cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There was increased MSC TGF-β1 production, and enhanced MSC deposition of extracellular collagen, with reduced synthesis of TNF-α, as well as a downregulation of the expression of pro-apoptotic CASP9, BAX, BID and BLK genes and upregulated expression of anti-apoptotic BCL-2 in hepatocytes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, TP53, CDK1, SMAD3, PIK3R1 and CASP3, with higher degrees, interacted with the cancer genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The in vitro study showed that EVO decreased the viability of A498 cells with the occurrence of apoptotic characteristics such as hypodiploid cells, DNA ladders, chromatin-condensed cells, and cleaved caspase (Casp)-3/poly(ADP ribose) polymerase (PARP) proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In peritoneal macrophages isolated from C57BL/6 mice, LPS/DSS challenge for 24 h increased the expression of the components of NLRP3 inflammasome NLRP3, Casp-1 p20/Casp-1 p45 ratio, proIL-1β and IL-1β and also enhanced autophagy (LC3-II/LC3-I ratio, Beclin-1 and SQSTM1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CpG-ODN combined with P. gingivalis LPS further reduced the percentage of AnnexinV(+)/7-AAD(-) cells within MZ B cells and IRA B cells in WT but not TLR2 KO or TLR4 KO mice. Pro-apoptotic CASP4, CASP9 and Dapk1 were significantly down-regulated in P. gingivalis LPS- and CpG-ODN-treated B cells from WT but not TLR2 KO or TLR4 KO mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Unlike caspase-3, the expression of inflammasome-related CASP1 (encodes caspase-1) and CASP4 (encodes caspase-4) is up-regulated in M1 but not in M2 cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast, gene expression of TNF and CASP3 was significantly upregulated. Elastic net regression analysis showed that fasting glucose levels and CASP3 predicted increased TNF expression in the post-obese group. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The different information sources are combined using deep neural networks. RESULTS: On 21 hard CASP11 FM targets, EPSILON-CP achieves a mean precision of 35.7% for top- L/10 predicted long-range contacts, which is 11% better than the CASP11 winning version of MetaPSICOV. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…S100A8 gene knockdown reduced cell proliferation in the HEC-1A cells compared with control cells, induced cell apoptosis, inhibited the phosphorylation of protein kinase B (Akt), and induced the expression of pro-apoptotic genes, including the cytochrome C gene, CYCS, BAD, BAX, FOXO1, FOXO3, CASP9, and CASP3. CONCLUSIONS: In endometrial carcinoma cells, down-regulation of the S100A8 gene induced cell apoptosis via inhibition of the phosphorylated or active form of protein kinase B (Akt).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We aimed to investigate whether variants of FasL, MSH2, ABCC5, CASP3 and CYP3A4 are associated with the outcome after chemotherapy-based treatment in osteosarcoma. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso